Role of Dendritic Cells in the Regulation of Maternal Immune Responses to the Fetus During Mammalian Gestation Export

@article{citeulike:3494602, abstract = {Successful mammalian pregnancy relies on the action of sophisticated regulatory mechanisms that allow the fetus (a semi-allograft) to grow and develop in the uterus in spite of being recognized by maternal immune cells. Among several immunocompetent cells present at the maternal fetal interface, dendritic cells (DC) seem to be of particular relevance for pregnancy maintenance given their unique ability to induce both antigen-specific immunity and tolerance. Thus, these cells would be potentially suitable candidates for the regulation of local immune responses within the uterus necessary to meet the difficult task of protecting the mother from infection without compromising fetal survival. Current evidence on decidual DC phenotype and function, and their role in the regulation of the maternal immune system during mouse and human pregnancy are discussed and reviewed herein; highlighting novel DC functions that seem to be of great importance for a succesful pregnancy outcome.}, author = {Kammerer, Ulrike and Kruse, Andrea and Barrientos, Gabriela and Arck, Petra C. and Blois, Sandra M.}, citeulike-article-id = {3494602}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/08820130802191334}, doi = {10.1080/08820130802191334}, journal = {Immunological Investigations}, keywords = {cells, dendritic, immunology, interface, maternal-fetal, pregnancy}, number = {5}, pages = {499--533}, posted-at = {2008-11-07 22:04:37}, priority = {3}, publisher = {Informa Healthcare}, title = {Role of Dendritic Cells in the Regulation of Maternal Immune Responses to the Fetus During Mammalian Gestation}, url = {http://dx.doi.org/10.1080/08820130802191334}, volume = {37}, year = {2008} }

TY - JOUR ID - citeulike:3494602 L3 - citeulike-article-id:3494602 N2 - Successful mammalian pregnancy relies on the action of sophisticated regulatory mechanisms that allow the fetus (a semi-allograft) to grow and develop in the uterus in spite of being recognized by maternal immune cells. Among several immunocompetent cells present at the maternal fetal interface, dendritic cells (DC) seem to be of particular relevance for pregnancy maintenance given their unique ability to induce both antigen-specific immunity and tolerance. Thus, these cells would be potentially suitable candidates for the regulation of local immune responses within the uterus necessary to meet the difficult task of protecting the mother from infection without compromising fetal survival. Current evidence on decidual DC phenotype and function, and their role in the regulation of the maternal immune system during mouse and human pregnancy are discussed and reviewed herein; highlighting novel DC functions that seem to be of great importance for a succesful pregnancy outcome. IS - 5 JF - Immunological Investigations EP - 533 TI - Role of Dendritic Cells in the Regulation of Maternal Immune Responses to the Fetus During Mammalian Gestation PB - Informa Healthcare VL - 37 SP - 499 KW - cells KW - dendritic KW - immunology KW - interface KW - maternal-fetal KW - pregnancy AU - Kammerer, Ulrike AU - Kruse, Andrea AU - Barrientos, Gabriela AU - Arck, Petra AU - Blois, Sandra PY - 2008/// UR - http://dx.doi.org/10.1080/08820130802191334 ER -