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Abstract
Human adenoviruses (HAdV) can cause fatal complications such as disseminated disease especially in a post-transplant setting. With conventional methods, disseminated HAdV disease could only be diagnosed with delay. Quantification of the HAdV load by real-time PCR in peripheral blood promised to solve this diagnostic dilemma. Here we review the development, applications and significance of quantitative HAdV PCR. The high genetic divergence of the 56 HAdV ...
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posted to adenovirus nf-kb tlr4 trif
by saumen
on 2013-01-18 06:16:28
Note (first note only)
10.1126/science.1226625
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posted to adenovirus pkc rac
by saumen
on 2013-01-18 06:16:11
Note (first note only)
10.1128/JVI.02494-09
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Note (first note only)
10.1073/pnas.1009823107
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Note (first note only)
10.1038/nature09307
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Note (first note only)
10.1038/nature09307
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Note (first note only)
10.1038/nature09307
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posted to adenovirus apoptosis hnscc
by saumen
on 2013-01-18 06:15:33
Note (first note only)
10.1128/JVI.00343-09
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Note (first note only)
10.1128/JVI.02591-08
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posted to adenovirus pkc rac
by saumen
on 2013-01-18 06:10:01
Note (first note only)
10.1128/JVI.02494-09
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Note (first note only)
10.1073/pnas.1009823107
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Note (first note only)
10.1038/nature09307
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Note (first note only)
10.1038/nature09307
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Note (first note only)
10.1038/nature09307
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posted to adenovirus apoptosis hnscc
by saumen
on 2013-01-18 06:09:48
Note (first note only)
10.1128/JVI.00343-09
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Note (first note only)
10.1128/JVI.02591-08
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by Oliver Treacy, Aideen E. Ryan, Teresa Heinzl, et al.Lisa O'Flynn, Marese Cregg, Mieszko Wilk, Francesca Odoardi, Paul Lohan, Timothy O'Brien, Mikhail Nosov, Thomas Ritter
Abstract
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential which makes them attractive targets for regenerative medicine applications. However, to date, therapeutic success of MSC-therapy is limited and the genetic modification of MSCs using viral vectors is one option to improve their therapeutic potential. Ex-vivo genetic modification of MSCs using recombinant adenovirus (Ad) could be promising to reduce undesired immune responses as Ad ...
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Abstract
Tripartite motif-containing 21 (TRIM21) is a cytosolic IgG receptor that mediates intracellular virus neutralization by antibody. TRIM21 targets virions for destruction in the proteasome, but it is unclear how a substrate as large as a viral capsid is degraded. Here, we identify the ATPase p97/valosin-containing protein (VCP), an enzyme with segregase and unfoldase activity, as a key player in this process. Depletion or catalytic inhibition of VCP prevents capsid degradation and reduces neutralization. VCP is required concurrently with the proteasome, as ...
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In Pediatr Infect Dis J, Vol. 24 (2005), 733-4
Abstract
We describe the clinical characteristics of 209 children younger than 15 years of age with positive pharyngeal cultures for adenovirus. The mean age of the children was 37 +/- 33 months, and the mean peak temperature was 39.2 +/- 0.76 degrees C. On physical examination, tonsillitis was found for 88% of children; 52% of them had exudative tonsillitis. Forty-eight percent of the patients who had a white blood cell count performed had >15,000 leukocytes per mm, and 25% had >20,000 leukocytes ...
Note (first note only)
Dominguez, Olga
Rojo, Pablo
de Las Heras, Susana
Folgueira, Dolores
Contreras, Jesus Ruiz
Pediatr Infect Dis J. 2005 Aug;24(8):733-4.
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:02:34
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by Jeff Alexander, Simone Ward, Jason Mendy, et al.Darly J. Manayani, Peggy Farness, Jenny B. Avanzini, Ben Guenther, Fermin Garduno, Lily Jow, Victoria Snarsky, Glenn Ishioka, Xin Dong, Lo Vang, Mark J. Newman, Tim Mayall
posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:02:27
Abstract
Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine strain, to express the hemagglutinin (HA) gene from A/Vietnam/1194/2004 influenza virus (Ad4-H5-Vtn). Our hypothesis is that a mucosally-delivered replicating Ad4-H5-Vtn recombinant vector will be safe and induce protective immunity against H5N1 influenza virus infection and disease pathogenesis. ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:02:21
Abstract
Respiratory illnesses can cause substantial morbidity during military deployments. Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae, adenovirus, parainfluenza, and respiratory syncytial virus (RSV) are hypothesized causes. To determine pathogen-specific seroprevalence prior to and after deployment in support of Operation Enduring Freedom (OEF). A retrospective cohort study of 1000 service members deployed between June 30, 2004, and June 30, 2007, was conducted from 2008 through 2009. Pre- and post-deployment sera were tested for the presence of antibody to each pathogen. Pre-deployment IgG seropositivity ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:02:16
Abstract
Human adenovirus serotype 14 (HAdV-14; agent de Wit), a subspecies B2 member, was first identified in The Netherlands in 1955 in a military training camp and last reported in Eurasia in 1963. This virus has been conspicuous by its absence in global serosurveys and surveillance in subsequent decades. In early 2006, HAdV-14 was described at five military training centers in the United States and was subsequently associated with civilian cases of severe respiratory disease and fatalities in New York and California. ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:02:02
Abstract
Human adenovirus serotype 14 (HAdV-14; agent de Wit), a subspecies B2 member, was first identified in The Netherlands in 1955 in a military training camp and last reported in Eurasia in 1963. This virus has been conspicuous by its absence in global serosurveys and surveillance in subsequent decades. In early 2006, HAdV-14 was described at five military training centers in the United States and was subsequently associated with civilian cases of severe respiratory disease and fatalities in New York and California. ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:54
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:47
Abstract
Background. Adenovirus serotype 14 (Ad-14) recently emerged as a respiratory pathogen in the United States, with studies suggesting higher morbidity and mortality. This study was conducted to determine whether Ad-14 is associated with clinical outcomes in otherwise healthy patients with pneumonia. ...
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Journal of Infectious Diseases, Vol. 202, No. 1. (01 July 2010), pp. 93-103, doi:10.1086/653083
posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:35
Abstract
Background. First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered rare.With no precedent of circulation in North America, HAdV-14 has been isolated from military and civilian cases of ARD of variable severity since 2003 in the United States. ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:31
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:21
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:01:15
Abstract
Outbreak cases of acute respiratory disease (ARD) associated with subspecies B2 human adenovirus 11a (HAdV-11a) infection were detected during 2005 in a military basic training camp in Singapore. The Singapore HAdV-11a strain is highly similar to other Asian strains of HAdV-11, including strain QS-DLL, which is responsible for the recently described 2006 outbreak of ARD in China. ...
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by Zheng Wang, Anthony P. Malanoski, Baochuan Lin, et al.Nina C. Long, Tomasz A. Leski, Kate M. Blaney, Christian J. Hansen, Jason Brown, Michael Broderick, David A. Stenger, Clark Tibbetts, Kevin L. Russell, David Metzgar
Abstract
Military recruits experience a high incidence of febrile respiratory illness (FRI), leading to significant morbidity and lost training time. Adenoviruses, group A Streptococcus pyogenes , and influenza virus are implicated in over half of the FRI cases reported at recruit training center clinics, while the etiology of the remaining cases is unclear. In this study, we explore the carriage rates and disease associations of adenovirus, enterovirus, rhinovirus, Streptococcus pneumoniae , Haemophilus influenzae , and Neisseria meningitidis in military recruits using high-density ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:00:56
Abstract
Adenovirus plays a significant role in respiratory tract disease in pediatric and adult patients. It has been linked to outbreaks and epidemics in various patient populations, resulting in considerable morbidity and mortality. In this article, we discuss the epidemiology, pathogenesis, respiratory tract illnesses and complications, and roles of potential treatment options. The role of the past oral adenovirus vaccine and the military implications of its withdrawal from routine use in military recruits is discussed as well. ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:00:50
Abstract
Military personnel are highly susceptible to febrile respiratory illnesses (FRI), likely due to crowding, stress and other risk factors present in the military environment. Our objective was to investigate the viral etiological agents responsible for FRI among military recruits training in a tropical climate in Singapore. From March 2006 through April 2007, a total of 1354 oropharyngeal (throat) swabs were collected from military recruits who reported sick with an oral temperature of ≥38 °C and a cough and/or sore throat. Real-time polymerase ...
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posted to adenovirus military virology
by Zephyrus
on 2012-08-03 14:00:36
Abstract
Adenovirus 36 seropositivity is strongly associated with race and gender, but not obesity, among US military personnel
International Journal of Obesity advance online publication, November 10, 2009. doi:10.1038/ijo.2009.224
Authors: M P Broderick, C J Hansen, M Irvine, D Metzgar, K Campbell, C Baker
& K L Russell
...
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Blood, Vol. 95, No. 3. (Feb 2000), pp. 745-55
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Abstract
Adenovirus small e1a oncoprotein causes ~70% reduction in cellular levels of histone H3 lysine 18 acetylation (H3K18ac). It is unclear, however, where this dramatic reduction occurs genome-wide. ChIP-sequencing revealed that by 24 h after expression, e1a erases 95% of H3K18ac peaks in normal, contact-inhibited fibroblasts and replaces them with one-third as many at new genomic locations. The H3K18ac peaks at promoters and intergenic regions of ...
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posted to adenovirus
by koyanagicl
on 2012-03-28 16:02:52
Abstract
For more than half a century, researchers have studied the basic biology of Adenovirus (Ad), unraveling the subtle, yet profound, interactions between the virus and the host. These studies have uncovered previously unknown proteins and pathways crucial for normal cell function that the virus manipulates to achieve optimal virus replication and gene expression. In the infecting virion, the viral DNA is tightly condensed in a virally encoded protamine-like protein which must be remodeled within the first few hours of infection to ...
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Mol Cell Biol, Vol. 22, No. 8. (Apr 2002), pp. 2598-606
Abstract
The transcriptional coactivator p300 regulates transcription by binding to proteins involved in transcription and by acetylating histones and other proteins. These transcriptional effects are mainly at promoter and enhancer elements. Regulation of transcription also occurs through scaffold/matrix attachment regions (S/MARs), the chromatin regions that bind the nuclear matrix. Here we show that p300 binds to the S/MAR binding protein scaffold attachment factor A (SAF-A), a major constituent of the nuclear matrix. Using chromatin immunoprecipitations, we established that both p300 and SAF-A ...
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posted to adenovirus
by koyanagicl
on 2012-02-08 14:26:08
Abstract
As one of the first five human adenoviruses (HAdVs) to be sequenced, type 17 was important as a reference tool for comparative genomics of recently isolated HAdV pathogens in species D. HAdV-D17 was the first species D adenovirus to be sequenced and was deposited in GenBank in 1999. These genome data were not of high quality, and a redetermination of the same stock virus provides corrected data; among the differences are a length of 35,139 bp versus 35,100 bp in the ...
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Cancer research, Vol. 56, No. 24. (15 December 1996), pp. 5638-5646
Abstract
One potential avenue for future cancer therapy involves the specific targeting of effector genes to cancer cells throughout the body, including distant metastatic sites. As a first step toward this goal, we tested the ability of the transcriptional regulatory elements of the human and mouse tyrosinase genes to promote high levels of pigment cell-specific transcription. A construct consisting of 209 bp of the human tyrosinase ...
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Abstract
Oncolytic adenoviruses constitute a new and promising tool for cancer treatment that has been rapidly translated into clinical trials. However, minimal or absent expression of the adenovirus serotype 5 (Ad5) receptor CAR (coxsackievirus and adenovirus receptor) on cancer cells represents a major limitation for Ad5-based oncolysis. Here, we report on the resistance of CAR-negative primary melanoma cells to cell killing by wild-type Ad5 (Ad5wt) even ...
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Abstract
The expression of both proliferation-associated and cell type-specific genes is a hallmark of both cancer cells and tumor endothelial cells. The possibility to combine both features in a single transcriptional control unit would greatly increase the selectivity of vectors used for cancer gene therapy. Previous studies by our laboratory have shown that the transcription of several cell cycle genes is regulated by a novel cell ...
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Vol. 21, No. 46. (10 October 2002), pp. 7131-7136
Abstract
In order to investigate the molecular mechanisms implicated in the induction of chemo sensitivity by adenovirus E1a gene expression, we decided to investigate which signal transduction pathways could be affected by the E1a gene in Human Normal Fibroblast (IMR90). No effect was observed in SAPK pathways (p38MAPK and JNK), but E1a was able to affect the Akt activation mediated by insulin. This result was confirmed by transient transfection experiments performed in Cos-7 cells and also observed in other transformed cell lines ...
Note (first note only)
DA - 20021008
IS - 0950-9232 (Print)
IS - 0950-9232 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Antineoplastic Agents)
RN - 0 (Insulin)
RN - 0 (Proto-Oncogene Proteins)
RN - 15663-27-1 (Cisplatin)
RN - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN - EC 2.7.1.37 (AKT1 protein, human)
RN - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB - IM
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Vol. 5, No. 9. (September 1999), pp. 1076-1079
by R. Sanchez-Prieto, Alava E. De, T. Palomino, et al.J. Guinea, V. Fernandez, S. Cebrian, M. Lleonart, P. Cabello, P. Martin, Roman C. San, R. Bornstein, J. Pardo, A. Martinez, F. Diaz-Espada, Y. Barrios, S. Cajal
Abstract
Malignant transformation of human cells requires the accumulation of multiple genetic alterations, such as the activation of oncogenes and loss of function of tumor suppressor genes or those related to genomic instability. Among the genetic alterations most frequently found in human tumors are chromosomal translocations that may result in the expression of chimeric products with transforming capability or are able to change the expression of oncogenes. We show here that the adenovirus early region 1A (E1A) gene can induce a specific ...
Note (first note only)
DA - 19990924
IS - 1078-8956 (Print)
IS - 1078-8956 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (EWS-FLI fusion protein)
RN - 0 (Oncogene Proteins, Fusion)
RN - 0 (Proto-Oncogene Protein c-fli-1)
RN - 0 (RNA, Messenger)
RN - 0 (RNA-Binding Protein EWS)
RN - 0 (Transcription Factors)
SB - IM
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Vol. 5, No. 4. (July 1998), pp. 215-224
Abstract
The adenovirus E1a gene has been shown to be associated with high sensitivity to DNA-damaging agents and a decrease in the tumorigenicity of some human malignant cell lines. We have analyzed the tumorigenicity of the murine epidermoid carcinoma cell lines MSC11A5 and HaCa4, which have constitutive E1a expression, after the concomitant injection of retrovirus E1a producer cells with the carcinoma cells and even after the intratumoral injection of the E1a producer cells. The level of E1a expression was studied by Western ...
Note (first note only)
DA - 19981019
IS - 0929-1903 (Print)
IS - 0929-1903 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Antineoplastic Agents)
SB - IM
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Vol. 451 (1998), pp. 79-86
Note (first note only)
DA - 19990318
IS - 0065-2598 (Print)
IS - 0065-2598 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
SB - IM
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Vol. 13, No. 5. (5 September 1996), pp. 1083-1092
Abstract
Squamous cell carcinomas can show different oncogenic alterations, histological patterns, and an unpredictable clinical behavior. We previously reported that the adenovirus E1a gene may induce sensitivity to DNA-damaging agents in mouse keratinocytes. In order to study whether E1a expression could be used as a therapeutic agent in different malignant cell lines carrying mutations on the p53 gene and other oncogenic alterations, we transfected and infected several murine and human carcinoma cell lines (HaCa4; MSC11A5; HeLa) with vectors containing the 13S or ...
Note (first note only)
DA - 19961105
IS - 0950-9232 (Print)
IS - 0950-9232 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Antineoplastic Agents)
RN - 0 (Radiation-Sensitizing Agents)
RN - 0 (Tumor Suppressor Protein p53)
RN - 15663-27-1 (Cisplatin)
RN - 23214-92-8 (Doxorubicin)
SB - IM
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Vol. 11, No. 4. (17 August 1995), pp. 675-682
Abstract
p53 tumor suppressor protein is required for efficient execution of apoptosis after DNA-damage in many cell systems. Since the oncogene E1a confers susceptibility to DNA-damaging agents and stabilizes p53 protein, we investigate whether the sensitivity to anticancer drugs of E1a-expressing cells was mediated by binding to a specific set of cellular proteins (p60, p105, p107 and p300) and related to the induction of apoptosis and the level of p53 protein. We studied the effect of cisplatin (CDDP), doxorubicin (DOX) and ionizing ...
Note (first note only)
DA - 19950927
IS - 0950-9232 (Print)
IS - 0950-9232 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Tumor Suppressor Protein p53)
RN - 15663-27-1 (Cisplatin)
RN - 23214-92-8 (Doxorubicin)
SB - IM
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Vol. 10, No. 2. (February 2003), pp. 152-160
Abstract
Cancer gene therapy based on the use of suicide genes, such as the thymidine kinase gene, is not producing satisfactory results. Several approaches have been delineated to enhance the therapeutic responses, including augmentation of the bystander effect, the combination of the herpes simplex virus thymidine kinase-ganciclovir (HSVTK-GCV) system into replication competent adenoviruses and others. Moreover, because usually less than 20% of human malignant cells are in S-phase, the HSVTK-GCV system is not as efficient as expected. To increase the cytotoxic effects ...
Note (first note only)
DA - 20030121
IS - 0929-1903 (Print)
IS - 0929-1903 (Linking)
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Antibiotics, Antineoplastic)
RN - 0 (CCNB1 protein, human)
RN - 0 (Ccnb1 protein, mouse)
RN - 0 (Cyclin B)
RN - 0 (Cyclin B1)
RN - 15663-27-1 (Cisplatin)
RN - 82410-32-0 (Ganciclovir)
RN - EC 2.7.1.21 (Thymidine Kinase)
SB - IM
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Vol. 18, No. 6. (June 2001), pp. 1163-1167
Abstract
E1B-defective adenoviruses have been described as exerting selective cytopathic effects on transformed cells. Previously, we showed that adenovirus dl118, lacking both E1B proteins, very efficiently kills most human malignant cell lines. In order to study whether these selective effects were due to selective replication of dl118 in cells harboring specific genetic alterations, we compared the viability of various deficient mouse primary fibroblasts. We studied mouse embryonic fibroblasts (MEFs) derived from p16, p21, p27 and p53 knockout mice, as well as wild-type ...
Note (first note only)
DA - 20010514
IS - 1019-6439 (Print)
IS - 1019-6439 (Linking)
LA - eng
PT - Comparative Study
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
RN - 0 (Adenovirus E1A Proteins)
RN - 0 (Adenovirus E1B Proteins)
RN - 0 (CDKN1A protein, human)
RN - 0 (Cdkn1a protein, mouse)
RN - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN - 0 (Cyclins)
RN - 0 (Luminescent Proteins)
RN - 0 (Microfilament Proteins)
RN - 0 (Muscle Proteins)
RN - 0 (Tagln protein, mouse)
RN - 0 (Tumor Suppressor Protein p53)
RN -
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