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Tag gpcr [389 articles]

Recent papers classified by the tag gpcr.
  • Structures and spectral signatures of protonated water networks in bacteriorhodopsin.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 6980-6985.
    by G Mathias, D Marx
    posted to activation gpcr protonation retinal_binding_proteins rhodopsin theory water by xdeupi on 2007-06-11 10:25:44 as *** along with 1 person and 1 group saravan LabCompMed
  • Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling.
    J Comput Aided Mol Des, Vol. 20, No. 7-8. (g 2006), pp. 449-461.
    by F Fanelli, PG De Benedetti
    posted to gpcr modeling review by xdeupi on 2007-03-26 10:31:45 as ** along with 1 group LabCompMed
  • G-protein coupled receptor structure.
    Biochim Biophys Acta (10 October 2006)
    by Philip L L Yeagle, Arlene D D Albert
    posted to activation gpcr review rhodopsin structure by xdeupi on 2006-11-17 20:57:15 as ***** along with 4 people and 1 group gcaltabiano merj superpyrin adamsdi LabCompMed
  • Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.
    J Comput Aided Mol Des (7 November 2006)
    by Marta Filizola, Simon X Wang, Harel Weinstein
    posted to activation dynamics gpcr lipids md membrane rhodopsin structure by xdeupi on 2006-11-14 16:42:29 as ** along with 1 group LabCompMed
  • Method To Assess Packing Quality of Transmembrane alpha-Helices in Proteins. 1. Parametrization Using Structural Data.
    J Chem Inf Model (20 March 2007)
    by Anton O Chugunov, Valery N Novoseletsky, Dmitry E Nolde, Alexander S Arseniev, Roman G Efremov
    posted to gpcr membrane_proteins modeling structure by xdeupi on 2007-03-26 10:07:02 as ** along with 1 person and 1 group superpyrin LabCompMed
  • Constitutive activity and inverse agonism at the alpha1adrenoceptors.
    Biochem Pharmacol, Vol. 73, No. 8. (15 April 2007), pp. 1076-1083.
    by S Cotecchia
    posted to activation gpcr review by xdeupi on 2007-06-02 19:31:15 as ** along with 1 group LabCompMed
  • Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base
    BMC Bioinformatics, Vol. 8 (30 May 2007), 177.
    by Lucy Skrabanek, Marta Murcia, Michel Bouvier, Lakshmi Devi, Susan R George, Martin J Lohse, Graeme Milligan, Richard Neubig, Krzysztof Palczewski, Marc Parmentier, Jean-Philippe Pin, Gerrit Vriend, Jonathan A Javitch, Fabien Campagne, Marta Filizola
    posted to dimer gpcr review by xdeupi on 2007-06-02 19:25:57 as ** along with 1 group LabCompMed
  • The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy.
    J Biol Chem, Vol. 278, No. 50. (12 December 2003), pp. 50217-50225.
    by A Krebs, PC Edwards, C Villa, J Li, GF Schertler
    posted to crystallography gpcr membrane rhodopsin structure by xdeupi on 2006-07-25 15:17:32 as ** along with 1 group LabCompMed
  • Structure-function of alpha1-adrenergic receptors.
    Biochem Pharmacol, Vol. 73, No. 8. (15 April 2007), pp. 1051-1062.
    by DM Perez
    posted to activation gpcr review by xdeupi on 2007-06-02 19:21:05 as ** along with 1 group LabCompMed
  • Mechanisms of Inter- and Intramolecular Communication in GPCRs and G Proteins
    J. Am. Chem. Soc. (12 March 2008)
    by F Raimondi, M Seeber, PG Debenedetti, F Fanelli
    posted to gproteins gpcr docking activation by xdeupi on 2008-05-03 17:09:50 as ** along with 1 person paulschlesinger
  • G protein coupled receptor structure and activation.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 794-807.
    by BK Kobilka
    posted to activation b2ar gpcr review switch by xdeupi on 2007-06-02 19:19:32 as ** along with 4 people and 2 groups jyuh Fritz merj adamsdi neurolit LabCompMed
  • Interacting Residues in an Activated State of a G Protein-coupled Receptor
    J. Biol. Chem., Vol. 281, No. 4. (27 January 2006), pp. 2263-2272.
    by Yong-Hun Lee, Fred Naider, Jeffrey M Becker
    posted to activation gpcr by xdeupi on 2006-01-23 17:17:33 as *** along with 1 group LabCompMed
  • G-protein-coupled receptor signalling through protein networks.
    Biochem Soc Trans, Vol. 35, No. Pt 1. (February 2007), pp. 23-27.
    by AD Strosberg, C Nahmias
    posted to b2ar gpcr pharmacology review structure by xdeupi on 2007-06-29 21:10:57 as ** along with 1 group LabCompMed
  • Latest development in drug discovery on G protein-coupled receptors.
    Curr Protein Pept Sci, Vol. 7, No. 5. (October 2006), pp. 465-470.
    by K Lundstrom
    posted to drug gpcr review by xdeupi on 2006-11-04 12:42:42 as ** along with 1 person and 1 group denissohy LabCompMed
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 group LabCompMed
  • A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors.
    Proteins, Vol. 63, No. 4. (1 June 2006), pp. 1018-1030.
    by K Ye, EW Lameijer, MW Beukers, AP Ijzerman
    posted to activation gpcr sequence transmembrane by xdeupi on 2006-07-24 10:21:33 as **** along with 2 people and 1 group cen4ik cat_worth LabCompMed
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • Melanocortin-1 receptor structure and functional regulation
    Pigment Cell Research, Vol. 18, No. 6. (December 2005), pp. 393-410.
    by Jose C Garcia-Borron, Berta L Sanchez-Laorden, Celia Jimenez-Cervantes
    posted to gpcr structure by xdeupi on 2005-11-11 22:11:21 as ** along with 1 group LabCompMed
  • Determination of network of residues that regulate allostery in protein families using sequence analysis.
    Protein Sci, Vol. 15, No. 2. (February 2006), pp. 258-268.
    by RI Dima, D Thirumalai
    posted to activation gpcr structure by xdeupi on 2006-01-30 09:31:44 as ***** along with 5 people and 1 group gbart nirfriedman choonpeng tale mingzhi LabCompMed
  • Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling.
    BMC Biol, Vol. 3, No. 1. (2005)
    by K Scearce-Levie, MD Lieberman, HH Elliott, BR Conklin
    posted to gpcr internalization by xdeupi on 2006-01-30 09:25:41 as ** along with 1 group LabCompMed
  • GRK specificity for beta -arrestin recruitment to the beta 2-adrenergic receptor revealed by fluorescence resonance energy transfer.
    J Biol Chem (10 May 2006)
    by Jonathan D D Violin, Xiu-Rong R Ren, Robert J J Lefkowitz
    posted to arrestin b2ar fret gpcr by xdeupi on 2006-09-23 11:20:25 as *** along with 1 person and 1 group tkershaw LabCompMed
  • Structure Modeling of All Identified G Protein-Coupled Receptors in the Human Genome.
    PLoS Comput Biol, Vol. 2, No. 2. (17 February 2006)
    by Yang Zhang, Mark E E Devries, Jeffrey Skolnick
    posted to genome gpcr modeling structure by xdeupi on 2006-03-01 10:00:31 as ** along with 3 people and 1 group allanlo jfmuggs superpyrin LabCompMed
  • Molecular simulations and lipid-protein interactions: potassium channels and other membrane proteins.
    Biochem Soc Trans, Vol. 33, No. Pt 5. (October 2005), pp. 916-920.
    by MS Sansom, PJ Bond, SS Deol, A Grottesi, S Haider, ZA Sands
    posted to gpcr md membrane by xdeupi on 2005-11-04 22:45:26 as *** along with 1 person and 1 group dimka LabCompMed
  • Expression of Functional G Protein-Coupled Receptors in Photoreceptors of Transgenic Xenopus laevis.
    Biochemistry, Vol. 44, No. 44. (8 November 2005), pp. 14509-14518.
    by L Zhang, D Salom, J He, A Okun, J Ballesteros, K Palczewski, N Li
    posted to crystallography expression gpcr by xdeupi on 2005-11-04 22:17:03 as ** along with 1 group LabCompMed
  • notes Molecular tinkering of G protein-coupled receptors: an evolutionary success.
    EMBO J, Vol. 18, No. 7. (1 April 1999), pp. 1723-1729.
    by J Bockaert, JP Pin
    posted to evolution genome gpcr by xdeupi on 2006-05-26 16:33:05 as ** along with 2 people and 1 group tkershaw merj LabCompMed
  • Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.
    Trends Pharmacol Sci (28 October 2005)
    by Tommaso Costa, Susanna Cotecchia
    posted to activation cam gpcr by xdeupi on 2005-11-04 22:00:17 as **** along with 1 group LabCompMed
  • The physiological significance of constitutive receptor activity.
    Trends Pharmacol Sci (28 October 2005)
    by Terry Kenakin
    posted to activation cam gpcr by xdeupi on 2005-11-04 21:59:07 as **** along with 1 group LabCompMed
  • New concepts in drug discovery: collateral efficacy and permissive antagonism.
    Nat Rev Drug Discov, Vol. 4, No. 11. (November 2005), pp. 919-927.
    by T Kenakin
    posted to activation agonist ccr5 gpcr ligands by xdeupi on 2005-11-04 21:57:24 as ** along with 1 group LabCompMed
  • Multiple signaling states of G-protein-coupled receptors.
    Pharmacol Rev, Vol. 57, No. 2. (June 2005), pp. 147-161.
    by DM Perez, SS Karnik
    posted to activation agonist gpcr pharmacology review rhodopsin switch by xdeupi on 2007-04-26 14:57:25 as ***** along with 1 group LabCompMed
  • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.
    Mol Pharmacol, Vol. 63, No. 6. (June 2003), pp. 1256-1272.
    by R Fredriksson, MC Lagerström, LG Lundin, HB Schiöth
    posted to evolution genome gpcr sequence by xdeupi on 2006-05-29 12:28:55 as read along with 2 people and 1 group happy_manatee adamsdi LabCompMed
  • The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 913-922.
    by C Ribas, P Penela, C Murga, A Salcedo, C García-Hoz, M Jurado-Pueyo, I Aymerich, F Mayor
    posted to activation arrestin gpcr grk by xdeupi on 2007-07-30 14:59:43 as ** along with 1 group LabCompMed
  • Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region.
    The Journal of biological chemistry (6 May 2008)
    by Tatsuro Shimamura, Kenji Hiraki, Naoko Takahashi, Tetsuya Hori, Hideo Ago, Katsuyoshi Masuda, Koji Takio, Masaji Ishiguro, Masashi Miyano
    posted to xray structure rhodopsin gpcr cterm crystallography by xdeupi on 2008-05-13 16:19:24 as ** along with 1 group LabCompMed
  • Peptide design and structural characterization of a GPCR loop mimetic.
    Biopolymers (18 April 2007)
    by Truc-Chi T C Pham, Richard W W Kriwacki, Abby L L Parrill
    posted to gpcr loops modeling structure by xdeupi on 2007-04-23 10:24:23 as ** along with 1 group LabCompMed
  • The identification of ligands at orphan G-protein coupled receptors.
    Annu Rev Pharmacol Toxicol, Vol. 44 (2004), pp. 43-66.
    by A Wise, SC Jupe, S Rees
    posted to drug gpcr ligands by xdeupi on 2006-03-01 16:35:26 as ** along with 1 group LabCompMed
  • The first extracellular loop of the Saccharomyces cerevisiae GPCR STE2P undergoes a conformational change upon ligand binding.
    J Biol Chem (9 February 2007)
    by Melinda Hauser, Sarah Kauffman, Byung-Kwon K Lee, Fred Naider, Jeffrey M M Becker
    posted to activation binding gpcr loops by xdeupi on 2007-02-20 10:09:06 as ** along with 1 group LabCompMed
  • Structural models of class a g protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.
    Curr Top Med Chem, Vol. 7, No. 10. (2007), pp. 999-1006.
    by X Deupi Nicole Dölker María Luz López-Rodríguez Mercedes Campillo Juan A Ballesteros And Leonardo Pardo, N Dölker, ML López-Rodríguez, M Campillo, JA Ballesteros, L Pardo
    posted to binding gpcr modeling plasticity structure by xdeupi on 2007-05-28 08:51:54 as ** along with 1 group LabCompMed
  • G-protein-coupled receptors: past, present and future.
    Br J Pharmacol, Vol. 147 Suppl 1 (January 2006)
    by SJ Hill
    posted to gpcr by xdeupi on 2006-03-01 16:33:55 as ***** along with 3 people and 2 groups allanlo Fritz merj neurolit LabCompMed
  • A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors.
    Proteins, Vol. 62, No. 2. (1 February 2006), pp. 509-538.
    by JS Surgand, J Rodrigo, E Kellenberger, D Rognan
    posted to binding gpcr ligands transmembrane by xdeupi on 2006-03-01 16:33:01 as ***** along with 1 group LabCompMed
  • Synthesis of TOAC spin-labeled proteins and reconstitution in lipid membranes.
    Nat Protoc, Vol. 2, No. 1. (2007), pp. 42-49.
    by CB Karim, Z Zhang, DD Thomas
    posted to dynamics gpcr toac by xdeupi on 2007-04-10 19:30:43 as ** along with 1 group LabCompMed
  • Initial sequencing and analysis of the human genome
    Nature, Vol. 409, No. 6822. (15 February 2001), pp. 860-921.
    by Michael J Morgan
    posted to gpcr genome by xdeupi on 2007-01-22 18:06:19 as ** along with 18 people and 3 groups brant Cortel dragonrez jnemecek gg bicko Dax42 aprasad yas balajis dullhunk dgront djkt timflutre olympos nagendraproj incovoma yoanjacquemin Proteinkinases T_lab LabCompMed
  • A GPCR that is not "DRY".
    Mol Pharmacol, Vol. 68, No. 1. (July 2005), pp. 1-3.
    by CA Flanagan
    posted to activation dry gpcr ionic switch tm3 by xdeupi on 2006-05-23 12:08:02 as **** along with 1 group LabCompMed
  • Heterologous GPCR Expression: A Bottleneck to Obtaining Crystal Structures.
    Biotechnol Prog (31 March 2007)
    by Emily C McCusker, Steven E Bane, Michelle A O'malley, Anne S Robinson
    posted to crystallography gpcr review by xdeupi on 2007-04-10 19:18:56 as ** along with 1 group LabCompMed
  • Crystallizing thinking about the beta2-adrenergic receptor.
    Mol Pharmacol (31 January 2008)
    by Arun K K Shukla, Jin-Peng P Sun, Robert J J Lefkowitz
    posted to review gpcr crystallography b2ar by xdeupi on 2008-05-13 16:09:07 as ** along with 2 people merj tkershaw
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as ** along with 4 people and 1 group yaredo kuhn massivemayhem Ao_Li2007 LabCompMed
  • The sequence of the human genome.
    Science, Vol. 291, No. 5507. (16 February 2001), pp. 1304-1351.
    by JC Venter, MD Adams, EW Myers, PW Li, RJ Mural, GG Sutton, HO Smith, M Yandell, CA Evans, RA Holt, JD Gocayne, P Amanatides, RM Ballew, DH Huson, JR Wortman, Q Zhang, CD Kodira, XH Zheng, L Chen, M Skupski, G Subramanian, PD Thomas, J Zhang, GL Gabor Miklos, C Nelson, S Broder, AG Clark, J Nadeau, VA McKusick, N Zinder, AJ Levine, RJ Roberts, M Simon, C Slayman, M Hunkapiller, R Bolanos, A Delcher, I Dew, D Fasulo, M Flanigan, L Florea, A Halpern, S Hannenhalli, S Kravitz, S Levy, C Mobarry, K Reinert, K Remington, J Abu-Threideh, E Beasley, K Biddick, V Bonazzi, R Brandon, M Cargill, I Chandramouliswaran, R Charlab, K Chaturvedi, Z Deng, V Di Francesco, P Dunn, K Eilbeck, C Evangelista, AE Gabrielian, W Gan, W Ge, F Gong, Z Gu, P Guan, TJ Heiman, ME Higgins, RR Ji, Z Ke, KA Ketchum, Z Lai, Y Lei, Z Li, J Li, Y Liang, X Lin, F Lu, GV Merkulov, N Milshina, HM Moore, AK Naik, VA Narayan, B Neelam, D Nusskern, DB Rusch, S Salzberg, W Shao, B Shue, J Sun, Z Wang, A Wang, X Wang, J Wang, M Wei, R Wides, C Xiao, C Yan, A Yao, J Ye, M Zhan, W Zhang, H Zhang, Q Zhao, L Zheng, F Zhong, W Zhong, S Zhu, S Zhao, D Gilbert, S Baumhueter, G Spier, C Carter, A Cravchik, T Woodage, F Ali, H An, A Awe, D Baldwin, H Baden, M Barnstead, I Barrow, K Beeson, D Busam, A Carver, A Center, ML Cheng, L Curry, S Danaher, L Davenport, R Desilets, S Dietz, K Dodson, L Doup, S Ferriera, N Garg, A Gluecksmann, B Hart, J Haynes, C Haynes, C Heiner, S Hladun, D Hostin, J Houck, T Howland, C Ibegwam, J Johnson, F Kalush, L Kline, S Koduru, A Love, F Mann, D May, S McCawley, T McIntosh, I McMullen, M Moy, L Moy, B Murphy, K Nelson, C Pfannkoch, E Pratts, V Puri, H Qureshi, M Reardon, R Rodriguez, YH Rogers, D Romblad, B Ruhfel, R Scott, C Sitter, M Smallwood, E Stewart, R Strong, E Suh, R Thomas, NN Tint, S Tse, C Vech, G Wang, J Wetter, S Williams, M Williams, S Windsor, E Winn-Deen, K Wolfe, J Zaveri, K Zaveri, JF Abril, R Guigó, MJ Campbell, KV Sjolander, B Karlak, A Kejariwal, H Mi, B Lazareva, T Hatton, A Narechania, K Diemer, A Muruganujan, N Guo, S Sato, V Bafna, S Istrail, R Lippert, R Schwartz, B Walenz, S Yooseph, D Allen, A Basu, J Baxendale, L Blick, M Caminha, J Carnes-Stine, P Caulk, YH Chiang, M Coyne, C Dahlke, A Mays, M Dombroski, M Donnelly, D Ely, S Esparham, C Fosler, H Gire, S Glanowski, K Glasser, A Glodek, M Gorokhov, K Graham, B Gropman, M Harris, J Heil, S Henderson, J Hoover, D Jennings, C Jordan, J Jordan, J Kasha, L Kagan, C Kraft, A Levitsky, M Lewis, X Liu, J Lopez, D Ma, W Majoros, J McDaniel, S Murphy, M Newman, T Nguyen, N Nguyen, M Nodell, S Pan, J Peck, M Peterson, W Rowe, R Sanders, J Scott, M Simpson, T Smith, A Sprague, T Stockwell, R Turner, E Venter, M Wang, M Wen, D Wu, M Wu, A Xia, A Zandieh, X Zhu
    posted to gpcr genome by xdeupi on 2007-01-22 17:48:23 as ** along with 20 people and 3 groups sunliu granujilla Neeperando CitoJam renatomilani frohike brant Cortel jwortman jnemecek bicko Dax42 yas balajis arcticrasta dgront olympos incovoma naegele mimulus_99 Proteinkinases T_lab LabCompMed
  • The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.
    Annu Rev Pharmacol Toxicol, Vol. 42 (2002), pp. 437-467.
    by L Shi, JA Javitch
    posted to agonist binding ecl2 gpcr helix loops transmembrane by xdeupi on 2005-11-01 01:00:19 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
    J Biol Chem, Vol. 276, No. 31. (3 August 2001), pp. 29171-29177.
    by JA Ballesteros, AD Jensen, G Liapakis, SG Rasmussen, L Shi, U Gether, JA Javitch
    posted to activation b2ar gpcr helix ionic lock pro-kink switch tm3 tm6 by xdeupi on 2005-11-01 00:58:31 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • A molecular dissection of the glycoprotein hormone receptors.
    Trends Biochem Sci, Vol. 29, No. 3. (March 2004), pp. 119-126.
    by G Vassart, L Pardo, S Costagliola
    posted to gpcr hormone structure thyrotropin by xdeupi on 2006-06-20 12:16:16 as ** along with 1 person and 1 group ndoelker LabCompMed
  • Systematic analysis of the entire second extracellular loop of the V1a vasopressin receptor: Key residues, conserved throughout a G-protein-coupled receptor family, identified.
    J Biol Chem (2 April 2007)
    by Matthew Conner, Stuart R R Hawtin, John Simms, Denise L L Wootten, Zoe Lawson, Alex C C Conner, Rosemary A A Parslow, Mark Wheatley
    posted to activation amine binding ecl2 gpcr loops by xdeupi on 2007-04-10 18:59:06 as ***** along with 1 group LabCompMed
  • "Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.
    Biochem Pharmacol, Vol. 73, No. 6. (15 March 2007), pp. 737-751.
    by CP Nelson, RA Challiss
    posted to agonist gpcr ligands pharmacology by xdeupi on 2007-04-10 18:54:26 as ** along with 1 person and 2 groups Fritz neurolit LabCompMed
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