Tag b2ar [68 articles] Export

Recent papers classified by the tag b2ar.

	Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations. [My Copy] Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 12. (24 March 2009), pp. 4689-4694. by Ron O. Dror, Daniel H. Arlow, David W. Borhani, Morten Ø. Jensen, Stefano Piana, David E. Shaw posted to theory structure modeling md flexibility dynamics b2ar activation by xdeupi on 2009-10-08 11:13:04 as along with 2 people dimka agrossfield
	Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. [My Copy] The EMBO journal, Vol. 28, No. 21. (4 November 2009), pp. 3315-3328. by Juan José J. Fung, Xavier Deupi, Leonardo Pardo, et al.Xiao Jie J. Yao, Gisselle A. Velez-Ruiz, Brian T. Devree, Roger K. Sunahara, Brian K. Kobilka posted to oligomerization inverse_agonist fret b2ar antagonist agonist by xdeupi on 2009-10-06 19:26:56 as
	Ligand entry and exit pathways in the beta2-adrenergic receptor. [My Copy] Journal of molecular biology, Vol. 392, No. 4. (2 October 2009), pp. 1102-1115. by Ting Wang, Yong Duan posted to pathway binding_kinetics binding b2ar by xdeupi on 2009-10-06 17:54:54 as
	Hot-Spots-Guided Receptor-Based Pharmacophores (HS-Pharm): A Knowledge-Based Approach to Identify Ligand-Anchoring Atoms in Protein Cavities and Prioritize Structure-Based Pharmacophores [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 7. (1 July 2008), pp. 1396-1410. by Caterina Barillari, Gilles Marcou, Didier Rognan posted to theory pharmacology ligands drug docking binding b2ar agonist by xdeupi on 2009-10-05 18:45:05 as along with 3 people tbinbal superpyrin higueruelo
	Coarse-grained modeling of allosteric regulation in protein receptors [My Copy] Proceedings of the National Academy of Sciences, Vol. 106, No. 34. (25 August 2009), pp. 14253-14258. by Ilya A. Balabin, Weitao Yang, David N. Beratan posted to rhodopsin gpcr coarse-grain b2ar by agrossfield on 2009-08-28 14:04:12 as along with 4 people and 1 group sobolevnrm pmung jmccammon okapi McCammon
	The role of membrane microdomains in shaping beta [sub 2]-adrenergic receptor-mediated cAMP dynamics [My Copy] Molecular BioSystems, Vol. 5, No. 8. (2009), pp. 832-837. by Lisa M. Dipilato, Jin Zhang posted to b2ar gpcr rafts by agrossfield on 2009-08-03 17:27:58 as
	Observation of Ionic Lock Formation in Molecular Dynamics Simulations of Wild Type 1 and 2 Adrenergic Receptors. [My Copy] Biochemistry (20 April 2009) by Stefano Vanni, Marilisa Neri, Ivano Tavernelli, Ursula Rothlisberger posted to b2ar gpcrs md by arnaucordomi on 2009-07-01 11:11:53 as along with 3 people and 1 group jmccammon agrossfield xdeupi McCammon
	Structure-based discovery of β2-adrenergic receptor ligands [My Copy] Proceedings of the National Academy of Sciences, Vol. 106, No. 16. (21 April 2009), pp. 6843-6848. by Peter Kolb, Daniel M. Rosenbaum, John J. Irwin, Juan J. Fung, Brian K. Kobilka, Brian K. Shoichet posted to b2ar gpcrs ligand-binding by arnaucordomi on 2009-06-30 15:31:40 as along with 2 people npt11tpn reyez
	A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein [My Copy] Proceedings of the National Academy of Sciences, Vol. 104, No. 18. (1 May 2007), pp. 7682-7687. by Matthew R. Whorton, Michael P. Bokoch, SÃ¸ren G. F. Rasmussen, et al.Bo Huang, Richard N. Zare, Brian Kobilka, Roger K. Sunahara posted to b2ar dimer by stacyfang on 2009-04-14 02:04:06 as along with 2 people and 1 group diod xdeupi LabCompMed
	Homodimerization of the beta2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting [My Copy] J. Biol. Chem., Vol. 279, No. 32. (6 August 2004), pp. 33390-33397. by Ali Salahpour, Stephane Angers, Jean-Francois Mercier, Monique Lagace, Stefano Marullo, Michel Bouvier posted to b2ar dimer by stacyfang on 2009-04-14 01:50:16 as
	Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site [My Copy] FEBS Letters, Vol. 582, No. 23-24. (15 October 2008), pp. 3335-3342. by S. Wolf, M. Bockmann, U. Howeler, J. Schlitter, K. Gerwert posted to b2ar molecular_dynamics by merj on 2009-04-03 12:45:06 as
	Agonizing over agonism: Should asthmatics turn their β-receptors on or off? [My Copy] Proceedings of the National Academy of Sciences, Vol. 106, No. 7. (17 February 2009), pp. 2095-2096. by Raymond B. Penn posted to b2ar by agrossfield on 2009-02-18 18:09:02 as
	Expression of beta(2)-adrenergic receptor in oral squamous cell carcinoma. [My Copy] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (26 December 2008) by Zheng Jun J. Shang, Ke Liu, De Feng F. Liang posted to b2ar cancer disease expression by xdeupi on 2009-01-19 13:57:04 as
	GPCR Engineering Yields High-Resolution Structural Insights into 2-Adrenergic Receptor Function [My Copy] Science, Vol. 318, No. 5854. (23 November 2007), pp. 1266-1273. by Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson, et al.Soren G. Rasmussen, Foon S. Thian, Tong S. Kobilka, Hee-Jung Choi, Xiao-Jie Yao, William I. Weis, Raymond C. Stevens, Brian K. Kobilka posted to activation b2ar crystallography xray by xdeupi on 2009-01-16 00:43:58 as along with 3 people jwm merj rph
	A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. [My Copy] Structure (London, England : 1993), Vol. 16, No. 6. (June 2008), pp. 897-905. by M. A. Hanson, V. Cherezov, M. T. Griffith, et al.C. B. Roth, V. P. Jaakola, E. Y. Chien, J. Velasquez, P. Kuhn, R. C. Stevens posted to b2ar cholesterol crystallography drug ligands structure by xdeupi to the group LabCompMed on 2009-01-09 12:05:17 as along with 1 person merj
	A Functional Polymorphism under Positive Evolutionary Selection in ADRB2 is Associated with Human Intelligence with Opposite Effects in the Young and the Elderly. [My Copy] Behavior genetics (15 October 2008) by Zoltán Bochdanovits, Florencia M. Gosso, Linda van den Berg, et al.Patrizia Rizzu, Tinca J. Polderman, Luba M. Pardo, Lorna M. Houlihan, Michelle Luciano, John M. Starr, Sarah E. Harris, Ian J. Deary, Eco J. de Geus, Dorret I. Boomsma, Peter Heutink, Danielle Posthuma posted to b2ar polymorphism by xdeupi on 2008-10-20 22:08:33 as
	Structure of a β1-adrenergic G-protein-coupled receptor [My Copy] Nature (25 June 2008) by Tony Warne, Maria J. Serrano-Vega, Jillian G. Baker, et al.Rouslan Moukhametzianov, Patricia C. Edwards, Richard Henderson, Andrew G. W. Leslie, Christopher G. Tate, Gebhard F. X. Schertler posted to b2ar binding docking drug ligands structure xray by xdeupi to the group LabCompMed on 2008-09-16 10:15:18 as along with 2 people and 1 group merj TonyIvetac McCammon
	A crystal clear view of the [beta]2-adrenergic receptor [My Copy] Nat Biotech, Vol. 26, No. 2. (February 2008), pp. 189-191. by Robert J. Lefkowitz, Jin-Peng Sun, Arun K. Shukla posted to b2ar structure by merj on 2008-06-02 15:14:08 as along with 2 people anna_yershova tkershaw
	Crystallizing thinking about the beta2-adrenergic receptor. [My Copy] Mol Pharmacol (31 January 2008) by Arun K K. Shukla, Jin-Peng P. Sun, Robert J J. Lefkowitz posted to b2ar crystallography gpcr review by xdeupi on 2008-05-13 16:09:07 as along with 3 people agrossfield tkershaw merj
	Clinical consequences of ADR2 polymorphisms [My Copy] Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358. by Hawkins, A. Gregory, Weiss, T. Scott, Bleecker, R. Eugene posted to b2ar disease drug genome pharmacology polymorphism review by xdeupi on 2008-05-03 17:12:39 as
	High-Resolution Crystal Structure of an Engineered Human 2-Adrenergic G Protein Coupled Receptor [My Copy] Science, Vol. 318, No. 5854. (23 November 2007), pp. 1258-1265. by Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson, et al.Soren G. F. Rasmussen, Foon S. Thian, Tong S. Kobilka, Hee-Jung Choi, Peter Kuhn, William I. Weis, Brian K. Kobilka, Raymond C. Stevens posted to b2ar gpcr membrane_proteins structure by merj on 2008-04-03 14:12:08 as along with 9 people and 3 groups anna_yershova artkoch cafeandaman jwm Fritz gcaltabiano sobolevnrm davidlott rph neurolit LabCompMed baker-group
	beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor. [My Copy] J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676. by M. T. Drake, J. D. Violin, E. J. Whalen, J. W. Wisler, S. K. Shenoy, R. J. Lefkowitz posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi to the group LabCompMed on 2008-02-27 10:39:07 as
	Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. [My Copy] Biochemistry, Vol. 29, No. 9. (6 March 1990), pp. 2335-2342. by H. G. Dohlman, M. G. Caron, A. DeBlasi, T. Frielle, R. J. Lefkowitz posted to b2ar dsb dtt lefkowitz by jddowney on 2007-09-26 19:06:21 as
	Ligand Stabilization of the B2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy [My Copy] Biochemistry, Vol. 35, No. 46. (19 November 1996), pp. 14445-14451. by S. Lin, U. Gether, B. K. Kobilka posted to b2ar cd dsb dtt kobilka by jddowney on 2007-09-26 19:01:10 as along with 1 person rph
	Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. [My Copy] J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691. by G. Swaminath, Y. Xiang, T. W. Lee, J. Steenhuis, C. Parnot, B. K. Kobilka posted to b2ar fluorescent kobilka labeling by jddowney on 2007-09-26 18:58:28 as along with 1 person and 1 group xdeupi LabCompMed
	A fluorescent probe designed for studying protein conformational change. [My Copy] Proc Natl Acad Sci U S A, Vol. 102, No. 4. (25 January 2005), pp. 965-970. by B. E. Cohen, A. Pralle, X. Yao, et al.G. Swaminath, C. S. Gandhi, Y. N. Jan, B. K. Kobilka, E. Y. Isacoff, L. Y. Jan posted to apm b2ar fcs membrane-protein by yanjiang on 2007-07-05 20:20:50 as along with 2 people and 2 groups xdeupi samjlord LabCompMed moernerlab
	Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein. [My Copy] Proc Natl Acad Sci U S A, Vol. 98, No. 15. (17 July 2001), pp. 8469-8474. by G. Peleg, P. Ghanouni, B. K. Kobilka, R. N. Zare posted to b2ar fcs membrane-protein by yanjiang on 2007-07-05 20:17:19 as along with 2 people and 2 groups quanwang xdeupi LabCompMed moernerlab
	G-protein-coupled receptor signalling through protein networks. [My Copy] Biochem Soc Trans, Vol. 35, No. Pt 1. (February 2007), pp. 23-27. by A. D. Strosberg, C. Nahmias posted to b2ar gpcr pharmacology review structure by xdeupi on 2007-06-29 21:10:57 as along with 1 group LabCompMed
	G protein coupled receptor structure and activation. [My Copy] Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 794-807. by B. K. Kobilka posted to switch review gpcr b2ar activation by xdeupi to the group LabCompMed on 2007-06-02 19:19:32 as along with 4 people and 1 group guhjy Fritz merj adamsdi neurolit
	Role of group-conserved residues in the helical core of beta2-adrenergic receptor. [My Copy] Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 7027-7032. by P. Chelikani, V. Hornak, M. Eilers, et al.P. J. Reeves, S. O. Smith, U. L. Rajbhandary, H. G. Khorana posted to tm4 switch ser b2ar agonist activation by xdeupi to the group LabCompMed on 2007-04-26 12:27:17 as
	Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism. [My Copy] J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49. by L. Elster, C. Elling, A. Heding posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as along with 1 group LabCompMed
	Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. [My Copy] The EMBO journal, Vol. 26, No. 1. (10 January 2007), pp. 53-64. by Yutong Sun, Jianyun Huang, Yang Xiang, et al.Murat Bastepe, Harald Jüppner, Brian K. Kobilka, Jillian J. Zhang, Xin-Yun Y. Huang posted to activation b2ar drug pharmacology switch by Guff32 on 2007-03-21 12:02:13 as along with 2 people and 1 group diod xdeupi LabCompMed
	Structure and conformational changes in the C-terminal domain of the beta 2-adrenoceptor: Insights from fluorescence resonance energy tranfer studies. [My Copy] J Biol Chem (8 March 2007) by Sebastien Granier, Samuel Kim, Aaron M M. Shafer, et al.Venkata R P R. Ratnala, Juan J J. Fung, Richard N N. Zare, Brian K K. Kobilka posted to activation b2ar cterm dynamics fret structure by xdeupi on 2007-03-21 11:39:56 as along with 1 group LabCompMed
	Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. [My Copy] J Clin Invest, Vol. 117, No. 1. (January 2007), pp. 229-235. by F. Rochais, J. P. Vilardaga, V. O. Nikolaev, M. Bünemann, M. J. Lohse, S. Engelhardt posted to activation agonist b2ar helix8 mutation by xdeupi on 2007-03-12 14:39:00 as along with 1 group LabCompMed
	Subclassification and nomenclature of alpha- and beta-adrenoceptors. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134. by J. P. Hieble posted to agonist b2ar drug genome ligands pharmacology review by xdeupi to the group LabCompMed on 2007-03-12 14:33:19 as
	Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists. [My Copy] Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216. by J. P. Hieble posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as along with 1 group LabCompMed
	Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. [My Copy] J Cell Biol, Vol. 176, No. 4. (12 February 2007), pp. 521-533. by O. G. Shcherbakova, C. M. Hurt, Y. Xiang, et al.M. L. Dell'acqua, Q. Zhang, R. W. Tsien, B. K. Kobilka posted to b2ar imaging by xdeupi to the group LabCompMed on 2007-02-20 10:06:46 as
	Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling. [My Copy] PLoS Comput Biol, Vol. 3, No. 1. (12 January 2007) by Tamara L L. Kinzer-Ursem, Jennifer J J. Linderman posted to activation agonist b2ar pharmacology by xdeupi to the group LabCompMed on 2007-02-13 15:38:17 as
	The Cationminus signpi Interaction. [My Copy] Chem Rev, Vol. 97, No. 5. (5 August 1997), pp. 1303-1324. by Jennifer C. Ma, Dennis A. Dougherty posted to trp ligands histamine cation-pi binding b2ar by xdeupi on 2007-01-11 14:28:54 as along with 1 group LabCompMed
	Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor. [My Copy] J Comput Aided Mol Des (13 October 2006) by Stanley R. Krystek, S R. Kimura, Andrew J. Tebben posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as along with 1 person and 1 group daevans LabCompMed
	GRK specificity for beta -arrestin recruitment to the beta 2-adrenergic receptor revealed by fluorescence resonance energy transfer. [My Copy] J Biol Chem (10 May 2006) by Jonathan D D. Violin, Xiu-Rong R. Ren, Robert J J. Lefkowitz posted to arrestin b2ar fret gpcr by xdeupi to the group LabCompMed on 2006-09-23 11:20:25 as along with 1 person tkershaw
	Functional selectivity and classical concepts of quantitative pharmacology. [My Copy] J Pharmacol Exp Ther (27 June 2006) by Jonathan D D. Urban, William P P. Clarke, Mark von Zastrow, et al.David E E. Nichols, Brian K K. Kobilka, Harel Weinstein, Jonathan A A. Javitch, Bryan L L. Roth, Arthur Christopoulos, Patrick Sexton, Keith Miller, Michael Spedding, Richard B B. Mailman posted to activation b2ar pharmacology review switch by xdeupi on 2006-09-07 15:43:50 as along with 2 people and 1 group shoshin kentsis LabCompMed
	Coupling ligand structure to specific conformational switches in the [beta]2-adrenoceptor [My Copy] Nat Chem Biol, Vol. 2, No. 8. (2006), pp. 417-422. by Xiaojie Yao, Charles Parnot, Xavier Deupi, et al.Venkata R. Ratnala, Gayathri Swaminath, David Farrens, Brian Kobilka posted to activation b2ar bimane lock by xdeupi to the group LabCompMed on 2006-09-07 14:39:58 as along with 1 person lechristophe
	A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. [My Copy] Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293. by S. B. Liggett, J. Mialet-Perez, S. Thaneemit-Chen, et al.S. A. Weber, S. M. Greene, D. Hodne, B. Nelson, J. Morrison, M. J. Domanski, L. E. Wagoner, W. T. Abraham, J. L. Anderson, J. F. Carlquist, H. J. Krause-Steinrauf, L. C. Lazzeroni, J. D. Port, P. W. Lavori, M. R. Bristow posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as along with 1 group LabCompMed
	Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. [My Copy] J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125. by B. Behr, C. Hoffmann, G. Ottolina, K. N. Klotz posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi to the group LabCompMed on 2006-09-05 11:05:20 as
	The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled receptors. [My Copy] Ann N Y Acad Sci, Vol. 1070 (July 2006), pp. 105-119. by M. H. Perrin, C. R. Grace, R. Riek, W. W. Vale posted to b2ar nterm structure by xdeupi on 2006-09-05 10:22:30 as along with 1 group LabCompMed
	Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation. [My Copy] J Biol Chem, Vol. 281, No. 25. (23 June 2006), pp. 17337-17346. by C. E. Elling, T. M. Frimurer, L. O. Gerlach, R. Jorgensen, B. Holst, T. W. Schwartz posted to activation b2ar modeling pro-kink structure switch toggle transmembrane by xdeupi on 2006-07-04 12:17:13 as along with 1 person and 1 group IrinaMoreira LabCompMed
	Changes in interhelical hydrogen bonding upon rhodopsin activation. [My Copy] J Mol Biol, Vol. 347, No. 4. (8 April 2005), pp. 803-812. by A. B. Patel, E. Crocker, P. J. Reeves, et al.E. V. Getmanova, M. Eilers, H. G. Khorana, S. O. Smith posted to activation b2ar binding hbond helix ligands nmr pro-kink rhodopsin ser structure switch tm5 tm6 toggle by xdeupi on 2006-06-01 13:51:11 as along with 1 group LabCompMed
	Toward the active conformations of rhodopsin and the beta2-adrenergic receptor. [My Copy] Proteins, Vol. 56, No. 1. (1 July 2004), pp. 67-84. by P. R. Gouldson, N. J. Kidley, R. P. Bywater, et al.G. Psaroudakis, H. D. Brooks, C. Diaz, D. Shire, C. A. Reynolds posted to activation b2ar modeling rhodopsin structure by xdeupi on 2006-03-08 14:57:08 as along with 1 group LabCompMed
	Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines. [My Copy] J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719. by H. Xhaard, V. V. Rantanen, T. Nyrönen, M. S. Johnson posted to agonist b2ar binding gpcr ligands modeling by xdeupi to the group LabCompMed on 2006-03-06 10:11:30 as

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activation	68
agonist	46
ligands	27
structure	22
drug	21
pharmacology	21
binding	20
switch	20
gpcr	18
modeling	11
review	10
ser	10
tm6	9
pro-kink	8
toggle	8
fret	7
arrestin	6
disease	6
imaging	6
polymorphism	6
tm5	6
genome	5
lock	5
rhodopsin	5
crystallography	4
dimer	4
dynamics	4
fluorescence	4
gproteins	4
helix	4
helix8	4
mutation	4
docking	3
fcs	3
ionic	3
md	3
membrane-protein	3
tm3	3
xray	3
biased_agonism	2
bimane	2
cation-pi	2
cholesterol	2
cterm	2
dsb	2
dtt	2
flexibility	2
gpcrs	2
hbond	2
histamine	2
internalization	2
kobilka	2
membrane_proteins	2
nmr	2
nterm	2
s542	2
theory	2
tm4	2
transmembrane	2
trp	2
w648	2
antagonist	1
apm	1
binding_kinetics	1
cancer	1
cd	1
coarse-grain	1
dry	1
expression	1
fluorescent	1
inverse_agonist	1
labeling	1
lefkowitz	1
ligand-binding	1
lmc_101	1
molecular_dynamics	1
oligomerization	1
pathway	1
protonation	1
rafts	1
solvation	1
water	1

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