Tag herg [54 articles] Export

Recent papers classified by the tag herg.

	Action Potential Initiation in the Hodgkin-Huxley Model [My Copy] PLoS Comput Biol, Vol. 5, No. 1. (16 January 2009), e1000265. by Lucy J. Colwell, Michael P. Brenner posted to herg potential by agomez on 2009-03-21 00:04:25 as along with 1 person markoffkin
	Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. [My Copy] Biochemical and biophysical research communications, Vol. 373, No. 2. (22 August 2008), pp. 309-314. by J. Nanduri, N. Wang, P. Bergson, G. Yuan, E. Ficker, N. R. Prabhakar posted to herg metabolism ros by agomez on 2009-03-20 23:13:17 as
	Estimation of hERG inhibition of drug candidates using multivariate property and pharmacophore SAR [My Copy] Bioorganic & Medicinal Chemistry, Vol. 15, No. 18. (15 September 2007), pp. 6182-6192. by S. Johnson, H. Yue, M. Conder, et al.H. Shi, A. Doweyko, J. Lloyd, P. Levesque posted to herg by LamBras on 2008-12-21 12:44:54 as
	Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships [My Copy] J. Med. Chem., Vol. 51, No. 5. (13 March 2008), pp. 1162-1178. by Igor Shamovsky, Stephen Connolly, Laurent David, et al.Svetlana Ivanova, Bo Nordén, Brian Springthorpe, Klaus Urbahns posted to herg lipophilicity by superpyrin on 2008-05-22 08:37:19 as
	Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus [My Copy] European Journal of Clinical Pharmacology, Vol. 57, No. 3. (12 June 2001), pp. 185-209. by Fabrizio De Ponti, Elisabetta Poluzzi, Nicola Montanaro posted to herg by LamBras on 2008-04-16 13:21:28 as
	Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K+ Channel Blockers [My Copy] J. Med. Chem., Vol. 45, No. 18. (29 August 2002), pp. 3844-3853. by A. Cavalli, E. Poluzzi, F. De Ponti, M. Recanatini posted to herg by LamBras on 2008-04-16 13:20:00 as
	New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies [My Copy] Bioorganic & Medicinal Chemistry, Vol. 14, No. 9. (1 May 2006), pp. 3160-3173. by Ramy Farid, Tyler Day, Richard A. Friesner, Robert A. Pearlstein posted to docking herg homology_modeling by LamBras on 2008-04-07 15:25:44 as along with 1 person daevans
	Dofetilide block involves interactions with open and inactivated states of HERG channels. [My Copy] Pflugers Arch, Vol. 443, No. 4. (February 2002), pp. 520-531. by M. Weerapura, T. E. Hébert, S. Nattel posted to herg by superpyrin on 2008-04-06 07:31:42 as along with 1 person tomb
	Structural determinants of HERG channel block by clofilium and ibutilide. [My Copy] Molecular pharmacology, Vol. 66, No. 2. (August 2004), pp. 240-249. by M. Perry, M. J. de Groot, R. Helliwell, et al.D. Leishman, M. Tristani-Firouzi, M. C. Sanguinetti, J. Mitcheson posted to herg by superpyrin on 2008-04-02 14:43:57 as
	High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology [My Copy] Nature Reviews Drug Discovery, Vol. 7, No. 4., pp. 358-368. by John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev, Robert Arias posted to herg ion-channel screening by superpyrin on 2008-04-02 08:31:41 as
	HERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study [My Copy] Progress in Biophysics and Molecular Biology, Vol. 86, No. 2. (October 2004), pp. 205-233. by William Bains, Antranig Basman, Cat White posted to herg by superpyrin on 2008-04-01 16:45:45 as
	Predictive in silico modeling for hERG channel blockers [My Copy] Drug Discovery Today, Vol. 10, No. 2. (15 January 2005), pp. 149-155. by Alex M. Aronov posted to herg by superpyrin on 2008-04-01 16:33:36 as
	Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel [My Copy] J Pharmacol Exp Ther, Vol. 301, No. 2. (1 May 2002), pp. 427-434. by Sean Ekins, William J. Crumb, Dustan R. Sarazan, James H. Wikel, Steven A. Wrighton posted to herg by superpyrin on 2008-04-01 16:31:02 as
	HERG Channel (Dys)function Revealed by Dynamic Action Potential Clamp Technique [My Copy] Biophys. J., Vol. 88, No. 1. (1 January 2005), pp. 566-578. by Geza Berecki, Jan G. Zegers, Arie O. Verkerk, et al.Zahurul A. Bhuiyan, Berend de Jonge, Marieke W. Veldkamp, Ronald Wilders, Antoni C. van Ginneken posted to herg myocytes simulation by petergun6666 on 2008-01-24 23:32:08 as
	Pathways of HERG inactivation [My Copy] Am J Physiol Heart Circ Physiol, Vol. 277, No. 1. (1 July 1999), pp. H199-210. by Johann Kiehn, Antonio E. Lacerda, Arthur M. Brown posted to herg by tomb on 2007-09-12 16:10:42 as
	Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique [My Copy] The Journal of Physiology, Vol. 570, No. 2. (January 2006), pp. 237-250. by Geza Berecki, Jan G. Zegers, Zahurul A. Bhuiyan, Arie O. Verkerk, Ronald Wilders, Antoni C. van Ginneken posted to herg by tomb on 2007-09-12 16:09:59 as along with 1 person petergun6666
	Drug block of the hERG potassium channel: Insight from modeling. [My Copy] Proteins, Vol. 68, No. 2. (19 April 2007), pp. 568-580. by Phillip J J. Stansfeld, Peter Gedeck, Martin Gosling, Brian Cox, John S S. Mitcheson, Michael J J. Sutcliffe posted to channel herg by dimka on 2007-09-06 20:08:24 as along with 1 person superpyrin
	QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development. [My Copy] Med Res Rev, Vol. 25, No. 2. (March 2005), pp. 133-166. by M. Recanatini, E. Poluzzi, M. Masetti, A. Cavalli, F. De Ponti posted to herg by superpyrin on 2007-07-01 11:19:17 as
	hERG potassium channels and cardiac arrhythmia [My Copy] Nature, Vol. 440, No. 7083. (22 March 2006), pp. 463-469. by Michael C. Sanguinetti, Martin Tristani-Firouzi posted to herg by superpyrin on 2007-07-01 09:17:57 as along with 1 person tomb
	A Family of Potassium Channel Genes Related to eag in Drosophila and Mammals [My Copy] PNAS, Vol. 91, No. 8. (12 April 1994), pp. 3438-3442. by Jw Warmke, B. Ganetzky posted to herg by superpyrin on 2007-07-01 08:52:12 as
	A two-state homology model of the hERG K+ channel: application to ligand binding. [My Copy] Bioorg Med Chem Lett, Vol. 15, No. 6. (15 March 2005), pp. 1737-1741. by R. Rajamani, B. A. Tounge, J. Li, C. H. Reynolds posted to herg by superpyrin on 2007-06-04 14:40:22 as
	Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods. [My Copy] FEBS Lett, Vol. 579, No. 13. (23 May 2005), pp. 2939-2944. by F. Osterberg, J. Aqvist posted to herg by superpyrin on 2007-06-04 14:38:46 as
	A novel structure-based virtual screening model for the hERG channel blockers. [My Copy] Biochem Biophys Res Commun, Vol. 355, No. 4. (20 April 2007), pp. 889-894. by L. Du, M. Li, Q. You, L. Xia posted to herg by superpyrin on 2007-06-04 14:38:07 as
	A novel hypothesis for the binding mode of HERG channel blockers. [My Copy] Biochem Biophys Res Commun, Vol. 344, No. 1. (26 May 2006), pp. 72-78. by H. Choe, K. H. Nah, S. N. Lee, et al.H. S. Lee, H. S. Lee, S. H. Jo, C. H. Leem, Y. J. Jang posted to herg by superpyrin on 2007-06-04 14:19:08 as
	Determination of hERG channel blockers using a decision tree. [My Copy] Bioorg Med Chem, Vol. 14, No. 15. (1 August 2006), pp. 5325-5332. by M. M. Gepp, M. C. Hutter posted to herg by superpyrin on 2007-06-04 14:17:26 as
	A QSAR model of HERG binding using a large, diverse, and internally consistent training set. [My Copy] Chem Biol Drug Des, Vol. 67, No. 4. (April 2006), pp. 284-296. by M. Seierstad, D. K. Agrafiotis posted to herg by superpyrin on 2007-06-04 14:14:10 as
	An Accurate and Interpretable Bayesian Classification Model for Prediction of hERG Liability [My Copy] ChemMedChem, Vol. 1, No. 3. (2006), pp. 315-322. by Hongmao Sun posted to herg by superpyrin on 2007-06-04 14:06:13 as
	In Silico Classification of hERG Channel Blockers: a Knowledge-Based Strategy [My Copy] ChemMedChem, Vol. 1, No. 6. (2006), pp. 622-630. by Elodie Dubus, Ismaïl Ijjaali, François Petitet, André Michel posted to herg by superpyrin on 2007-06-04 14:01:43 as along with 1 person ucbcjbm
	Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers. [My Copy] J Med Chem, Vol. 49, No. 23. (16 November 2006), pp. 6917-6921. by A. M. Aronov posted to herg by superpyrin on 2007-06-04 13:54:43 as
	HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function. [My Copy] J Biol Chem, Vol. 282, No. 8. (23 February 2007), pp. 5506-5513. by T. Nakajima, K. Hayashi, P. C. Viswanathan, et al.M. Y. Kim, M. Anghelescu, K. A. Barksdale, W. Shuai, J. R. Balser, S. Kupershmidt posted to herg by superpyrin on 2007-06-04 13:54:23 as
	A quantitative assessment of hERG liability as a function of lipophilicity [My Copy] Bioorganic & Medicinal Chemistry Letters, Vol. 17, No. 6. (15 March 2007), pp. 1759-1764. by Michael J. Waring, Craig Johnstone posted to herg lipophilicity by superpyrin on 2007-06-04 13:42:22 as along with 1 person daevans
	Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel. [My Copy] J Phys Chem B, Vol. 111, No. 5. (8 February 2007), pp. 1090-1098. by R. Kutteh, J. I. Vandenberg, S. Kuyucak posted to herg by superpyrin on 2007-06-04 13:32:15 as
	Modulation of HERG Gating by a Charge Cluster in the N-Terminal Proximal Domain [My Copy] Biophys. J., Vol. 91, No. 12. (15 December 2006), pp. 4381-4391. by J. B. Saenen, A. J. Labro, A. Raes, D. J. Snyders posted to herg by superpyrin on 2007-06-04 12:57:57 as
	Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs [My Copy] Mol Pharmacol, Vol. 69, No. 2. (1 February 2006), pp. 509-519. by Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, et al.Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe, John S. Mitcheson posted to herg by superpyrin on 2007-06-04 12:55:38 as
	Molecular Determinants of hERG Channel Block [My Copy] Mol Pharmacol, Vol. 69, No. 5. (1 May 2006), pp. 1709-1716. by Kaichiro Kamiya, Ryoko Niwa, John S. Mitcheson, Michael C. Sanguinetti posted to herg by superpyrin on 2007-06-04 12:48:30 as
	A model for human ventricular tissue. [My Copy] Am J Physiol Heart Circ Physiol, Vol. 286, No. 4. (April 2004) by Ten K. H. Tusscher, D. Noble, P. J. Noble, A. V. Panfilov posted to model human herg by tomb on 2007-02-12 07:29:19 as along with 3 people vgurev petergun6666 rsimitev
	Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. [My Copy] J Gen Physiol, Vol. 115, No. 3. (March 2000), pp. 229-240. by J. S. Mitcheson, J. Chen, M. C. Sanguinetti posted to trap herg drug by tomb on 2007-02-12 07:25:06 as
	Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. [My Copy] Circ Res, Vol. 89, No. 1. (6 July 2001), pp. 33-38. by R. Mazhari, J. L. Greenstein, R. L. Winslow, E. Marbán, H. B. Nuss posted to model herg by tomb on 2007-02-12 07:20:43 as
	Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. [My Copy] Cardiovasc Res, Vol. 50, No. 2. (May 2001), pp. 301-313. by C. E. Clancy, Y. Rudy posted to model herg by tomb on 2007-02-12 07:15:46 as along with 1 person thegoose
	Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern. [My Copy] J Pharmacol Toxicol Methods, Vol. 50, No. 2. (t 2004), pp. 93-101. by G. E. Kirsch, E. S. Trepakova, J. C. Brimecombe, et al.S. S. Sidach, H. D. Erickson, M. C. Kochan, L. M. Shyjka, A. E. Lacerda, A. M. Brown posted to sotalol herg hek by tomb on 2007-02-11 13:22:45 as
	Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. [My Copy] Biophys J, Vol. 74, No. 1. (January 1998), pp. 230-241. by Z. Zhou, Q. Gong, B. Ye, et al.Z. Fan, J. C. Makielski, G. A. Robertson, C. T. January posted to herg hek by tomb on 2007-02-10 16:49:27 as
	Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. [My Copy] Circulation, Vol. 94, No. 10. (15 November 1996), pp. 2572-2579. by J. Kiehn, A. E. Lacerda, B. Wible, A. M. Brown posted to kinetics herg by tomb on 2007-02-10 10:12:12 as
	Predicting undesirable drug interactions with promiscuous proteins in silico [My Copy] Drug Discovery Today, Vol. 9, No. 6. (15 March 2004), pp. 276-285. by S. Ekins posted to model inhibition herg by tomb on 2007-02-10 09:17:14 as along with 4 people pablocarb pauldobson kuhn girschick
	Development and Evaluation of an in Silico Model for hERG Binding [My Copy] Journal of Chemical Information and Modeling, Vol. 46, No. 1. (1 January 2006), pp. 392-400. by Minghu Song, Matthew Clark posted to model inhibition herg by tomb on 2007-02-10 09:05:58 as along with 1 person ucbcjbm
	A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. [My Copy] Cell, Vol. 80, No. 5. (10 March 1995), pp. 795-803. by M. E. Curran, I. Splawski, K. W. Timothy, G. M. Vincent, E. D. Green, M. T. Keating posted to lqts herg by tomb on 2007-02-10 09:03:17 as
	Insights for human ether-a-go-go-related gene potassium channel inhibition using recursive partitioning and Kohonen and Sammon mapping techniques. [My Copy] J Med Chem, Vol. 49, No. 17. (24 August 2006), pp. 5059-5071. by S. Ekins, K. V. Balakin, N. Savchuk, Y. Ivanenkov posted to inhibition herg by tomb on 2007-02-10 08:49:14 as
	Effects of premature stimulation on HERG K(+) channels. [My Copy] J Physiol, Vol. 537, No. Pt 3. (15 December 2001), pp. 843-851. by Y. Lu, M. P. Mahaut-Smith, A. Varghese, C. L. Huang, P. R. Kemp, J. I. Vandenberg posted to model herg by tomb on 2007-02-07 21:58:54 as
	Mathematical model of the rapidly activating delayed rectifier potassium current I(Kr) in rabbit sinoatrial node. [My Copy] J Cardiovasc Electrophysiol, Vol. 13, No. 11. (November 2002), pp. 1131-1140. by C. S. Oehmen, W. R. Giles, S. S. Demir posted to model herg by tomb on 2007-02-07 21:57:46 as
	State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytes. [My Copy] J Physiol, Vol. 526 Pt 2 (15 July 2000), pp. 265-278. by M. Weerapura, S. Nattel, M. Courtemanche, D. Doern, N. Ethier, T. Hebert posted to inhibition herg drug by tomb on 2007-02-07 21:49:11 as
	A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. [My Copy] J Physiol, Vol. 502 ( Pt 1) (1 July 1997), pp. 45-60. by S. Wang, S. Liu, M. J. Morales, H. C. Strauss, R. L. Rasmusson posted to physiology herg by tomb on 2007-01-30 22:26:19 as

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