Chemotactically active proteins of neutrophils. Export

@article{citeulike:4095286, abstract = {Polymorphonuclear leukocytes (neutrophils) are the first cells that arrive at sites of infection or injury. There, besides their microorganism-targeted effector functions, activated neutrophils secrete numerous chemoattractants that recruit other leukocyte subtypes into the inflamed tissue. First, neutrophil activation leads to the upregulation of the gene expression of several classical chemokines of the CXC and CC families. Second, neutrophil granules contain preformed intracellular storage pools of chemotactically active proteins that are rapidly released upon neutrophil degranulation. The third pathway of generation of chemotactically active proteins by activated neutrophils--shedding and concomitant proteolytic processing of a membrane protein--has recently been demonstrated in our laboratory. In this review, we summarize the essential features of chemoattractant production by neutrophils and their contribution to orchestrating the recruitment of leukocyte subtypes during inflammatory response.}, author = {Pliyev, B. K.}, citeulike-article-id = {4095286}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18976213}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18976213}, issn = {1608-3040}, journal = {Biochemistry. Biokhimii͡a}, keywords = {cells, chemokines, immunology, neutrophils, pmn}, month = {September}, number = {9}, pages = {970--984}, posted-at = {2009-02-24 19:24:24}, priority = {0}, title = {Chemotactically active proteins of neutrophils.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18976213}, volume = {73}, year = {2008} }

TY - JOUR ID - citeulike:4095286 L3 - citeulike-article-id:4095286 N2 - Polymorphonuclear leukocytes (neutrophils) are the first cells that arrive at sites of infection or injury. There, besides their microorganism-targeted effector functions, activated neutrophils secrete numerous chemoattractants that recruit other leukocyte subtypes into the inflamed tissue. First, neutrophil activation leads to the upregulation of the gene expression of several classical chemokines of the CXC and CC families. Second, neutrophil granules contain preformed intracellular storage pools of chemotactically active proteins that are rapidly released upon neutrophil degranulation. The third pathway of generation of chemotactically active proteins by activated neutrophils--shedding and concomitant proteolytic processing of a membrane protein--has recently been demonstrated in our laboratory. In this review, we summarize the essential features of chemoattractant production by neutrophils and their contribution to orchestrating the recruitment of leukocyte subtypes during inflammatory response. IS - 9 JF - Biochemistry. Biokhimii͡a SN - 1608-3040 EP - 984 TI - Chemotactically active proteins of neutrophils. VL - 73 SP - 970 KW - cells KW - chemokines KW - immunology KW - neutrophils KW - pmn AU - Pliyev, BK PY - 2008/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/18976213 ER -