Tag chk1 [83 articles] Export

Recent papers classified by the tag chk1.

	Implications for Chk1 Regulation: The 1.7 p Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1 [My Copy] Cell, Vol. 100, No. 6. (March 2000), pp. 681-692. by P CHEN, posted to kinase domain crystal_structure chk1 1ia8 by GermanErlenkamp on 2009-12-15 09:41:41 as
	Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control. [My Copy] The Journal of biological chemistry, Vol. 284, No. 7. (13 February 2009), pp. 4132-4139. by A. R. Demidova, M. Y. Aau, L. Zhuang, Q. Yu posted to atr camptothecin chk1 damage dna by diaz0058 on 2009-07-24 00:53:55 as
	Human Chk1 Expression Is Dispensable for Somatic Cell Death and Critical for Sustaining G2 DNA Damage Checkpoint [My Copy] Molecular Cancer Therapeutics, Vol. 2, No. 6. (June 2003), pp. 543-548. by Zehan Chen, Zhan Xiao, Jun Chen, et al.Shi-Chung Ng, Thomas Sowin, Hing Sham, Saul Rosenberg, Steve Fesik, Haiying Zhang posted to chk1 dde by aheilbut on 2009-06-23 23:38:18 as
	Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents [My Copy] J. Biol. Chem., Vol. 278, No. 24. (6 June 2003), pp. 21767-21773. by Zhan Xiao, Zehan Chen, Angelo H. Gunasekera, et al.Thomas J. Sowin, Saul H. Rosenberg, Steve Fesik, Haiying Zhang posted to chk1 dde dnadamage by aheilbut on 2009-06-23 23:32:05 as along with 1 person DNAReplication
	Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation [My Copy] Oncogene, Vol. aop, No. current. by K. R. Greenow, A. R. Clarke, R. H. Jones posted to chk1 death intestine liver p53 by catcremona on 2009-03-19 12:13:22 as
	Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. [My Copy] Mol Biol Cell, Vol. 12, No. 3. (March 2001), pp. 551-563. by J. Lee, A. Kumagai, W. G. Dunphy posted to cdk1 checkpoint chk1 replication wee1 by catcremona on 2009-02-24 20:35:33 as along with 1 person DNAReplication
	Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. [My Copy] Mol Cell, Vol. 11, No. 2. (February 2003), pp. 329-340. by J. Lee, A. Kumagai, W. G. Dunphy posted to atr checkpoint chk1 claspin dna rad17 replication rpa by catcremona on 2009-02-24 20:08:43 as along with 1 person DNAReplication
	Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. [My Copy] Mol Biol Cell, Vol. 16, No. 11. (November 2005), pp. 5269-5282. by J. Lee, D. A. Gold, A. Shevchenko, A. Shevchenko, W. G. Dunphy posted to checkpoint chk1 claspin fork replication by catcremona on 2009-02-24 20:06:42 as along with 1 person DNAReplication
	Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. [My Copy] Current biology : CB, Vol. 10, No. 24. (8 2000), pp. 1565-1573. by M. Hekmat-Nejad, Z. You, M. C. Yee, J. W. Newport, K. A. Cimprich posted to atr checkpoint chk1 dna replication xenopus by catcremona on 2009-02-11 23:05:14 as
	Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts [My Copy] Genes Dev., Vol. 14, No. 21. (1 November 2000), pp. 2745-2756. by Zijian Guo, Akiko Kumagai, Sophie X. Wang, William G. Dunphy posted to atr chk1 dna replication xenopus by catcremona on 2009-02-11 22:50:24 as along with 1 person DNAReplication
	PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. [My Copy] Genes Dev (3 May 2005) by Xiongbin Lu, Bonnie Nannenga, Lawrence A A. Donehower posted to checkpoints chk1 p53 ppm1d by catcremona on 2009-02-06 02:07:18 as along with 2 people sansam DNAReplication
	Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. [My Copy] The Journal of biological chemistry, Vol. 278, No. 45. (7 November 2003), pp. 45027-45033. by R. Agarwal, Z. Tang, H. Yu, O. Cohen-Fix posted to chk1 damage degradation dna securin by catcremona on 2009-02-06 02:04:05 as
	Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. [My Copy] Genes Dev, Vol. 14, No. 12. (15 June 2000), pp. 1439-1447. by H. Takai, K. Tominaga, N. Motoyama, et al.Y. A. Minamishima, H. Nagahama, T. Tsukiyama, K. Ikeda, K. Nakayama, M. Nakanishi, K. Nakayama posted to chk1 knockout mouse by catcremona on 2009-02-06 01:50:27 as along with 1 person DNAReplication
	An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. [My Copy] Cancer research, Vol. 60, No. 3. (1 February 2000), pp. 566-572. by J. R. Jackson, A. Gilmartin, C. Imburgia, J. D. Winkler, L. A. Marshall, A. Roshak posted to arrest chk1 damage dna by catcremona on 2009-02-06 01:47:51 as
	ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. [My Copy] Mol Cell Biol, Vol. 21, No. 13. (July 2001), pp. 4129-4139. by H. Zhao, H. Piwnica-Worms posted to atr checkpoint chk1 damage dna by catcremona on 2009-02-06 01:46:48 as along with 2 people ecattell DNAReplication
	Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. [My Copy] Genes Dev, Vol. 14, No. 12. (15 June 2000), pp. 1448-1459. by Q. Liu, S. Guntuku, X. S. Cui, et al.S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. DeMayo, A. Bradley, L. A. Donehower, S. J. Elledge posted to atr chk1 damage dna g2m by catcremona on 2009-02-06 01:45:16 as along with 1 person DNAReplication
	Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. [My Copy] Mol Cell, Vol. 6, No. 4. (October 2000), pp. 839-849. by A. Kumagai, W. G. Dunphy posted to chk1 claspin damage dna by catcremona on 2009-02-06 01:43:43 as along with 1 person DNAReplication
	BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. [My Copy] Nat Genet, Vol. 30, No. 3. (March 2002), pp. 285-289. by R. I. Yarden, S. Pardo-Reoyo, M. Sgagias, K. H. Cowan, L. C. Brody posted to brca1 chk1 damage dna g2m by catcremona on 2009-02-06 01:35:14 as along with 1 person DNAReplication
	Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. [My Copy] Science, Vol. 277, No. 5331. (5 September 1997), pp. 1497-1501. by Y. Sanchez, C. Wong, R. S. Thoma, et al.R. Richman, Z. Wu, H. Piwnica-Worms, S. J. Elledge posted to cdc25 chk1 damage dna by catcremona on 2009-02-06 01:27:36 as along with 1 person DNAReplication
	An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. [My Copy] Mol Cell Biol, Vol. 22, No. 24. (December 2002), pp. 8552-8561. by T. P. Heffernan, D. A. Simpson, A. R. Frank, et al.A. N. Heinloth, R. S. Paules, M. Cordeiro-Stone, W. K. Kaufmann posted to atr chk1 damage dna sphase by catcremona on 2009-02-06 01:26:52 as along with 1 person ecattell
	The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. [My Copy] Genes Dev, Vol. 14, No. 3. (1 February 2000), pp. 289-300. by S. Y. Shieh, J. Ahn, K. Tamai, Y. Taya, C. Prives posted to chk1 chk2 damage dna p52 by catcremona on 2009-02-06 01:21:38 as along with 1 person DNAReplication
	Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. [My Copy] Science (New York, N.Y.), Vol. 286, No. 5442. (5 November 1999), pp. 1166-1171. by Y. Sanchez, J. Bachant, H. Wang, et al.F. Hu, D. Liu, M. Tetzlaff, S. J. Elledge posted to checkpoin chk1 damage dna by catcremona on 2009-02-06 01:19:24 as
	The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. [My Copy] Frontiers in bioscience : a journal and virtual library, Vol. 13 (2008), pp. 5016-5029. by Y. Chen, R. Y. Poon posted to checkpoint chk1 chk2 genome review stability by catcremona on 2008-12-21 11:09:51 as along with 1 person diaz0058
	DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2. [My Copy] Cell cycle (Georgetown, Tex.), Vol. 7, No. 11. (1 June 2008), pp. 1668-1677. by W. H. Zhang, A. Poh, A. A. Fanous, A. Eastman posted to chk1 by johnsonlab on 2008-10-21 17:46:26 as
	Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1. [My Copy] Mol Biol Cell, Vol. 10, No. 4. (April 1999), pp. 833-845. by B. Furnari, A. Blasina, M. N. Boddy, C. H. McGowan, P. Russell posted to cdc25 cds1 chk1 inhibition by catcremona on 2008-05-01 15:12:24 as along with 1 person DNAReplication
	Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. [My Copy] Cancer Res, Vol. 62, No. 9. (1 May 2002), pp. 2483-2487. by H. Wang, X. Wang, X. Y. Zhou, et al.D. J. Chen, G. C. Li, G. Iliakis, Y. Wang posted to chk1 by DNAReplication on 2008-02-07 20:48:01 as
	Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts [My Copy] Molecular Cell, Vol. 6, No. 4. (October 2000), pp. 839-849. by Akiko Kumagai, William G. Dunphy posted to chk1 xenopus by DNAReplication on 2008-02-07 20:11:02 as
	Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. [My Copy] J Biol Chem, Vol. 278, No. 47. (21 November 2003), pp. 46782-46788. by S. Y. Jeong, A. Kumagai, J. Lee, W. G. Dunphy posted to chk1 claspin by DNAReplication on 2008-02-04 01:41:07 as
	Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. [My Copy] Proc Natl Acad Sci U S A, Vol. 101, No. 17. (27 April 2004), pp. 6484-6489. by S. Y. Lin, K. Li, G. S. Stewart, S. J. Elledge posted to atr chk1 claspin by DNAReplication on 2008-02-04 00:32:54 as
	Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. [My Copy] Proc Natl Acad Sci U S A, Vol. 96, No. 24. (23 November 1999), pp. 13777-13782. by N. H. Chehab, A. Malikzay, E. S. Stavridi, T. D. Halazonetis posted to atm atr chk1 chk2 mdm2 p53 by DNAReplication on 2008-02-03 20:41:46 as along with 1 person catcremona
	Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation [My Copy] J. Biol. Chem., Vol. 278, No. 17. (18 April 2003), pp. 14806-14811. by Magtouf Gatei, Katie Sloper, Claus Sorensen, et al.Randi Syljuasen, Jacob Falck, Karen Hobson, Kienan Savage, Jiri Lukas, Bin-Bing Zhou, Jiri Bartek, Kum K. Khanna posted to atm chk1 by DNAReplication on 2008-02-03 18:55:18 as
	Chk1 regulates the density of active replication origins during the vertebrate S phase [My Copy] The EMBO Journal, Vol. aop, No. current. (10 May 2007) by Apolinar Maya-Mendoza, Eva Petermann, David A. F. Gillespie, Keith W. Caldecott, Dean A. Jackson posted to chk1 dna-replication by DNAReplication on 2008-01-30 23:49:34 as
	Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. [My Copy] Nature, Vol. 395, No. 6701. (1 October 1998), pp. 507-510. by Y. Zeng, K. C. Forbes, Z. Wu, S. Moreno, H. Piwnica-Worms, T. Enoch posted to chk1 s-m-checkpoint by DNAReplication on 2008-01-30 20:56:37 as
	Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. [My Copy] Cell Cycle, Vol. 4, No. 10. (October 2005), pp. 1428-1434. by L. Jirmanova, D. V. Bulavin, A. J. Fornace posted to atr chk1 p38 by DNAReplication on 2008-01-15 22:43:58 as
	Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. [My Copy] Mol Cell, Vol. 28, No. 4. (30 November 2007), pp. 624-637. by Y. Zermati, S. Mouhamad, L. Stergiou, et al.B. Besse, L. Galluzzi, S. Boehrer, A. L. Pauleau, F. Rosselli, M. D'Amelio, R. Amendola, M. Castedo, M. Hengartner, J. C. Soria, F. Cecconi, G. Kroemer posted to apaf-1 chk1 by DNAReplication on 2008-01-12 19:24:04 as along with 2 people and 1 group thegoose2 tharris C. elegans / WormBase
	Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. [My Copy] J Biol Chem, Vol. 279, No. 10. (5 March 2004), pp. 8808-8819. by C. P. Ng, H. C. Lee, C. W. Ho, et al.T. Arooz, W. Y. Siu, A. Lau, R. Y. Poon posted to chk1 chk2 by DNAReplication on 2008-01-11 16:56:43 as
	Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. [My Copy] Proc Natl Acad Sci U S A, Vol. 104, No. 10. (6 March 2007), pp. 3805-3810. by K. Zaugg, Y. W. Su, P. T. Reilly, et al.Y. Moolani, C. C. Cheung, R. Hakem, A. Hirao, Q. Liu, S. J. Elledge, T. W. Mak posted to chk1 chk2 knockout-mouse by DNAReplication on 2008-01-08 20:13:30 as
	Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. [My Copy] Curr Biol, Vol. 16, No. 2. (24 January 2006), pp. 150-159. by V. A. Smits, P. M. Reaper, S. P. Jackson posted to chk1 by DNAReplication on 2008-01-03 22:36:11 as
	Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. [My Copy] Genes Dev, Vol. 20, No. 7. (1 April 2006), pp. 772-783. by H. Y. Yoo, S. Y. Jeong, W. G. Dunphy posted to atr chk1 claspin xenopus by DNAReplication on 2008-01-03 21:42:31 as
	Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1 [My Copy] Genes Dev., Vol. 11, No. 24. (15 December 1997), pp. 3387-3400. by Yasushi Saka, Fumiko Esashi, Takahiro Matsusaka, Satoru Mochida, Mitsuhiro Yanagida posted to chk1 crb2 cut5 pombe by DNAReplication on 2008-01-03 20:02:43 as
	Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 [My Copy] Nat Cell Biol, Vol. 5, No. 2. (February 2003), pp. 161-165. by Akiko Kumagai, William G. Dunphy posted to chk1 claspin by DNAReplication on 2008-01-03 01:22:04 as
	Human Claspin Is Required for Replication Checkpoint Control [My Copy] J. Biol. Chem., Vol. 278, No. 32. (8 August 2003), pp. 30057-30062. by Claudia C. Chini, Junjie Chen posted to chk1 claspin s-m-checkpoint by DNAReplication on 2008-01-03 00:58:10 as
	The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. [My Copy] Genes Dev, Vol. 21, No. 12. (15 June 2007), pp. 1472-1477. by S. Delacroix, J. M. Wagner, M. Kobayashi, K. Yamamoto, L. M. Karnitz posted to atr chk1 hus1 rad1 rad9 topbp1 xenopus by DNAReplication on 2008-01-02 20:33:59 as along with 1 person esineva
	The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. [My Copy] J Biol Chem, Vol. 282, No. 38. (21 September 2007), pp. 28036-28044. by J. Lee, A. Kumagai, W. G. Dunphy posted to atr chk1 hus1 rad1 rad9 topbp1 xenopus by DNAReplication on 2008-01-02 20:33:41 as
	The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts [My Copy] J. Cell Biol., Vol. 142, No. 6. (21 September 1998), pp. 1559-1569. by Akiko Kumagai, Zijian Guo, Katayoon H. Emami, Sophie X. Wang, William G. Dunphy posted to chk1 xenopus by DNAReplication on 2008-01-02 17:52:49 as
	The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. [My Copy] J Cell Biol, Vol. 165, No. 2. (26 April 2004), pp. 181-190. by M. Oehlmann, A. J. Score, J. J. Blow posted to cdc6 chk1 s-m-checkpoint xenopus by DNAReplication on 2008-01-02 14:57:35 as
	Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. [My Copy] Mol Cell Biol, Vol. 25, No. 9. (May 2005), pp. 3553-3562. by R. G. Syljuåsen, C. S. Sørensen, L. T. Hansen, et al.K. Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, J. Bartek posted to chk1 dna-replication by DNAReplication on 2008-01-02 02:16:40 as
	TopBP1 activates the ATR-ATRIP complex. [My Copy] Cell, Vol. 124, No. 5. (10 March 2006), pp. 943-955. by A. Kumagai, J. Lee, H. Y. Yoo, W. G. Dunphy posted to atr atrip chk1 topbp1 xenopus by DNAReplication on 2007-12-31 20:44:52 as
	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. [My Copy] Mol Cell Biol, Vol. 26, No. 16. (August 2006), pp. 6056-6064. by S. Liu, S. Bekker-Jensen, N. Mailand, C. Lukas, J. Bartek, J. Lukas posted to atr chk1 claspin gfp- topbp1 by DNAReplication on 2007-12-31 20:39:45 as
	Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. [My Copy] Proc Natl Acad Sci U S A, Vol. 104, No. 38. (18 September 2007), pp. 14929-14934. by A. Errico, V. Costanzo, T. Hunt posted to chk1 claspin tim tipin by DNAReplication on 2007-12-31 20:23:06 as

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atr	35
claspin	25
xenopus	24
dna	14
chk2	12
damage	11
g2-checkpoint	11
brca1	7
cdc25a	7
p53	7
topbp1	7
atm	6
checkpoint	6
knockout-mouse	6
s-m-checkpoint	6
cdc25b	5
rad17	5
replication	5
cdc25c	4
dna-replication	4
fanc-d2	4
fanconi-anemia	4
mcph1	4
pombe	4
wee1	4
14-3-3	3
g2m	3
hus1	3
p38	3
rad1	3
rad9	3
rpa	3
apaf-1	2
atrip	2
cdc2	2
cdc25	2
cdc6	2
cdc7	2
chris	2
crb2	2
cut5	2
dde	2
dna-fiber-analysis	2
fanc-e	2
hclk2	2
intra-s-phase-checkpoint	2
mdm2	2
plk1	2
ppm1d	2
premature-chromatin-condensation	2
pten	2
radioresistant-dna-synthesis	2
spindle-checkpoint	2
tim	2
tipin	2
uv	2
1ia8	1
4n-accumulation	1
antibody	1
arrest	1
btrcp	1
camptothecin	1
cancer	1
cdk1	1
cds1	1
checkpoin	1
checkpoints	1
crystal_structure	1
death	1
degradation	1
dnadamage	1
domain	1
fanc	1
fork	1
geminin	1
genome	1
gfp-	1
h2ax	1
helleday	1
homologous	1
hunan	1
inhibition	1
intestine	1
ir	1
kinase	1
knockout	1
liver	1
mouse	1
p52	1
phosphorylation	1
pp1	1
recombination	1
review	1
s317	1
securin	1
sphase	1
ss	1
stability	1
yeast	1

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