Sun, 06 Jul 2008 02:13:10 BST CiteULike: randyt's melatonin http://www.citeulike.org/user/randyt/tag/melatonin CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/randyt/article/2785316 <i>European Journal of Cancer Prevention, Vol. 16, No. 4. (August 2007), pp. 357-362.</i> Prevention of melatonin suppression by nocturnal lighting: relevance to cancer Leonida Kayumov Alan Lowe Shadab Rahman Robert Casper Colin Shapiro European Journal of Cancer Prevention, Vol. 16, No. 4. (August 2007), pp. 357-362. 2008-05-11T19:52:27-00:00 2007 European Journal of Cancer Prevention 16 4 357 362 melatonin http://www.citeulike.org/user/randyt/article/2784863 <i>Indian Journal of Medical Sciences, Vol. 60, No. 12. (2006), pp. 523-535.</i> Melatonin in pathogenesis and therapy of cancer T Ravindra NK Lakshmi YR Ahuja Indian Journal of Medical Sciences, Vol. 60, No. 12. (2006), pp. 523-535. 2008-05-11T19:13:59-00:00 2006 Indian Journal of Medical Sciences 60 12 523 535 melatonin http://www.citeulike.org/user/randyt/article/2784856 <i>Journal of the National Cancer Institute, Vol. 93, No. 20. (17 October 2001), pp. 1563-1568.</i> Rotating Night Shifts and Risk of Breast Cancer in Women Participating in the Nurses' Health Study Eva Schernhammer Francine Laden Frank Speizer Walter Willett David Hunter Ichiro Kawachi Graham Colditz Journal of the National Cancer Institute, Vol. 93, No. 20. (17 October 2001), pp. 1563-1568. 2008-05-11T19:07:57-00:00 2001 Journal of the National Cancer Institute 93 20 1563 1568 melatonin http://www.citeulike.org/user/randyt/article/2784850 <i>Journal of the National Cancer Institute, Vol. 95, No. 11. (4 June 2003), pp. 825-828.</i> Night-Shift Work and Risk of Colorectal Cancer in the Nurses’ Health Study Eva Schernhammer Francine Laden Frank Speizer Walter Willett David Hunter Ichiro Kawachi Charles Fuchs Graham Colditz Journal of the National Cancer Institute, Vol. 95, No. 11. (4 June 2003), pp. 825-828. 2008-05-11T19:03:58-00:00 2003 Journal of the National Cancer Institute 95 11 825 828 melatonin http://www.citeulike.org/user/randyt/article/2784841 <i>Cancer Epidemiology Biomarkers and Prevention, Vol. 13 (June 2004), pp. 936-943.</i> Epidemiology of Urinary Melatonin in Women and Its Relation to Other Hormones and Night Work Eva Schernhammer Bernard Rosner Walter Willett Francine Laden Graham Colditz Susan Hankinson Cancer Epidemiology Biomarkers and Prevention, Vol. 13 (June 2004), pp. 936-943. 2008-05-11T19:01:07-00:00 2004 Cancer Epidemiology Biomarkers and Prevention 13 936 943 melatonin http://www.citeulike.org/user/randyt/article/2784838 <i>Journal of the National Cancer Institute, Vol. 97, No. 14. (20 July 2005), pp. 1084-1087.</i> Urinary Melatonin Levels and Breast Cancer Risk Eva Schernhammer Susan Hankinson Journal of the National Cancer Institute, Vol. 97, No. 14. (20 July 2005), pp. 1084-1087. 2008-05-11T18:58:00-00:00 2005 Journal of the National Cancer Institute 97 14 1084 1087 melatonin http://www.citeulike.org/user/randyt/article/582451 <i>Cancer Causes and Control, Vol. 17, No. 4. (May 2006), pp. 539-545.</i> Circadian Disruption, Shift Work and the Risk of Cancer: A Summary of the Evidence and Studies in Seattle Scott Davis Dana Mirick doi:10.1007/s10552-005-9010-9 Cancer Causes and Control, Vol. 17, No. 4. (May 2006), pp. 539-545. 2006-04-12T04:08:22-00:00 2006 Cancer Causes and Control 0957-5243 17 4 539 545 Springer melatonin http://www.citeulike.org/user/randyt/article/2782249 <i>American Journal of Epidemiology, Vol. 164, No. 4. (15 August 2006), pp. 358-366.</i> Shift work, light at night, and breast cancer on Long Island, New York. ES O'Leary ER Schoenfeld RG Stevens GC Kabat K Henderson R Grimson MD Gammon MC Leske American Journal of Epidemiology, Vol. 164, No. 4. (15 August 2006), pp. 358-366. 2008-05-10T02:03:21-00:00 2006 American Journal of Epidemiology 164 4 358 366 melatonin http://www.citeulike.org/user/randyt/article/2782245 <i>Breast Cancer Research and Treatment, Vol. 108, No. 3. (20 April 2008), pp. 339-350.</i><br /><br />Abstract  Although many factors have been suggested as causes for breast cancer, the increased incidence of the disease seen in women working in night shifts led to the hypothesis that the suppression of melatonin by light or melatonin deficiency plays a major role in cancer development. Studies on the 7,12-dimethylbenz[a]anthracene and N-methyl-N-nitrosourea experimental models of human breast cancer indicate that melatonin is effective in reducing cancer development. In vitro studies in MCF-7 human breast cancer cell line have shown that melatonin exerts its anticarcinogenic actions through a variety of mechanisms, and that it is most effective in estrogen receptor (ER) α-positive breast cancer cells. Melatonin suppresses ER gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells. The anticarcinogenic action on MCF-7 cells has been demonstrated at the physiological concentrations of melatonin attained at night, suggesting thereby that melatonin acts like an endogenous antiestrogen. Melatonin also decreases the formation of estrogens from androgens via aromatase inhibition. Circulating melatonin levels are abnormally low in ER-positive breast cancer patients thereby supporting the melatonin hypothesis for breast cancer in shift working women. It has been postulated that enhanced endogenous melatonin secretion is responsible for the beneficial effects of meditation as a form of psychosocial intervention that helps breast cancer patients. Melatonin, environmental light, and breast cancer V Srinivasan D Spence S Pandi-Perumal I Trakht A Esquifino D Cardinali G Maestroni doi:10.1007/s10549-007-9617-5 Breast Cancer Research and Treatment, Vol. 108, No. 3. (20 April 2008), pp. 339-350. 2008-05-10T01:58:41-00:00 2008 Breast Cancer Research and Treatment 108 3 339 350 melatonin