Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal–fetal immune tolerance Export

@article{citeulike:3494576, abstract = {10.1073/pnas.0807606105 Galectin-1 is an anti-inflammatory lectin with pleiotropic regulatory functions at the crossroads of innate and adaptive immunity. It is expressed in immune privileged sites and is implicated in establishing maternal–fetal immune tolerance, which is essential for successful pregnancy in eutherian mammals. Here, we show conserved placental localization of galectin-1 in primates and its predominant expression in maternal decidua. Phylogenetic footprinting and shadowing unveil conserved motifs, including an estrogen responsive element in the 5′ promoter of , that were gained during the emergence of placental mammals and could account for sex steroid regulation of expression, thus providing additional evidence for the role of galectin-1 in immune–endocrine cross-talk. Maximum parsimony and maximum likelihood analyses of 27 publicly available vertebrate and seven newly sequenced primate coding sequences reveal that intense purifying selection has been acting on residues in the carbohydrate recognition domain and dimerization interface that are involved in immune functions. Parsimony- and codon model-based phylogenetic analysis of coding sequences show that amino acid replacements occurred in early mammalian evolution on key residues, including gain of cysteines, which regulate immune functions by redox status-mediated conformational changes that disable sugar binding and dimerization, and that the acquired immunoregulatory functions of galectin-1 then became highly conserved in eutherian lineages, suggesting the emergence of hormonal and redox regulation of galectin-1 in placental mammals may be implicated in maternal–fetal immune tolerance.}, author = {Than, Nandor G. and Romero, Roberto and Erez, Offer and Weckle, Amy and Tarca, Adi L. and Hotra, John and Abbas, Asad and Han, Yu M. and Kim, Sung-Su and Kusanovic, Juan P. and Gotsch, Francesca and Hou, Zhuocheng and Santolaya-Forgas, Joaquin and Benirschke, Kurt and Papp, Zoltan and Grossman, Lawrence I. and Goodman, Morris and Wildman, Derek E.}, citeulike-article-id = {3494576}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0807606105}, citeulike-linkout-1 = {http://www.pnas.org/content/105/41/15819.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/41/15819.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18824694}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18824694}, day = {14}, doi = {10.1073/pnas.0807606105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {immunology, interface, maternal-fetal, pregnancy}, month = {October}, number = {41}, pages = {15819--15824}, posted-at = {2008-11-07 21:19:03}, priority = {2}, title = {Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal–fetal immune tolerance}, url = {http://dx.doi.org/10.1073/pnas.0807606105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3494576 L3 - citeulike-article-id:3494576 N2 - 10.1073/pnas.0807606105 Galectin-1 is an anti-inflammatory lectin with pleiotropic regulatory functions at the crossroads of innate and adaptive immunity. It is expressed in immune privileged sites and is implicated in establishing maternal–fetal immune tolerance, which is essential for successful pregnancy in eutherian mammals. Here, we show conserved placental localization of galectin-1 in primates and its predominant expression in maternal decidua. Phylogenetic footprinting and shadowing unveil conserved motifs, including an estrogen responsive element in the 5′ promoter of , that were gained during the emergence of placental mammals and could account for sex steroid regulation of expression, thus providing additional evidence for the role of galectin-1 in immune–endocrine cross-talk. Maximum parsimony and maximum likelihood analyses of 27 publicly available vertebrate and seven newly sequenced primate coding sequences reveal that intense purifying selection has been acting on residues in the carbohydrate recognition domain and dimerization interface that are involved in immune functions. Parsimony- and codon model-based phylogenetic analysis of coding sequences show that amino acid replacements occurred in early mammalian evolution on key residues, including gain of cysteines, which regulate immune functions by redox status-mediated conformational changes that disable sugar binding and dimerization, and that the acquired immunoregulatory functions of galectin-1 then became highly conserved in eutherian lineages, suggesting the emergence of hormonal and redox regulation of galectin-1 in placental mammals may be implicated in maternal–fetal immune tolerance. IS - 41 JF - Proceedings of the National Academy of Sciences EP - 15824 TI - Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal–fetal immune tolerance VL - 105 SP - 15819 KW - immunology KW - interface KW - maternal-fetal KW - pregnancy AU - Than, Nandor AU - Romero, Roberto AU - Erez, Offer AU - Weckle, Amy AU - Tarca, Adi AU - Hotra, John AU - Abbas, Asad AU - Han, Yu AU - Kim, Sung-Su AU - Kusanovic, Juan AU - Gotsch, Francesca AU - Hou, Zhuocheng AU - Santolaya-Forgas, Joaquin AU - Benirschke, Kurt AU - Papp, Zoltan AU - Grossman, Lawrence AU - Goodman, Morris AU - Wildman, Derek PY - 2008/10/14/ UR - http://dx.doi.org/10.1073/pnas.0807606105 ER -