Tag parp [190 articles] Export

Recent papers classified by the tag parp.

	Poly(Adp-Ribose) Polymerase (Parp) Inhibition Counteracts Multiple Manifestations Of Kidney Disease In Long-Term Streptozotocin-Diabetic Rat Model. [My Copy] Biochemical pharmacology (26 November 2009) by Hanna Shevalye, Roman Stavniichuk, Weizheng Xu, et al.Jie Zhang, Sergey Lupachyk, Yury Maksimchyk, Viktor R. Drel, Elizabeth Z. Floyd, Barbara Slusher, Irina G. Obrosova posted to stz rat parp dn by guhjy on 2009-12-02 06:55:10 as
	Poly(Adenosine 5'-Diphosphate-Ribose) Polymerase Inhibition Counteracts Multiple Manifestations of Experimental Type 1 Diabetic Nephropathy [My Copy] Endocrinology, Vol. 150, No. 12. (1 December 2009), pp. 5273-5283. by Viktor R. Drel, Weizheng Xu, Jie Zhang, et al.Ivan A. Pavlov, Hanna Shevalye, Barbara Slusher, Irina G. Obrosova posted to tgfb stz ros rat parp dn by guhjy on 2009-11-02 02:21:21 as
	Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair [My Copy] Clinical Cancer Research, Vol. 15, No. 20. (15 October 2009), pp. 6314-6320. by Emma Bolderson, Derek J. Richard, Bin-Bing S. Zhou, Kum K. Khanna posted to parp dna_repair by merpublic on 2009-11-01 09:25:40 as
	A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. [My Copy] Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 26, No. 22. (1 August 2008), pp. 3785-3790. by Alan Ashworth posted to parp oct_30 brca1_and_brca2 by aeisen on 2009-10-30 04:59:48 as along with 1 person catcremona
	Synthetic lethality--a new direction in cancer-drug development. [My Copy] The New England journal of medicine, Vol. 361, No. 2. (9 July 2009), pp. 189-191. by J. Dirk Iglehart, Daniel P. Silver posted to parp oct30 brca1_and_brca2 by aeisen on 2009-10-27 03:25:31 as
	Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. [My Copy] The New England journal of medicine, Vol. 361, No. 2. (9 July 2009), pp. 123-134. by Peter C. Fong, David S. Boss, Timothy A. Yap, et al.Andrew Tutt, Peijun Wu, Marja Mergui-Roelvink, Peter Mortimer, Helen Swaisland, Alan Lau, Mark J. O'Connor, Alan Ashworth, James Carmichael, Stan B. Kaye, Jan H. Schellens, Johann S. de Bono posted to parp oct30 brca1_and_brca2 by aeisen on 2009-10-27 03:24:27 as along with 1 person frohike
	Targeting the molecular defect in BRCA-deficient tumors for cancer therapy. [My Copy] Cancer cell, Vol. 16, No. 2. (4 August 2009), pp. 89-90. by Ashok R. Venkitaraman posted to parp oct30 brca1_and_brca2 by aeisen on 2009-10-27 03:23:38 as
	Phase II trial of the oral PARP inhibitor olaparib (AZD2281) in BRCA-deficient advanced ovarian cancer [My Copy] J Clin Oncol (Meeting Abstracts), Vol. 27, No. 15S. (20 May 2009), 5500. by M. W. Audeh, R. T. Penson, M. Friedlander, et al.B. Powell, K. M. Bell-McGuinn, C. Scott, J. N. Weitzel, J. Carmichael, A. Tutt posted to parp ovarian olaparib brca2 brca1 by merpublic on 2009-10-05 21:28:25 as
	Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer [My Copy] J Clin Oncol (Meeting Abstracts), Vol. 27, No. 18S. (20 June 2009), CRA501. by A. Tutt, M. Robson, J. E. Garber, et al.S. Domchek, M. W. Audeh, J. N. Weitzel, M. Friedlander, J. Carmichael posted to parp olaparib brca2 brca1 by merpublic on 2009-10-05 21:24:16 as
	Cisplatin: mode of cytotoxic action and molecular basis of resistance [My Copy] Oncogene, Vol. 22, No. 47. (20 October 2003), pp. 7265-7279. by Zahid H. Siddik posted to platinum parp by merpublic on 2009-10-05 20:40:55 as along with 1 person baikanamako
	Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation [My Copy] Current Opinion in Cell Biology, Vol. 20, No. 3. (June 2008), pp. 294-302. by W. Kraus posted to parp by merpublic on 2009-10-05 16:41:39 as
	Toward specific functions of poly(ADP-ribose) polymerase-2 [My Copy] Trends in Molecular Medicine, Vol. 14, No. 4. (April 2008), pp. 169-178. by J. Yelamos, V. Schreiber, F. Dantzer posted to parp by merpublic on 2009-10-05 16:38:18 as
	Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors [My Copy] Nat Rev Drug Discov, Vol. 4, No. 5. (01 May 2005), pp. 421-440. by Prakash Jagtap, Csaba Szabo posted to parp by merpublic on 2009-10-05 16:29:26 as
	Poly(ADP-ribose): novel functions for an old molecule [My Copy] Nat Rev Mol Cell Biol, Vol. 7, No. 7. (01 July 2006), pp. 517-528. by Valerie Schreiber, Francoise Dantzer, Jean-Christophe Ame, Gilbert de Murcia posted to parp by merpublic on 2009-10-05 16:27:34 as along with 1 person cannin
	The PARP superfamily [My Copy] BioEssays, Vol. 26, No. 8. (August 2004), pp. 882-893. by Jean-Christophe Amé, Catherine Spenlehauer, Gilbert de Murcia posted to parp by merpublic on 2009-10-05 16:25:29 as along with 2 people yedmonds ieken
	Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial [My Copy] Molecular Cancer Therapeutics, Vol. 6, No. 3. (March 2007), pp. 945-956. by Huw D. Thomas, Christopher R. Calabrese, Michael A. Batey, et al.Stacie Canan, Zdenek Hostomsky, Suzanne Kyle, Karen A. Maegley, David R. Newell, Donald Skalitzky, Lan-Zhen Wang, Stephen E. Webber, Nicola J. Curtin posted to parp by merpublic on 2009-10-05 14:11:09 as
	4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 [My Copy] Journal of Medicinal Chemistry, Vol. 51, No. 20. (23 October 2008), pp. 6581-6591. by Keith A. Menear, Claire Adcock, Robert Boulter, et al.Xiao-ling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh, Ian T. W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C. M. Smith, Niall M. B. Martin posted to parp olaparib by merpublic on 2009-10-05 02:59:27 as
	Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer [My Copy] Journal of Medicinal Chemistry, Vol. 52, No. 2. (22 January 2009), pp. 514-523. by Thomas D. Penning, Gui-Dong Zhu, Viraj B. Gandhi, et al.Jianchun Gong, Xuesong Liu, Yan Shi, Vered Klinghofer, Eric F. Johnson, Cherrie K. Donawho, David J. Frost, Velitchka Bontcheva-Diaz, Jennifer J. Bouska, Donald J. Osterling, Amanda M. Olson, Kennan C. Marsh, Yan Luo, Vincent L. Giranda posted to parp by merpublic on 2009-10-05 02:55:47 as
	PARP inhibitors blaze a trail in difficult-to-treat cancers [My Copy] Nat Biotech, Vol. 27, No. 9. (01 September 2009), pp. 784-786. by Jim Kling posted to parp inhibitor by ericrpaquet on 2009-09-10 16:08:11 as
	A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation [My Copy] Nature Structural & Molecular Biology, Vol. 16, No. 9. (13 August 2009), pp. 923-929. by Gyula Timinszky, Susanne Till, Paul O. Hassa, et al.Michael Hothorn, Georg Kustatscher, Bianca Nijmeijer, Julien Colombelli, Matthias Altmeyer, Ernst H. K. Stelzer, Klaus Scheffzek, Michael O. Hottiger, Andreas G. Ladurner posted to repair parp dna damage chromatin by ericrpaquet on 2009-09-10 15:55:28 as
	Resveratrol protects mitochondria against oxidative stress through AMPK-mediated GSK3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. [My Copy] Molecular pharmacology (20 July 2009) by Sang Mi M. Shin, Il Je J. Cho, Sang Geon G. Kim posted to resveratrol parp lkb gsk ampk by guhjy on 2009-08-23 05:16:45 as along with 1 person and 1 group HEIRS HEIRS - Environmental Illness Research
	Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90 [My Copy] Molecular Cancer Therapeutics, Vol. 8, No. 8. (August 2009), pp. 2243-2254. by Fiona A. Dungey, Keith W. Caldecott, Anthony J. Chalmers posted to repair radiosensitization parp hsp90 glioma dna by ericrpaquet on 2009-08-17 19:29:50 as
	SIRT1/PARP-1 functional interplay. [My Copy] Cell cycle (Georgetown, Tex.), Vol. 8, No. 11. (1 June 2009) by Paolo Sassone-Corsi posted to parp sirt by guhjy on 2009-08-08 06:40:52 as
	SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. [My Copy] Molecular and cellular biology, Vol. 29, No. 15. (August 2009), pp. 4116-4129. by Senthilkumar B. Rajamohan, Vinodkumar B. Pillai, Madhu Gupta, et al.Nagalingam R. Sundaresan, Konstantin G. Birukov, Sadhana Samant, Michael O. Hottiger, Mahesh P. Gupta posted to parp sirt by guhjy on 2009-08-08 06:37:29 as
	Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. [My Copy] The FASEB journal : official publication of the Federation of American Societies for Experimental Biology (21 July 2009) by Simon Messner, David Schuermann, Matthias Altmeyer, et al.Ingrid Kassner, Darja Schmidt, Primo Schär, Stefan Müller, Michael O. Hottiger posted to parp sumo by guhjy on 2009-08-02 00:52:58 as
	The PI3 kinase, p38 SAP kinase, and NF-kappa B signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells [My Copy] Blood, Vol. 96, No. 3. (1 August 2000), pp. 1039-1046. by Kirit M. Ardeshna, Arnold R. Pizzey, Stephen Devereux, Asim Khwaja posted to mapk nfkb parp pi3k by tgrih365 on 2009-07-22 22:46:34 as
	Breaching the boundaries that safeguard against repression. [My Copy] Molecular cell, Vol. 34, No. 4. (14 May 2009), pp. 395-397. by V. K. Tiwari, S. B. Baylin posted to adp-ribose adp-ribosylation ctcf epigenetics nuclear-architecture nuclear-localization nucleus parp by sebastien_vigneau on 2009-06-04 18:32:08 as
	Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly (ADP-ribose) polymerase. [My Copy] Biochemical and biophysical research communications, Vol. 134, No. 1. (14 January 1986), pp. 227-232. by S. J. Berger, D. C. Sudar, N. A. Berger posted to ddr nad parp by cannin on 2009-05-15 07:38:09 as
	Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. [My Copy] Experimental cell research, Vol. 268, No. 1. (1 August 2001), pp. 7-13. by L. Davidovic, M. Vodenicharov, E. B. Affar, G. G. Poirier posted to parg parp by cannin on 2009-05-12 22:35:42 as
	Poly (ADP-ribose) polymerase, nitric oxide and cell death. [My Copy] Trends in pharmacological sciences, Vol. 20, No. 4. (April 1999), pp. 171-181. by A. A. Pieper, A. Verma, J. Zhang, S. H. Snyder posted to parp by cannin on 2009-05-12 22:34:07 as
	Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. [My Copy] Trends Biochem Sci, Vol. 20, No. 10. (October 1995), pp. 405-411. by T. Lindahl, M. S. Satoh, G. G. Poirier, A. Klungland posted to ddr parp by cannin on 2009-05-12 22:22:40 as along with 1 person yedmonds
	Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons [My Copy] NeuroMolecular Medicine by Dong Liu, Robert Gharavi, Michael Pitta, Marc Gleichmann, Mark Mattson posted to nad parp sirt1 by cannin on 2009-05-11 22:21:31 as
	Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells. [My Copy] Biochemical and biophysical research communications, Vol. 338, No. 4. (30 December 2005), pp. 1805-1810. by H. J. Moonen, L. Geraets, A. Vaarhorst, A. Bast, E. F. Wouters, G. J. Hageman posted to nad parp by cannin on 2009-05-11 22:17:59 as
	Cleavage of ATM during radiation-induced apoptosis: caspase-3-like apoptotic protease as a candidate. [My Copy] International journal of radiation biology, Vol. 76, No. 10. (October 2000), pp. 1387-1395. by X. Tong, B. Liu, Y. Dong, Z. Sun posted to atm caspase ddr parp by cannin on 2009-05-11 22:14:25 as
	Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response. [My Copy] Biochemical and biophysical research communications, Vol. 319, No. 2. (25 June 2004), pp. 596-602. by F. Watanabe, H. Fukazawa, M. Masutani, et al.H. Suzuki, H. Teraoka, S. Mizutani, Y. Uehara posted to atm ddr parp by cannin on 2009-05-11 22:10:49 as
	PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. [My Copy] DNA repair, Vol. 3, No. 8-9. (p 2004), pp. 1103-1108. by A. Huber, P. Bai, J. M. de Murcia, G. de Murcia posted to atm ddr parp by cannin on 2009-05-11 22:10:02 as
	Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. [My Copy] Cancer research, Vol. 66, No. 16. (15 August 2006), pp. 8109-8115. by N. McCabe, N. C. Turner, C. J. Lord, et al.K. Kluzek, A. Bialkowska, S. Swift, S. Giavara, M. J. O'Connor, A. N. Tutt, M. Z. Zdzienicka, G. C. Smith, A. Ashworth posted to atm chk2 ddr nbs1 parp by cannin on 2009-05-11 22:09:00 as
	Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair [My Copy] Nucleic Acids Research, Vol. 34, No. 6. (2006), pp. 1685-1691. by Helen E. Bryant, Thomas Helleday posted to atm ddr parp by cannin on 2009-05-11 22:05:41 as along with 1 person DNAReplication
	DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment [My Copy] World Journal of Surgery by Yulong Liang, Shiaw-Yih Lin, F. Brunicardi, John Goss, Kaiyi Li posted to atm ddr parp by cannin on 2009-05-11 22:00:52 as
	PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. [My Copy] Molecular cancer therapeutics, Vol. 8, No. 1. (January 2009), pp. 135-140. by J. Mi, E. Bolesta, D. L. Brautigan, J. M. Larner posted to p53 parp pp2a by cannin on 2009-05-11 21:59:34 as
	Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications. [My Copy] Canadian journal of physiology and pharmacology, Vol. 86, No. 6. (June 2008), pp. 365-372. by J. Chiu, B. Y. Xu, S. Chen, B. Feng, S. Chakrabarti posted to dm et parp ros by guhjy on 2009-03-11 13:53:23 as
	PARP inhibitors for cancer therapy. [My Copy] Expert reviews in molecular medicine, Vol. 7, No. 4. (15 March 2005), pp. 1-20. by N. J. Curtin posted to cancer parp by catcremona on 2009-02-20 17:14:28 as
	Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. [My Copy] Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, No. 23. (1 December 2008), pp. 7917-7923. by R. Plummer, C. Jones, M. Middleton, et al.R. Wilson, J. Evans, A. Olsen, N. Curtin, A. Boddy, P. McHugh, D. Newell, A. Harris, P. Johnson, H. Steinfeldt, R. Dewji, D. Wang, L. Robson, H. Calvert posted to cancer inhibitor parp by catcremona on 2009-02-20 17:09:12 as
	Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [My Copy] Nature, Vol. 434, No. 7035. (14 April 2005), pp. 913-917. by Helen E. Bryant, Niklas Schultz, Huw D. Thomas, et al.Kayan M. Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J. Curtin, Thomas Helleday posted to brca dna parp repair by catcremona on 2009-02-20 17:04:02 as along with 1 person skoch3
	Poly ADP-ribose polymerase-1: An international molecule of mystery. [My Copy] DNA repair, Vol. 7, No. 7. (1 July 2008), pp. 1077-1086. by B. C. Woodhouse, G. L. Dianov posted to parp by guhjy on 2009-01-25 04:28:15 as along with 1 person moonycinzia
	Poly(ADP-ribose) polymerase activity in different pathologies--the link to inflammation and infarction. [My Copy] Experimental gerontology, Vol. 43, No. 7. (July 2008), pp. 605-614. by S. Beneke posted to parp by guhjy on 2009-01-25 04:27:01 as
	Angiotensin II promotes poly(ADP-ribosyl)ation of c-Jun/c-Fos in cardiac fibroblasts [My Copy] Journal of Molecular and Cellular Cardiology, Vol. 46, No. 1. (January 2009), pp. 25-32. by D. Huang, Y. Wang, C. Yang, Y. Liao, K. Huang posted to aii fbl jun parp by guhjy on 2009-01-25 03:55:40 as
	The role of poly(ADP-ribosyl)ation in epigenetic events. [My Copy] The international journal of biochemistry & cell biology, Vol. 41, No. 1. (January 2009), pp. 60-65. by Delphine Quénet, Rosy El Ramy, Valérie Schreiber, Françoise Dantzer posted to epigenetics parp by guhjy on 2009-01-25 03:46:34 as
	High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. [My Copy] Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 44. (4 November 2008), pp. 17079-17084. by S. Rottenberg, J. E. Jaspers, A. Kersbergen, et al.E. van der Burg, A. O. Nygren, S. A. Zander, P. W. Derksen, M. de Bruin, J. Zevenhoven, A. Lau, R. Boulter, A. Cranston, M. J. O'Connor, N. M. Martin, P. Borst, J. Jonkers posted to brca1 breast cancer inhibitor parp treatment by catcremona on 2009-01-23 15:08:35 as
	The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series [My Copy] EMBO Reports, Vol. aop, No. current. (31 October 2008) by Antoinette Hakme, Heng-Kuan Wong, Francoise Dantzer, Valerie Schreiber posted to parp by guhjy on 2008-11-17 14:46:25 as

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dnadamagerepair	23
ageing	17
par	16
topoisomerasi	14
p53	13
apoptosis	12
genomicstability	11
chromatinremodeling	8
ddr	8
nadnadh	8
atm	7
parpbinding	7
telomeres	7
topoisomerase	7
nadh	6
brca1	5
cancer	5
histones	5
nicotinamide	5
parpinhibition	5
sir2	5
tankyrase	5
brca1_and_brca2	4
brca2	4
dna	4
inhibitor	4
nad	4
oxidativestress	4
repair	4
ribosylation	4
wrn	4
brain	3
chromatin	3
ctcf	3
dn	3
inflammation	3
methods	3
mitochondria	3
oct30	3
olaparib	3
centrosome	2
centrosomes	2
diabetes	2
epigenetics	2
interaction	2
ischemia	2
necrosis	2
nf-kappab	2
nucleolus	2
parpdeficiency	2
parpdnainteraction	2
proteasomes	2
rat	2
ros	2
sce	2
sirt	2
sirt1	2
stz	2
treatment	2
adp-ribose	1
adp-ribosylation	1
aif	1
aii	1
ampk	1
b23	1
ber	1
breast	1
breast-cancer	1
carcinogenesis	1
caspase	1
cpt	1
dbdb	1
dm	1
dna_repair	1
dna_strand_breaks	1
drug	1
et	1
fbl	1
hsp90	1
kif4	1
lkb	1
mouse	1
nfkb	1
nmr	1
nucleophosmin	1
nucleus	1
oct_30	1
ovarian	1
parg	1
parp_inhibitor	1
phosphorylation	1
platinum	1
polyadp-ribose	1
polyadp-ribosylation	1
radiosensitization	1
remodelling	1
stress	1
sumo	1
tgfb	1
vparp	1

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