Tag drug_discovery [127 articles] Export

Recent papers classified by the tag drug_discovery.

	Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7. [My Copy] PloS one, Vol. 4, No. 10. (2009) by Tobias Karlberg, Susanne van den Berg, Martin Hammarström, et al.Johanna Sagemark, Ida Johansson, Lovisa Holmberg-Schiavone, Herwig Schüler posted to sgc protein_structure drug_targets drug_discovery crystal_structure by pekrau to the group SGC Stockholm on 2009-11-20 08:43:45 as
	Predicting new molecular targets for known drugs [My Copy] Nature, Vol. 462, No. 7270. (01 November 2009), pp. 175-181. by Michael J. Keiser, Vincent Setola, John J. Irwin, et al.Christian Laggner, Atheir I. Abbas, Sandra J. Hufeisen, Niels H. Jensen, Michael B. Kuijer, Roberto C. Matos, Thuy B. Tran, Ryan Whaley, Richard A. Glennon, Jerome Hert, Kelan L. H. Thomas, Douglas D. Edwards, Brian K. Shoichet, Bryan L. Roth posted to drug_discovery by venancio on 2009-11-16 22:09:43 as along with 15 people and 1 group flbarroso okapi ahmetbakan zufar pablocarb zwang TRHvidsten phoenixzxl qshao Yanno mnishimu tmmurali sjcockell seb1 abhishek_tiwari Journal picks
	Strategies for efficient disruption of metabolism in Mycobacterium tuberculosis from network analysis [My Copy] Mol. BioSyst., Vol. 5, No. 12. (2009), pp. 1740-1751. by Karthik Raman, Rohit Vashisht, Nagasuma Chandra posted to tuberculosis networks fba drug_targets drug_discovery by karthikraman on 2009-11-14 17:19:00 as
	Drug discovery: Predicting promiscuity [My Copy] Nature, Vol. 462, No. 7270. (11 November 2009), pp. 167-168. by Andrew L. Hopkins posted to promiscuity drug_discovery drug by pablocarb on 2009-11-12 09:14:40 as along with 1 person okapi
	Protein kinase inhibitors: contributions from structure to clinical compounds [My Copy] Quarterly Reviews of Biophysics, Vol. 42, No. 01. (2009), pp. 1-40. by Louise N. Johnson posted to mgcb kinases drug_discovery by TimRooney on 2009-11-09 10:38:13 as along with 1 person saradtc
	Integrated functional, gene expression and genomic analysis for the identification of cancer targets. [My Copy] PloS one, Vol. 4, No. 4. (9 April 2009), e5120. by Elizabeth Iorns, Christopher J. Lord, Anita Grigoriadis, et al.Sarah McDonald, Kerry Fenwick, Alan Mackay, Charles A. Mein, Rachael Natrajan, Kay Savage, Narinder Tamber, Jorge S. Reis-Filho, Nicholas C. Turner, Alan Ashworth posted to target rnai integration gene_expression drug_discovery copy-number biomarker by jfr on 2009-11-03 17:11:01 as along with 2 people rdiaz roys
	Targeting cancer with small molecule kinase inhibitors. [My Copy] Nature reviews. Cancer, Vol. 9, No. 1. (01 January 2009), pp. 28-39. by Jianming Zhang, Priscilla L. Yang, Nathanael S. Gray posted to mgcb kinases drug_discovery cancer by TimRooney on 2009-11-02 10:14:58 as along with 5 people saradtc kokphinchooi sschurer renatomilani guhjy
	Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. [My Copy] Nature reviews. Drug discovery, Vol. 8, No. 9. (24 September 2009), pp. 709-723. by Pasi A. Jänne, Nathanael Gray, Jeff Settleman posted to mgcb kinases drug_discovery cancer by TimRooney on 2009-11-02 10:08:55 as along with 3 people guhjy kokphinchooi renatomilani
	The therapeutic potential of phosphatase inhibitors [My Copy] Current Opinion in Chemical Biology, Vol. 13, No. 3. (04 June 2009), pp. 272-283. by Viktor V. Vintonyak, Andrey P. Antonchick, Daniel Rauh, Herbert Waldmann posted to phosphatases mgcb drug_discovery by TimRooney on 2009-11-02 10:07:32 as along with 2 people kokphinchooi guhjy
	Protein kinases \|[mdash]\| the major drug targets of the twenty-first century? [My Copy] Nat Rev Drug Discov, Vol. 1, No. 4. (01 April 2002), pp. 309-315. by Philip Cohen posted to mgcb kinases drug_discovery by TimRooney on 2009-11-02 09:56:03 as along with 2 people saradtc kokphinchooi
	Targeting protein kinases in central nervous system disorders [My Copy] Nature Reviews Drug Discovery, Vol. 8, No. 11. (01 November 2009), pp. 892-909. by Laura K. Chico, Linda J. Van Eldik, D. Martin Watterson posted to mgcb kinases drug_discovery cns by TimRooney on 2009-11-02 09:51:55 as along with 2 people renatomilani kokphinchooi
	Transcription factors as targets for cancer therapy. [My Copy] Nature reviews. Cancer, Vol. 2, No. 10. (October 2002), pp. 740-749. by James E. Darnell posted to transcription_factors drug_discovery cancer_therapy by Zoltan_Barczikay on 2009-10-31 13:19:38 as
	Recent Developments in Fragment-Based Drug Discovery [My Copy] Journal of Medicinal Chemistry, Vol. 51, No. 13. (1 July 2008), pp. 3661-3680. by Miles Congreve, Gianni Chessari, Dominic Tisi, Andrew J. Woodhead posted to review ligand_binding library drug_discovery drug_design by hmk on 2009-10-30 18:46:15 as along with 5 people and 1 group ubcg08l jerome higueruelo vaibhavdixit4 pslee Fragment Based Drug Discovery
	Targeting DNA methylation. [My Copy] Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, No. 12. (15 June 2009), pp. 3938-3946. by Jean-Pierre P. Issa, Hagop M. Kantarjian posted to review methylation epigenetic_therapy drug_discovery by misonneh on 2009-10-29 07:45:57 as
	Catalytic organometallic anticancer complexes [My Copy] Proceedings of the National Academy of Sciences, Vol. 105, No. 33. (19 August 2008), pp. 11628-11633. by Sarah J. Dougan, Abraha Habtemariam, Sarah E. McHale, Simon Parsons, Peter J. Sadler posted to drug_discovery catalytic_drugs anticancer_drugs by Zoltan_Barczikay on 2009-10-27 12:50:04 as
	A Kernel for Open Source Drug Discovery in Tropical Diseases [My Copy] PLoS Negl Trop Dis, Vol. 3, No. 4. (21 April 2009), e418. by Leticia Ortí, Rodrigo J. Carbajo, Ursula Pieper, et al.Narayanan Eswar, Stephen M. Maurer, Arti K. Rai, Ginger Taylor, Matthew H. Todd, Antonio Pineda-Lucena, Andrej Sali, Marc A. Marti-Renom posted to tropical_diseases prioritization drug_discovery by venancio on 2009-10-23 23:39:09 as along with 4 people and 1 group Scis0000002 jmccammon Takao alfons McCammon
	Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery [My Copy] Nature Reviews Drug Discovery, Vol. 8, No. 9. (17 July 2009), pp. 701-708. by Michael R. Barnes, Lee Harland, Steven M. Foord, et al.Matthew D. Hall, Ian Dix, Scott Thomas, Bryn I. Williams-Jones, Cory R. Brouwer posted to drug_discovery by pauladza on 2009-10-21 21:01:38 as along with 2 people dullhunk nicklynch
	Navigating chemical space for biology and medicine [My Copy] Nature, Vol. 432, No. 7019. (15 December 2004), pp. 855-861. by Christopher Lipinski, Andrew Hopkins posted to lipinski drug_discovery by TimRooney on 2009-10-19 11:30:53 as along with 11 people and 5 groups nicklynch sameersoi Effie LamBras BragilMassoud kuhn jxl marcius caporaso blackbart jerome_ucsf_slb NaCTeM EC biomedical-nlp BioinfoCIPF SGU-CIPF
	The impact of FDA guidance on pharmacogenomic data submissions on drug development. [My Copy] IDrugs : the investigational drugs journal, Vol. 8, No. 8. (August 2005), pp. 648-650. by Stephen Little posted to pharmacogenetics guideline fda drug_discovery by misonneh on 2009-10-12 22:36:59 as
	Pharmacogenetics in drug discovery and development: a translational perspective. [My Copy] Nature reviews. Drug discovery, Vol. 7, No. 10. (19 October 2008), pp. 807-817. by Allen D. Roses posted to translation review pharmacogenetics drug_discovery by misonneh on 2009-10-12 22:09:29 as along with 5 people guhjy nicklynch pengchy sg45653 dunnma
	High-Performance Drug Discovery: Computational Screening by Combining Docking and Molecular Dynamics Simulations [My Copy] PLoS Comput Biol, Vol. 5, No. 10. (9 October 2009), e1000528. by Noriaki Okimoto, Noriyuki Futatsugi, Hideyoshi Fuji, et al.Atsushi Suenaga, Gentaro Morimoto, Ryoko Yanai, Yousuke Ohno, Tetsu Narumi, Makoto Taiji posted to optimization molecular_dynamics_simulations md_simulations md drug_discovery drug docking by skywalkerus02 on 2009-10-12 07:05:35 as along with 5 people and 1 group ibuch klexa kentsis reyez barry McCammon
	Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities [My Copy] PLoS Comput Biol, Vol. 5, No. 9. (18 September 2009), e1000512. by Rui-Ru Ji, Heshani de Silva, Yisheng Jin, et al.Robert E. Bruccoleri, Jian Cao, Aiqing He, Wenjun Huang, Paul S. Kayne, Isaac M. Neuhaus, Karl-Heinz Ott, Becky Penhallow, Mark I. Cockett, Michael G. Neubauer, Nathan O. Siemers, Petra Ross-Macdonald posted to transcriptional_profiling plos oct09 drug_discovery by klexa on 2009-10-07 13:40:03 as along with 3 people mingzhi kshameer giovanni
	Blind docking of pharmaceutically relevant compounds using RosettaLigand [My Copy] Protein Science, Vol. 18, No. 9. (24 June 2009), pp. 1998-2002. by Ian W. Davis, Kaushik Raha, Martha S. Head, David Baker posted to sep09 protsci ligand drug_discovery docking by klexa on 2009-10-07 13:36:33 as along with 1 person apaydin
	Epigenetic Therapies Move Into New Territory, but How Exactly Do They Work? [My Copy] J. Natl. Cancer Inst., Vol. 101, No. 19. (7 October 2009), pp. 1300-1301. by Rabiya S. Tuma posted to epigenetics drug_discovery comments chemotherapy by misonneh on 2009-10-07 02:14:53 as
	Perspectives on NMR in drug discovery: a technique comes of age [My Copy] Nature Reviews Drug Discovery, Vol. 7, No. 9. (01 September 2008), pp. 738-745. by Maurizio Pellecchia, Ivano Bertini, David Cowburn, et al.Claudio Dalvit, Ernest Giralt, Wolfgang Jahnke, Thomas L. James, Steve W. Homans, Horst Kessler, Claudio Luchinat, Bernd Meyer, Hartmut Oschkinat, Jeff Peng, Harald Schwalbe, Gregg Siegal posted to review nmr drug_discovery by apaydin on 2009-10-03 19:11:09 as along with 1 person ubcg08l
	Computational chemistry-driven decision making in lead generation [My Copy] Drug Discovery Today, Vol. 11, No. 1-2. (January 2006), pp. 43-50. by Volker Schnecke, Jonas Bostrom posted to library lead drug_discovery 2006 by klexa on 2009-09-29 21:04:32 as along with 1 person daevans
	Streamlining lead discovery by aligning in silico and high-throughput screening [My Copy] Current Opinion in Chemical Biology In Next-generation therapeutics, Vol. 10, No. 4. (August 2006), pp. 343-351. by J. Davies, M. Glick, J. Jenkins posted to screening sbdd lead hts drug_discovery 2006 by klexa on 2009-09-29 21:03:44 as along with 2 people nicklynch daevans
	Integrating molecular design resources within modern drug discovery research: the Roche experience. [My Copy] Drug Discov Today, Vol. 11, No. 7-8. (April 2006), pp. 326-333. by M. Stahl, W. Guba, M. Kansy posted to review drug_discovery 2006 by klexa on 2009-09-29 21:03:20 as along with 4 people JALumley sschurer BragilMassoud daevans
	Structure-based virtual ligand screening with LigandFit: Pose prediction and enrichment of compound collections. [My Copy] Proteins, Vol. 68, No. 3. (15 August 2007), pp. 712-725. by M. Montes, M. A. Miteva, B. O. Villoutreix posted to screening protein-ligand lead drug_discovery docking 2007 by klexa on 2009-09-29 20:56:33 as along with 1 person schlauchi
	Do Structurally Similar Ligands Bind in a Similar Fashion? [My Copy] Journal of Medicinal Chemistry, Vol. 49, No. 23. (1 November 2006), pp. 6716-6725. by Jonas Bostrom, Anders Hogner, Stefan Schmitt posted to solvation similiarity side-chain sbdd protein_flexibility ligand flexibility drug_discovery 2006 by klexa on 2009-09-29 20:45:59 as along with 4 people schlauchi daevans superpyrin nickolay
	Chemical biology: Caught in the activation [My Copy] Nature, Vol. 461, No. 7263. (23 September 2009), pp. 484-485. by Yi Liu posted to kinase drug_discovery by alexknight on 2009-09-28 17:00:14 as along with 1 person boris_aguilar
	Exploring Experimental Sources of Multiple Protein Conformations in Structure-Based Drug Design [My Copy] Journal of the American Chemical Society, Vol. 129, No. 26. (1 July 2007), pp. 8225-8235. by Kelly L. Damm, Heather A. Carlson posted to protein-ensembles drug_discovery by ubcg08l on 2009-09-24 10:07:21 as along with 1 person higueruelo
	Open access chemical and clinical probes to support drug discovery [My Copy] Nature Chemical Biology, Vol. 5, No. 7. (01 July 2009), pp. 436-440. by Aled M. Edwards, Chas Bountra, David J. Kerr, Timothy M. Willson posted to open_access drug_discovery chemical_biology by pekrau on 2009-09-17 17:07:21 as along with 2 people reyez neils
	Open-source science to enable drug discovery [My Copy] Drug Discovery Today, Vol. 13, No. 17-18. (September 2008), pp. 731-733. by A. Edwards posted to structural_biology open_access drug_targets drug_discovery by pekrau on 2009-09-17 10:22:54 as along with 7 people agomez guhjy nicklynch hpiwowar dullhunk zimbo1 psique
	targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. [My Copy] BMC systems biology, Vol. 2, No. 1. (2008) by Karthik Raman, Kalidas Yeturu, Nagasuma Chandra posted to tb drug_discovery by JeremyZucker to the group MetabolicModeling on 2009-09-10 01:19:02 as along with 4 people schwartzjmc shung kshameer druvus
	The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery. [My Copy] EMBO reports, Vol. 10, No. 9. (September 2009), pp. 941-945. by Johan Weigelt posted to sgc open_access medicinal_chemistry drug_targets drug_discovery chemical_biology by pekrau to the group SGC Stockholm on 2009-09-08 14:55:22 as
	Clinical biomarkers in drug discovery and development [My Copy] Nat Rev Drug Discov, Vol. 2, No. 7. (July 2003), pp. 566-580. by Richard Frank, Richard Hargreaves posted to drug_discovery biomarkers by srp33 on 2009-09-04 19:02:53 as along with 1 person misonneh
	Why is cancer drug discovery so difficult? [My Copy] Nat Rev Drug Discov, Vol. 6, No. 2. (08 February 2007), pp. 115-120. by Alexander Kamb, Susan Wee, Christoph Lengauer posted to drug_discovery by srp33 on 2009-09-04 18:48:47 as along with 1 person Petersarkies
	Integrating scientific data for drug discovery and development using the Life Sciences Grid [My Copy] Expert Opinion on Drug Discovery, Vol. 4, No. 6. (June 2009), pp. 687-699. by Ernst R. Dow, James B. Hughes, Susie M. Stephens, Vaibhav A. Narayan, Richard W. Bishop posted to semantics life_science drug_discovery drug_development drug_design data_integration by joergkurtwegner to the group Drug-Design on 2009-09-03 19:05:55 as along with 3 people pekrau dullhunk nicklynch
	Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase [My Copy] Journal of Computer-Aided Molecular Design, Vol. 23, No. 8. (1 August 2009), pp. 491-500. by Melissa Landon, Raquel Lieberman, Quyen Hoang, et al.Shulin Ju, Jose Caaveiro, Susan Orwig, Dima Kozakov, Ryan Brenke, Gwo-Yu Chuang, Dmitry Beglov, Sandor Vajda, Gregory Petsko, Dagmar Ringe posted to mscs ligand jcamd hot-spots fragment drug_discovery crystallography binding aug09 by klexa on 2009-08-20 14:12:24 as along with 1 person reyez
	Recent advances in computer-aided drug design [My Copy] Brief Bioinform, Vol. 10, No. 5. (1 September 2009), pp. 579-591. by Chun M. Song, Shen J. Lim, Joo C. Tong posted to drug_discovery computational bioinformatics by operon on 2009-08-14 21:11:41 as along with 7 people and 1 group mtruksa npt11tpn abhishek_tiwari reyez apaydin kshameer phoenixzxl structural_bioinformatics
	X-ray vs. NMR structures as templates for computational protein design [My Copy] Proteins: Structure, Function, and Bioinformatics, Vol. 77, No. 1. (2009), pp. 97-110. by Michael Schneider, Xiaoran Fu, Amy E. Keating posted to xray structural_model sbdd proteinssfb nmr drug_discovery aug09 by klexa on 2009-08-11 19:25:07 as along with 3 people kgutwin reyez paulschlesinger
	Fragment-based drug discovery [My Copy] Journal of Computer-Aided Molecular Design, Vol. 23, No. 8. (1 August 2009), pp. 453-458. by Wendy Warr posted to jcc fragment drug_discovery aug09 by klexa on 2009-08-11 16:24:48 as
	Drug discovery chemistry: a primer for the non-specialist. [My Copy] Drug discovery today, Vol. 14, No. 15-16. (2 August 2009), pp. 731-744. by Allan M. Jordan, Stephen D. Roughley posted to chemistry computational_chemistry drug_discovery nomenclature review by jerome on 2009-08-03 07:51:41 as along with 4 people and 1 group richardbickerton pmung zimbo1 jmccammon McCammon
	AutoGrow: a novel algorithm for protein inhibitor design. [My Copy] Chemical biology & drug design, Vol. 73, No. 2. (February 2009), pp. 168-178. by Jacob D. Durrant, Rommie E. Amaro, J. Andrew McCammon posted to 2009 autogrow cadd drug_discovery inhibitor protein by klexa on 2009-06-29 15:33:04 as along with 1 person and 2 groups oteri Structural Biology Group TorVergata LOX-1 Receptor
	Recent advances in computer-aided drug design. [My Copy] Briefings in bioinformatics (11 May 2009) by Chun Meng M. Song, Shen Jean J. Lim, Joo Chuan C. Tong posted to 2009 cadd drug_discovery review by klexa on 2009-06-29 15:17:33 as along with 3 people and 2 groups nanonan apaydin barry structural_bioinformatics McCammon
	Automated genome mining for natural products [My Copy] BMC Bioinformatics, Vol. 10, No. 1. (2009), 185. by Michael Li, Peter Ung, James Zajkowski, Sylvie G. Tsodikova, David Sherman posted to biotech data_mining drug_discovery genomics metagenomics by operon on 2009-06-17 17:07:18 as along with 6 people bcondon mitko orzenil gillianturgeon erexhepa neils
	Innovation: How molecular profiling could revolutionize drug discovery [My Copy] Nature Reviews Drug Discovery, Vol. 4, No. 4. (01 April 2005), pp. 345-350. by Roland B. Stoughton, Stephen H. Friend posted to drug_discovery review by jfr on 2009-06-17 16:49:02 as
	A network view of disease and compound screening. [My Copy] Nature reviews. Drug discovery, Vol. 8, No. 4. (April 2009), pp. 286-295. by Eric E. Schadt, Stephen H. Friend, David A. Shaywitz posted to drug_discovery network by oelemento on 2009-06-07 18:00:38 as along with 11 people jbesnard abhishek_tiwari pablocarb richardbickerton sameersoi mingzhi ptrobajo phoenixzxl reyez guhjy sschurer
	Palifermin for oral mucositis after intensive therapy for hematologic cancers. [My Copy] N Engl J Med, Vol. 351, No. 25. (16 December 2004), pp. 2590-2598. by R. Spielberger, P. Stiff, W. Bensinger, et al.T. Gentile, D. Weisdorf, T. Kewalramani, T. Shea, S. Yanovich, K. Hansen, S. Noga, J. McCarty, C. F. LeMaistre, E. C. Sung, B. R. Blazar, D. Elhardt, M. G. Chen, C. Emmanouilides posted to cancer clinical drug_discovery hematology read by absterga on 2009-05-28 04:32:49 as along with 1 person dbs

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review	21
pharmacology	10
aug09	8
cancer	8
read	8
systems_biology	8
docking	7
protein_ligand	7
2006	6
clinical	6
drug_targets	6
fragment	6
kinases	6
malaria	6
mgcb	6
drug_development	5
drug_target	5
jcamd	5
ligand	5
sbdd	5
computational	4
crystallography	4
drug	4
grb2	4
network	4
networks	4
open_access	4
protein_structure	4
sh2	4
structure-based	4
2009	3
binding	3
chemical_biology	3
drug_design	3
genomics	3
kinase	3
lead	3
mb_review	3
neuro	3
nmr	3
protein_flexibility	3
screening	3
stem_cells	3
allostery	2
biomarker	2
biotech	2
cadd	2
cancer_therapy	2
data_integration	2
data_mining	2
drug_access	2
fgf	2
fragments	2
genetics	2
gpcr	2
gpcrs	2
hematology	2
hot-spots	2
hts	2
immunology	2
integration	2
library	2
life_science	2
medicinal_chemistry	2
mm-pbsa	2
molecular_targets	2
mscs	2
oct09	2
pathway	2
pathway_analysis	2
pharmacogenetics	2
plos	2
polypharmacology	2
promiscuity	2
protein	2
protein-ligand	2
protein-protein	2
proteinssfb	2
proteomics	2
protsci	2
psychiatry	2
semantics	2
sep09	2
sgc	2
snps	2
structural_model	2
structure	2
target	2
tb	2
transcriptional_profiling	2
tuberculosis	2
xray	2
chemical_systems	1
chemogenomics	1
depression	1
dna_protein_interactions	1
ppps	1
qsar	1
sysbio	1
transcription_factors	1

Tag drug_discovery [127 articles] Export

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