Tag druggable [35 articles] Export Sort

Recent papers classified by the tag druggable.

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	Physicochemical property profiles of marketed drugs, clinical candidates, and bioactive compounds [My Copy] Bioorganic & Medicinal Chemistry Letters (20 October 2009) by Christian Tyrchan, Niklas Blomberg, Ola Engkvist, Thierry Kogej, Sorel Muresan posted to scissors props druggable 2009 by higueruelo on 2009-10-23 14:49:05 as
	Assessing the druggability of protein-protein interactions by a supervised machine-learning method [My Copy] BMC Bioinformatics, Vol. 10, No. 1. (25 August 2009), 263. by Nobuyoshi Sugaya, Kazuyoshi Ikeda posted to xf sm ppi druggable 2009 by higueruelo on 2009-09-03 14:12:34 as along with 3 people richardbickerton iris_2001 phoenixzxl
	In silico-in vitro screening of protein-protein interactions: towards the next generation of therapeutics. [My Copy] Current pharmaceutical biotechnology, Vol. 9, No. 2. (April 2008), pp. 103-122. by B. O. Villoutreix, K. Bastard, O. Sperandio, et al.R. Fahraeus, J. L. Poyet, F. Calvo, B. Déprez, M. A. Miteva posted to 2009 computational druggable interface ppi sm by higueruelo on 2009-07-29 14:54:32 as along with 1 person flbarroso
	Protein disorder in the human diseasome: unfoldomics of human genetic diseases. [My Copy] BMC genomics, Vol. 10 Suppl 1 (2009) by U. Midic, C. J. Oldfield, A. K. Dunker, Z. Obradovic, V. N. Uversky posted to 2009 disorder druggable by higueruelo on 2009-07-29 14:34:35 as
	Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. [My Copy] BMC genomics, Vol. 10 Suppl 1, No. Suppl 1. (2009), S7. by Vladimir N. Uversky, Christopher J. Oldfield, Uros Midic, et al.Hongbo Xie, Bin Xue, Slobodan Vucetic, Lilia M. Iakoucheva, Zoran Obradovic, A. Keith Dunker posted to 2009 disorder druggable by higueruelo on 2009-07-29 14:33:47 as along with 2 people guhjy kiekyon
	The analysis of the drug-targets based on the topological properties in the human protein-protein interaction network. [My Copy] Journal of drug targeting (16 June 2009) by Mingzhu Zhu, Lei Gao, Xia Li, et al.Zhicheng Liu, Chun Xu, Yuqing Yan, Erin Walker, Wei Jiang, Bin Su, Xiujie Chen, Hui Lin posted to 2009 druggable interface ppi by higueruelo on 2009-06-29 14:14:11 as
	All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples [My Copy] Journal of the American Chemical Society, Vol. 131, No. 13. (8 April 2009), pp. 4622-4627. by Peter S. Kutchukian, Jae S. Yang, Gregory L. Verdine, Eugene I. Shakhnovich posted to 2009 druggable peptides staples by higueruelo on 2009-04-17 15:15:19 as along with 1 person paulschlesinger
	Binding site detection and druggability index from first principles. [My Copy] Journal of medicinal chemistry, Vol. 52, No. 8. (23 April 2009), pp. 2363-2371. by Jesus Seco, F. Javier Luque, Xavier Barril posted to 2009 druggable pocket ppi by higueruelo on 2009-04-01 08:46:56 as along with 3 people ubcg08l sschurer Klapampfer
	A network medicine approach to human disease. [My Copy] FEBS letters (7 March 2009) by Andreas Zanzoni, Montserrat Soler-López, Patrick Aloy posted to 2009 druggable networks review by higueruelo on 2009-03-17 16:48:55 as
	Lipophilicity in PK design: methyl, ethyl, futile. [My Copy] Journal of computer-aided molecular design, Vol. 15, No. 3. (March 2001), pp. 273-286. by H. van de Waterbeemd, D. A. Smith, B. C. Jones posted to druggable props by higueruelo on 2009-03-10 15:18:31 as
	Novel Chemical Space Exploration via Natural Products [My Copy] Journal of Medicinal Chemistry, Vol. 0, No. 0. (0000) by Josefin Rosén, Johan Gottfries, Sorel Muresan, Anders Backlund, Tudor I. Oprea posted to 2009 chemicalspace druggable np props by higueruelo on 2009-03-09 15:17:08 as along with 5 people sorelmuresan zimbo1 sschurer reyez Klapampfer
	The influence of lead discovery strategies on the properties of drug candidates [My Copy] Nature Reviews Drug Discovery, Vol. 8, No. 3. (01 March 2009), pp. 203-212. by Gyorgy M. Keseru, Gergely M. Makara posted to 2009 druggable props review sm by higueruelo on 2009-03-02 18:24:08 as along with 3 people and 1 group hmx pslee cesar McCammon
	Structure-based maximal affinity model predicts small-molecule druggability [My Copy] Nat Biotech, Vol. 25, No. 1. (08 January 2007), pp. 71-75. by Alan C. Cheng, Ryan G. Coleman, Kathleen T. Smyth, et al.Qing Cao, Patricia Soulard, Daniel R. Caffrey, Anna C. Salzberg, Enoch S. Huang posted to druggability structure-based binding druggable file-import-09-03-30 sites by ubcg08l on 2009-02-27 10:54:24 as along with 9 people mingzhi flbarroso phoenixzxl sschurer ucbcjbm jerome yeastyboy willpitt higueruelo
	Predicting druggable binding sites at the protein-protein interface. [My Copy] Drug discovery today (25 November 2008) by Jonathan C C. Fuller, Nicholas J J. Burgoyne, Richard M M. Jackson posted to 2008 druggable pocket ppi review sm xf by higueruelo on 2008-12-02 13:02:38 as along with 4 people flbarroso tbinbal sschurer pslee
	The influence of drug-like concepts on decision-making in medicinal chemistry [My Copy] Nature Reviews Drug Discovery In Nat Rev Drug Discov, Vol. 6, No. 11. (01 November 2007), pp. 881-890. by Paul D. Leeson, Brian Springthorpe posted to 2007 druggable props by higueruelo on 2008-09-25 11:36:32 as along with 3 people rbaron pslee nicklynch
	Chemical Substructures that Enrich for Biological Activity. [My Copy] Bioinformatics (Oxford, England) (11 September 2008) by Justin Klekota, Frederick P P. Roth posted to 2008 druggable fragments by higueruelo on 2008-09-24 13:38:52 as along with 6 people Yanno raiyar zimbo1 dullhunk thanatos massivemayhem
	Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. [My Copy] Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Vol. 361, No. 1467. (29 March 2006), pp. 413-423. by T. L. Blundell, B. L. Sibanda, R. W. Montalvão, et al.S. Brewerton, V. Chelliah, C. L. Worth, N. J. Harmer, O. Davies, D. Burke posted to 2006 druggable fragments ppi review by higueruelo on 2008-09-24 11:26:44 as
	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings [My Copy] Advanced Drug Delivery Reviews In In Vitro Models for Selection of Development Candidates, Vol. 23, No. 1-3. (15 January 1997), pp. 3-25. by C. Lipinski posted to 1997 druggable by higueruelo on 2008-09-18 14:41:45 as along with 1 person daevans
	Molecular properties that influence the oral bioavailability of drug candidates. [My Copy] Journal of medicinal chemistry, Vol. 45, No. 12. (6 June 2002), pp. 2615-2623. by D. F. Veber, S. R. Johnson, H. Y. Cheng, B. R. Smith, K. W. Ward, K. D. Kopple posted to 2002 druggable by higueruelo on 2008-09-18 14:31:25 as along with 1 person JALumley
	Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance [My Copy] Journal of Medicinal Chemistry, Vol. 50, No. 4. (1 February 2007), pp. 726-741. by Michael J. Hartshorn, Marcel L. Verdonk, Gianni Chessari, et al.Suzanne C. Brewerton, Wijnand T. M. Mooij, Paul N. Mortenson, Christopher W. Murray posted to 2007 docking druggable sm-prot by higueruelo on 2008-09-15 09:39:31 as along with 9 people flbarroso GermanErlenkamp massivemayhem BragilMassoud daevans ramensky hmk superpyrin thanatos
	The druggable genome. [My Copy] Nat Rev Drug Discov, Vol. 1, No. 9. (September 2002), pp. 727-730. by A. L. Hopkins, C. R. Groom posted to 2002 druggable by higueruelo on 2008-04-28 14:22:55 as along with 8 people and 1 group bicko semin richardbickerton kuhn apostola dullhunk caporaso thanatos biomedical-nlp
	New Method for the Assessment of All Drug-Like Pockets Across a Structural Genome. [My Copy] J Comput Biol (11 March 2008) by George Nicola, Colin A A. Smith, Ruben Abagyan posted to 2008 druggable xf by higueruelo on 2008-03-13 11:32:36 as along with 1 person shung
	Identification of hot spots within druggable binding regions by computational solvent mapping of proteins. [My Copy] Journal of medicinal chemistry, Vol. 50, No. 6. (22 March 2007), pp. 1231-1240. by Melissa R. Landon, David R. Lancia, Jessamin Yu, Spencer C. Thiel, Sandor Vajda posted to binding druggable sites by willpitt on 2008-02-28 10:16:17 as along with 3 people ubcg08l bicko tjimenez
	A simple and fuzzy method to align and compare druggable ligand-binding sites [My Copy] Proteins: Structure, Function, and Bioinformatics, Vol. 9999, No. 9999. (2007), NA. by Claire Schalon, Jean-Sébastien Surgand, Esther Kellenberger, Didier Rognan posted to binding druggable sites by willpitt on 2008-02-28 10:03:39 as along with 3 people tjimenez bicko nickolay
	The application of FAST-NMR for the identification of novel drug discovery targets. [My Copy] Drug Discov Today, Vol. 13, No. 3-4. (February 2008), pp. 172-179. by R. Powers, K. A. Mercier, J. C. Copeland posted to 2008 druggable nmr by higueruelo on 2008-02-19 22:50:32 as
	How many drug targets are there? [My Copy] Nature Reviews Drug Discovery, Vol. 5, No. 12., pp. 993-996. by John P. Overington, Bissan Al-Lazikani, Andrew L. Hopkins posted to 2006 druggable by higueruelo on 2008-02-04 18:17:30 as along with 10 people and 1 group BragilMassoud cannin kuhn bicko mingzhi srp33 ramensky aheilbut gemmalholliday ajaymalik libr
	Towards drugs targeting multiple proteins in a systems biology approach. [My Copy] Curr Top Med Chem, Vol. 7, No. 10. (2007), pp. 943-951. by O. Keskin, A. Gursoy, B. Ma, R. Nussinov posted to 2007 druggable systemsbio by higueruelo on 2008-02-03 11:06:12 as along with 1 person bicko
	Protein-protein interactions in human disease. [My Copy] Current opinion in structural biology, Vol. 15, No. 4. (August 2005), pp. 441-446. by Daniel P. Ryan, Jacqueline M. Matthews posted to 2005 druggable ppi review by higueruelo on 2008-02-03 10:59:32 as along with 2 people bicko marti
	Drug discovery beyond the 'rule-of-five'. [My Copy] Curr Opin Biotechnol, Vol. 18, No. 6. (December 2007), pp. 478-488. by M. Q. Zhang, B. Wilkinson posted to 2007 druggable sm by higueruelo on 2008-01-13 19:15:02 as
	Statistical Analysis of the Effects of Common Chemical Substituents on Ligand Potency [My Copy] J. Med. Chem. (4 January 2008) by Philip J. Hajduk, Daryl R. Sauer posted to 2008 abbott common-substituents druggable sm by higueruelo on 2008-01-10 12:07:26 as along with 3 people jerome massivemayhem JALumley
	Large scale analysis of protein-binding cavities using self-organizing maps and wavelet-based surface patches to describe functional properties, selectivity discrimination, and putative cross-reactivity. [My Copy] Proteins, Vol. 71, No. 3. (15 May 2008), pp. 1288-1306. by Katrin Kupas, Alfred Ultsch, Gerhard Klebe posted to 2007 druggable pocket by higueruelo on 2007-12-06 12:27:46 as along with 5 people and 2 groups oteri rschulz nickolay sobolevnrm carlescorbi Structural Biology Group TorVergata baker-group
	Binding Response: A Descriptor for Selecting Ligand Binding Site on Protein Surfaces [My Copy] J. Chem. Inf. Model., Vol. 47, No. 6. (26 November 2007), pp. 2303-2315. by S. Zhong, A. D. Mackerell posted to 2007 druggable interface pocket by higueruelo on 2007-12-06 12:07:07 as
	Strategies to search and design stabilizers of protein-protein interactions: A feasibility study. [My Copy] Proteins (28 March 2007) by Peter Block, Nils Weskamp, Alexander Wolf, Gerhard Klebe posted to 2007 druggable interface ppi xf by higueruelo on 2007-12-01 19:28:12 as along with 3 people bicko willpitt allmensch
	Druggability Indices for Protein Targets Derived from NMR-Based Screening Data [My Copy] Journal of Medicinal Chemistry, Vol. 48, No. 7. (1 April 2005), pp. 2518-2525. by Philip J. Hajduk, Jeffrey R. Huth, Stephen W. Fesik posted to 2005 druggable exp nmr by higueruelo on 2007-10-06 14:23:15 as along with 3 people and 1 group ubcg08l kshameer caporaso biomedical-nlp
	Predicting protein druggability [My Copy] Drug Discovery Today, Vol. 10, No. 23-24. (December 2005), pp. 1675-1682. by P. Hajduk, J. Huth, C. Tse posted to 2005 druggable nmr review by higueruelo on 2007-10-06 14:14:40 as along with 5 people and 1 group ubcg08l tjimenez bicko caporaso massivemayhem biomedical-nlp

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Tag druggable [35 articles] Export Sort

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