NKT Cells at the Maternal-Fetal Interface Export

@article{citeulike:3494577, abstract = {Establishment of the maternal-fetal interface is characterized by the influx of maternal NK cells, macrophages, and T cells into the decidua. Although a great deal has been learned about the function of NK cells in the decidua, comparatively little is known of decidual T cell function. NKT cells are an unusual T cell subset capable of producing both Th1-like and Th2-like cytokines. Unlike conventional \&agr;\&b.beta; T cells that recognize peptides in the context of MHC molecules, NKT cells recognize glycolipids presented by the MHC class I-like molecule, CD1d. Recent reports have demonstrated that NKT cells and CD1d are present at the maternal-fetal interface. Moreover, activation of NKT cells can have dramatic effects on pregnancy. In this article, we will review basic aspects of NKT cell biology and summarize the recent literature on NKT cells at the maternal-fetal interface.}, author = {Boyson, J. E. and Aktan, I. and Barkhuff, D. A. and Chant, A.}, citeulike-article-id = {3494577}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/08820130802191409}, doi = {10.1080/08820130802191409}, journal = {Immunological Investigations}, keywords = {interface, maternal-fetal, nk}, number = {5}, pages = {565--582}, posted-at = {2008-11-07 21:20:45}, priority = {2}, publisher = {Informa Healthcare}, title = {NKT Cells at the Maternal-Fetal Interface}, url = {http://dx.doi.org/10.1080/08820130802191409}, volume = {37}, year = {2008} }

TY - JOUR ID - citeulike:3494577 L3 - citeulike-article-id:3494577 N2 - Establishment of the maternal-fetal interface is characterized by the influx of maternal NK cells, macrophages, and T cells into the decidua. Although a great deal has been learned about the function of NK cells in the decidua, comparatively little is known of decidual T cell function. NKT cells are an unusual T cell subset capable of producing both Th1-like and Th2-like cytokines. Unlike conventional &agr;&b.beta; T cells that recognize peptides in the context of MHC molecules, NKT cells recognize glycolipids presented by the MHC class I-like molecule, CD1d. Recent reports have demonstrated that NKT cells and CD1d are present at the maternal-fetal interface. Moreover, activation of NKT cells can have dramatic effects on pregnancy. In this article, we will review basic aspects of NKT cell biology and summarize the recent literature on NKT cells at the maternal-fetal interface. IS - 5 JF - Immunological Investigations EP - 582 TI - NKT Cells at the Maternal-Fetal Interface PB - Informa Healthcare VL - 37 SP - 565 KW - interface KW - maternal-fetal KW - nk AU - Boyson, JE AU - Aktan, I AU - Barkhuff, DA AU - Chant, A PY - 2008/// UR - http://dx.doi.org/10.1080/08820130802191409 ER -