Induction, function and regulation of IL-17-producing T cells Export

@article{citeulike:3933700, abstract = {Recent reports have provided convincing evidence that IL-17-producing T cells play a key role in the pathogenesis of organ-specific autoimmune diseases, a function previously attributed exclusively to IFN-gamma-secreting Th1 cells. Furthermore, it appears that IL-17-producing T cells can also function with Th1 cells to mediate protective immunity to pathogens. Although much of the focus has been on IL-17-secreting CD4+ T cells, termed Th17 cells, CD8+ T cells, gammadelta T cells and NKT cells are also capable of secreting IL-17. The differentiation of Th17 cells from na\"{i}ve T cells appears to involve signals from TGF-beta, IL-6, IL-21, IL-1beta and IL-23. Furthermore, IL-1alpha or IL-1beta in synergy with IL-23 can promote IL-17 secretion from memory T cells. The induction or function of Th17 cells is regulated by cytokines secreted by the other major subtypes of T cells, including IFN-gamma, IL-4, IL-10 and at high concentrations, TGF-beta. The main function of IL-17-secreting T cells is to mediate inflammation, by stimulating production of inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6, and inflammatory chemokines that promote the recruitment of neutrophils and macrophages.}, address = {Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland}, author = {Mills, Kingston H. G.}, citeulike-article-id = {3933700}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/eji.200838535}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121489807/ABSTRACT}, doi = {10.1002/eji.200838535}, journal = {European Journal of Immunology}, keywords = {cells, cytokine, il-17, t}, number = {10}, pages = {2636--2649}, posted-at = {2009-01-23 19:48:09}, priority = {3}, title = {Induction, function and regulation of IL-17-producing T cells}, url = {http://dx.doi.org/10.1002/eji.200838535}, volume = {38}, year = {2008} }

TY - JOUR ID - citeulike:3933700 L3 - citeulike-article-id:3933700 N2 - Recent reports have provided convincing evidence that IL-17-producing T cells play a key role in the pathogenesis of organ-specific autoimmune diseases, a function previously attributed exclusively to IFN-gamma-secreting Th1 cells. Furthermore, it appears that IL-17-producing T cells can also function with Th1 cells to mediate protective immunity to pathogens. Although much of the focus has been on IL-17-secreting CD4+ T cells, termed Th17 cells, CD8+ T cells, gammadelta T cells and NKT cells are also capable of secreting IL-17. The differentiation of Th17 cells from naïve T cells appears to involve signals from TGF-beta, IL-6, IL-21, IL-1beta and IL-23. Furthermore, IL-1alpha or IL-1beta in synergy with IL-23 can promote IL-17 secretion from memory T cells. The induction or function of Th17 cells is regulated by cytokines secreted by the other major subtypes of T cells, including IFN-gamma, IL-4, IL-10 and at high concentrations, TGF-beta. The main function of IL-17-secreting T cells is to mediate inflammation, by stimulating production of inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6, and inflammatory chemokines that promote the recruitment of neutrophils and macrophages. IS - 10 JF - European Journal of Immunology AD - Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland EP - 2649 TI - Induction, function and regulation of IL-17-producing T cells VL - 38 SP - 2636 KW - cells KW - cytokine KW - il-17 KW - t AU - Mills, Kingston PY - 2008/// UR - http://dx.doi.org/10.1002/eji.200838535 ER -