Tag mdm2 [52 articles] Export

Recent papers classified by the tag mdm2.

	Structural biology of the p53 tumour suppressor [My Copy] Current Opinion in Structural Biology, Vol. 19, No. 2. (13 April 2009), pp. 197-202. by Andrei L. Okorokov, Elena V. Orlova posted to p53 mdm2 by ubcg08l on 2009-08-24 16:37:45 as along with 2 people guhjy paulschlesinger
	Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. [My Copy] ChemMedChem, Vol. 3, No. 7. (July 2008), pp. 1118-1128. by Ulli Rothweiler, Anna Czarna, Marcin Krajewski, et al.Jolanta Ciombor, Cédric Kalinski, Vladimir Khazak, Günther Ross, Natalia Skobeleva, Lutz Weber, Tad A. Holak posted to protein-protein mdm2 by ubcg08l on 2009-08-24 16:18:41 as
	Structural Biology of the Tumor Suppressor p53 [My Copy] Annual Review of Biochemistry, Vol. 77, No. 1. (2008), pp. 557-582. by Andreas C. Joerger, Alan R. Fersht posted to protein-protein mdm2 by ubcg08l on 2009-08-24 16:06:24 as along with 2 people BNodes guhjy
	Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes. [My Copy] The Journal of biological chemistry, Vol. 284, No. 13. (27 March 2009), pp. 8812-8821. by Joerg Kallen, Arnaud Goepfert, Anke Blechschmidt, et al.Aude Izaac, Martin Geiser, Gisele Tavares, Paul Ramage, Pascal Furet, Keiichi Masuya, Joanna Lisztwan posted to protein-protein mdm2 by ubcg08l on 2009-08-24 15:58:37 as
	Design of protein-protein interaction inhibitors based on protein epitope mimetics. [My Copy] Chembiochem : a European journal of chemical biology, Vol. 10, No. 6. (17 April 2009), pp. 971-973. by John A. Robinson posted to protein-protein mdm2 by ubcg08l on 2009-08-24 15:57:45 as
	The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction. [My Copy] Natural product reports, Vol. 26, No. 4. (April 2009), pp. 465-477. by Ryan C. Clark, Sang Yeul Y. Lee, Mark Searcey, Dale L. Boger posted to 2009 mdm2 np p53 ppi xf by higueruelo on 2009-08-03 15:57:31 as
	In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 [My Copy] Science, Vol. 303, No. 5659. (06 February 2004), pp. 844-848. by L. T. Vassilev posted to mdm2 p53 by ubcg08l on 2009-07-23 14:18:49 as along with 3 people girayenkavi sbiring Evangelia
	Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists. [My Copy] Journal of combinatorial chemistry (23 June 2009) by Stuti Srivastava, Barbara Beck, Wei Wang, Anna Czarna, Tad A. Holak, Alexander Dömling posted to 2009 mdm2 ppi sm xf by higueruelo on 2009-06-29 14:11:50 as
	Recent Advances in Validating MDM2 as a Cancer Target. [My Copy] Anti-cancer agents in medicinal chemistry (1 September 2009) by Elizabeth R. Rayburn, Scharri J. Ezell, Ruiwen Zhang posted to 2009 mdm2 ppi review by higueruelo on 2009-06-29 14:05:20 as
	Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene [My Copy] Proceedings of the National Academy of Sciences (4 June 2009) by Gurinder S. Atwal, Kirchhoff, Elisabeth E. Bond, et al.Marco Monagna, Chiara Menin, Roberta Bertorelle, Maria C. Scaini, Frank Bartel, Anja Böhnke, Christina Pempe, Elise Gradhand, Steffen Hauptmann, Kenneth Offit, Arnold J. Levine, Gareth L. Bond posted to ovarian-cancer genome-wide-association breast-cancer mdm2 mdm4 p53 snp tp53 by frohike on 2009-06-05 16:36:46 as
	HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. [My Copy] Nature cell biology, Vol. 3, No. 11. (November 2001), pp. 973-982. by B. P. Zhou, Y. Liao, W. Xia, Y. Zou, B. Spohn, M. C. Hung posted to akt dna-damage her-2 mdm2 p53 by bloomekj on 2009-05-30 05:24:24 as
	Critical role for Daxx in regulating Mdm2 [My Copy] Nature Cell Biology, Vol. 8, No. 8. (16 July 2006), pp. 855-862. by Jun Tang, Li-Ke Qu, Jianke Zhang, et al.Wenge Wang, Jennifer S. Michaelson, Yan Y. Degenhardt, Wafik S. El-Deiry, Xiaolu Yang posted to damage daxx dna mdm2 p53 by agrawalt on 2009-05-06 20:02:02 as
	Do MDM2 SNP309 and TP53 R72P Interact in Breast Cancer Susceptibility? A Large Pooled Series from the Breast Cancer Association Consortium. [My Copy] Cancer Res, Vol. 67, No. 19. (1 October 2007), pp. 9584-9590. by M. K. Schmidt, S. Reincke, A. Broeks, et al.L. M. Braaf, F. B. Hogervorst, R. A. Tollenaar, N. Johnson, O. Fletcher, J. Peto, J. Tommiska, C. Blomqvist, H. A. Nevanlinna, C. S. Healey, A. M. Dunning, P. D. Pharoah, D. F. Easton, T. Dörk, L. J. Van't Veer, posted to breast cancer mdm2 p53 polymorphism wchs by songpku on 2009-04-07 18:36:31 as along with 1 person Terkko
	Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53MDM2 signaling pathway [My Copy] Oncogene, Vol. aop, No. current. by C. S. Busso, T. Iwakuma, T. Izumi posted to ape1 cancer damage mdm2 p53 by DevilInPgh on 2009-04-02 20:04:43 as
	Study of MDM2 Binding to p53-Analogues: Affinity, Helicity, and Applicability to Drug Design. [My Copy] Journal of chemical information and modeling (26 March 2009) by Ori Kalid, Nir Ben-Tal posted to 2009 flexibility mdm2 p53 peptidomimetics ppi by higueruelo on 2009-04-01 08:49:27 as
	Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. [My Copy] Cancer research, Vol. 53, No. 22. (15 November 1993), pp. 5535-5541. by Z. A. Khatib, H. Matsushime, M. Valentine, D. N. Shapiro, C. J. Sherr, A. T. Look posted to amplification cancer cdk4 gli mdm2 sarcoma by catcremona on 2009-01-26 17:22:06 as
	Amplification of CDK4 and MDM2 in malignant melanoma. [My Copy] Genes, chromosomes & cancer, Vol. 45, No. 5. (May 2006), pp. 447-454. by V. Muthusamy, C. Hobbs, C. Nogueira, et al.C. Cordon-Cardo, P. H. McKee, L. Chin, M. W. Bosenberg posted to cancer cdk4 mdm2 melanoma by catcremona on 2009-01-04 14:49:41 as
	Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer. [My Copy] Expert opinion on investigational drugs, Vol. 17, No. 12. (December 2008), pp. 1865-1882. by S. Patel, M. R. Player posted to 2008 mdm2 p53 ppi review sm xf by higueruelo on 2008-11-19 13:36:03 as
	Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. [My Copy] Annual review of pharmacology and toxicology (3 October 2008) by Sanjeev Shangary, Shaomeng Wang posted to 2008 mdm2 p53 ppi review sm xf by higueruelo on 2008-10-07 23:36:18 as along with 1 person guhjy
	Small Molecule Inhibitors of the p53-MDM2. [My Copy] Current medicinal chemistry, Vol. 15, No. 17. (2008), pp. 1720-1730. by C. Q. Hu, Y. Z. Hu posted to 2008 mdm2 p53 ppi review sm xf by higueruelo on 2008-09-10 16:16:22 as
	Targeting the MDM2-p53 Interaction for Cancer Therapy. [My Copy] Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, No. 17. (1 September 2008), pp. 5318-5324. by S. Shangary, S. Wang posted to 2008 mdm2 p53 ppi review sm xf by higueruelo on 2008-09-04 16:18:00 as along with 1 person guhjy
	Mdm2 promotes genetic instability and transformation independent of p53. [My Copy] Molecular and cellular biology, Vol. 28, No. 15. (1 August 2008), pp. 4862-4874. by A. Bouska, T. Lushnikova, S. Plaza, C. M. Eischen posted to cancer dna-damage journalclub mdm2 by mapplab on 2008-08-07 19:56:52 as along with 1 person danaiancu
	The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. [My Copy] Cancer cell, Vol. 12, No. 4. (October 2007), pp. 342-354. by X. Lu, O. Ma, T. A. Nguyen, S. N. Jones, M. Oren, L. A. Donehower posted to mdm2 p53 by tibbitts on 2008-07-31 20:46:35 as
	Small molecular weight protein-protein interaction antagonists--an insurmountable challenge? [My Copy] Current Opinion in Chemical Biology, Vol. 12, No. 3. (June 2008), pp. 281-291. by Alexander Dömling posted to 2008 mdm2 p53 ppi sm xf by higueruelo on 2008-07-17 10:06:39 as
	Computational studies and peptidomimetic design for the human p53-MDM2 complex. [My Copy] Proteins, Vol. 58, No. 1. (1 January 2005), pp. 222-234. by H. Zhong, H. A. Carlson posted to 2005 mdm2 p53 peptidomimetics ppi by higueruelo on 2008-07-07 11:52:28 as along with 1 person blackbart
	Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction. [My Copy] Angewandte Chemie (International ed. in English), Vol. 43, No. 16. (13 April 2004), pp. 2109-2112. by R. Fasan, R. L. Dias, K. Moehle, et al.O. Zerbe, J. W. Vrijbloed, D. Obrecht, J. A. Robinson posted to 2004 betaturn mdm2 p53 peptidomimetics sm xf by higueruelo on 2008-07-01 16:50:05 as
	Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft. [My Copy] Journal of the American Chemical Society, Vol. 130, No. 20. (21 May 2008), pp. 6472-6478. by S. A. Showalter, L. Bruschweiler-Li, E. Johnson, F. Zhang, R. Brüschweiler posted to 2008 complex dynamics flexibility mdm2 p53 ppi sm by higueruelo on 2008-06-24 19:48:58 as
	Hdmx Stabilizes Mdm2 and p53 [My Copy] J. Biol. Chem., Vol. 275, No. 36. (1 September 2000), pp. 28039-28044. by Robert Stad, Yolande F. Ramos, Natalie Little, et al.Shula Grivell, Joline Attema, Alex J. van der Eb, Aart G. Jochemsen posted to mdm2 mdmx p53 by Ichiro_a on 2008-06-20 11:04:45 as
	Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein [My Copy] J. Biol. Chem., Vol. 274, No. 53. (31 December 1999), pp. 38189-38196. by Darcie A. Sharp, Stephen A. Kratowicz, Michael J. Sank, Donna L. George posted to mdm2 mdmx p53 by Ichiro_a on 2008-06-20 10:57:39 as
	A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage. [My Copy] Biochemical pharmacology, Vol. 75, No. 9. (1 May 2008), pp. 1743-1750. by K. Ishi, F. Sugawara posted to 2008 mdm2 p53 phage ppi sm xf by higueruelo on 2008-04-22 10:33:08 as
	BCR/ABL activates mdm2 mRNA translation via the La antigen [My Copy] Cancer Cell, Vol. 3, No. 2. (February 2003), pp. 145-160. by Rossana Trotta, Tatiana Vignudelli, Olivia Candini, et al.Robert V. Intine, Luisa Pecorari, Clara Guerzoni, Giorgia Santilli, Mike W. Byrom, Silvia Goldoni, Lance P. Ford, Michael A. Caligiuri, Richard J. Maraia, Danilo Perrotti, Bruno Calabretta posted to la mdm2 mrna translation by jonathanjacobs to the group The La Autoantigen. on 2008-03-31 19:49:31 as
	Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. [My Copy] Proc Natl Acad Sci U S A, Vol. 96, No. 24. (23 November 1999), pp. 13777-13782. by N. H. Chehab, A. Malikzay, E. S. Stavridi, T. D. Halazonetis posted to atm atr chk1 chk2 mdm2 p53 by DNAReplication on 2008-02-03 20:41:46 as along with 1 person catcremona
	Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. [My Copy] J Med Chem, Vol. 49, No. 13. (29 June 2006), pp. 3759-3762. by Y. Lu, Z. Nikolovska-Coleska, X. Fang, et al.W. Gao, S. Shangary, S. Qiu, D. Qin, S. Wang posted to 2006 mdm2 p53 ppi sm xf by higueruelo on 2008-01-28 12:00:04 as along with 2 people blackbart pkolb
	AKT signaling promotes derivation of embryonic germ cells from primordial germ cells. [My Copy] Development (23 January 2008) by Tohru Kimura, Maya Tomooka, Noriko Yamano, et al.Kazushige Murayama, Shogo Matoba, Hiroki Umehara, Yoshiakira Kanai, Toru Nakano posted to akt gsk3 mdm2 p53 pgc pi3k by sebastien_vigneau on 2008-01-27 12:34:43 as
	Development of E3-substrate (MDM2-p53)-binding inhibitors: structural aspects. [My Copy] Methods Enzymol, Vol. 399 (2005), pp. 622-633. by D. C. Fry, B. Graves, L. T. Vassilev posted to 2005 mdm2 p53 ppi review sm xf by higueruelo on 2007-12-01 19:57:59 as
	Small Molecule Protein-Protein Inhibitors for the p53-MDM2 Interaction [My Copy] pp. 952-960. by Anna S. Dudkina, Craig W. Lindsley posted to 2007 ctmc7 mdm2 p53 ppi review sm xf by higueruelo on 2007-12-01 17:25:42 as
	Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. [My Copy] J Med Chem, Vol. 49, No. 12. (15 June 2006), pp. 3432-3435. by K. Ding, Y. Lu, Z. Nikolovska-Coleska, et al.G. Wang, S. Qiu, S. Shangary, W. Gao, D. Qin, J. Stuckey, K. Krajewski, P. P. Roller, S. Wang posted to 2006 mdm2 p53 ppi sm xf by higueruelo on 2007-12-01 15:15:05 as along with 1 person blackbart
	NMR structure of a complex between MDM2 and a small molecule inhibitor [My Copy] Journal of Biomolecular NMR, Vol. 30, No. 2., 163. by David C. Fry, S. Donald Emerson, Stefan Palme, Binh T. Vu, Chao-Min Liu, Frank Podlaski posted to 2004 mdm2 nmr p53 ppi roche sm xf by higueruelo on 2007-12-01 15:13:11 as
	Small Molecule Inhibitors of the MDM2-p53 Interaction Discovered by Ensemble-Based Receptor Models [My Copy] J. Am. Chem. Soc., Vol. 129, No. 42. (24 October 2007), pp. 12809-12814. by A. L. Bowman, Z. Nikolovska-Coleska, H. Zhong, S. Wang, H. A. Carlson posted to 2007 flexibility mdm2 p53 ppi sm vs xf by higueruelo on 2007-12-01 15:07:18 as
	The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP [My Copy] Oncogene, Vol. aop, No. current. by C. L. Brooks, M. Li, M. Hu, Y. Shi, W. Gu posted to 2007 complex hausp mdm2 p53 ppi by higueruelo on 2007-12-01 15:02:41 as along with 1 person Dualsystems
	Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53HDM2 ProteinProtein Interaction [My Copy] International Journal of Peptide Research and Therapeutics, Vol. 12, No. 1. (March 2006), pp. 3-19. by Peter M. Fischer posted to 2006 intimbal mdm2 p53 peptidomimetics ppi review sm by higueruelo on 2007-11-26 17:02:12 as
	Targeting protein-protein interactions: Lessons from p53/MDM2. [My Copy] Biopolymers, Vol. 88, No. 5. (10 April 2007), pp. 657-686. by Justin K K. Murray, Samuel H H. Gellman posted to 2007 intimbal mdm2 p53 ppi review sm by higueruelo on 2007-11-26 16:48:04 as along with 2 people guhjy yeastyboy
	Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. [My Copy] Cancer Res, Vol. 67, No. 15. (1 August 2007), pp. 7350-7357. by A. Efeyan, A. Ortega-Molina, S. Velasco-Miguel, D. Herranz, L. T. Vassilev, M. Serrano posted to interaction mdm2 molecule nutlin p53 small by yeastyboy on 2007-09-11 12:25:28 as
	HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function [My Copy] Oncogene, Vol. aop, No. current. by L. M. S. Lau, J. K. Nugent, X. Zhao, M. S. Irwin posted to interaction mdm2 molecule nutlin p53 small by yeastyboy on 2007-09-11 12:21:23 as
	Nutlin-3 inhibits the NFkappaB Pathway in a p53 Dependent Manner: Implications in Lung Cancer Therapy. [My Copy] Cell Cycle, Vol. 6, No. 17. (27 June 2007) by Anwesha Dey, E T T. Wong, P Bist, V Tergaonkar, David P. Lane posted to interaction mdm2 nutlin p53 by yeastyboy on 2007-09-11 12:18:27 as
	A simple cell-based HTS assay system to screen for inhibitors of p53-Hdm2 protein-protein interactions. [My Copy] Assay Drug Dev Technol, Vol. 4, No. 6. (December 2006), pp. 679-688. by B. K. Lundholt, A. Heydorn, S. P. Bjørn, M. Praestegaard posted to hts mdm2 p52 screening by yeastyboy on 2007-09-10 18:27:18 as along with 1 person guhjy
	The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis-inducing stimuli. [My Copy] J Pathol, Vol. 200, No. 2. (June 2003), pp. 137-148. by D. C. Spierings, E. G. de Vries, E. Vellenga, S. de Jong posted to apoptosis cisplatin male_germ_line mdm2 p53 testis tumour by uz_labu_laimi on 2007-08-28 16:02:53 as along with 1 person daed
	Ribosomal protein S7 as a novel modulator of p53\|[ndash]\|MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function [My Copy] Oncogene, Vol. aop, No. current. by D. Chen, Z. Zhang, M. Li, et al.W. Wang, Y. Li, E. R. Rayburn, D. L. Hill, H. Wang, R. Zhang posted to mdm2 p53 rps7 by sbranco on 2007-08-02 16:08:33 as
	The p53-binding Protein MDM2 Gene Is Differentially Expressed in Human Breast Carcinoma [My Copy] Cancer Res, Vol. 53, No. 14. (15 July 1993), pp. 3226-3228. by Saeed M. Sheikh, Zhi-Ming Shao, Arif Hussain, Joseph A. Fontana posted to p53 mdm2 mda-mb-231 cancer breast by meledeo to the group YaremaLab on 2007-07-18 19:58:57 as
	L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes. [My Copy] Cell Cycle, Vol. 5, No. 15. (1 August 2006) by Damon Banks, Min Wu, Leigh Ann A. Higa, et al.Nadia Gavrilova, Junmin Quan, Tao Ye, Ryuji Kobayashi, Hong Sun, Hui Zhang posted to cdt2 cul4 ddb1 dtl mdm2 p53 by DNAReplication on 2006-07-27 14:16:40 as

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p53	49
ppi	21
sm	17
xf	15
review	10
cancer	8
protein-protein	8
2008	7
2007	4
2009	4
interaction	4
peptidomimetics	4
2006	3
akt	3
breast	3
dna-damage	3
flexibility	3
mdmx	3
molecule	3
nutlin	3
small	3
2004	2
2005	2
atm	2
atr	2
cdk4	2
chk1	2
chk2	2
complex	2
damage	2
intimbal	2
journalclub	2
la	2
mda-mb-231	2
mrna	2
translation	2
amplification	1
ape1	1
apoptosis	1
betaturn	1
breast-cancer	1
cdt2	1
cisplatin	1
conformational_transitions	1
ctmc7	1
cul4	1
daxx	1
ddb1	1
dna	1
dtl	1
dynamics	1
genome-wide-association	1
gli	1
gsk3	1
hausp	1
hdm2	1
her-2	1
hts	1
male_germ_line	1
mdm4	1
melanoma	1
nmr	1
np	1
oct09	1
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p14arf	1
p52	1
pdb	1
pgc	1
phage	1
phosphorylation	1
pi3k	1
polymorphism	1
protein	1
roche	1
rps7	1
sarcoma	1
screening	1
snp	1
testis	1
tp53	1
tumour	1
vs	1
wchs	1
x-ray	1

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