Lateral Diffusion in Lipid Membranes through Collective Flows Export

@article{citeulike:2254132, abstract = {Abstract: There is no comprehensive model for the dynamics of cellular membranes. Even mechanisms of basic dynamic processes, such as lateral diffusion of lipids, are poorly understood. Our atomic-scale molecular dynamics simulations support a novel, concerted mechanism for lipid diffusion. We find that a lipid and its nearest neighbors move in unison, forming loosely defined clusters. What is more, the motions of lipids are correlated over tens of nanometers: the lateral displacements of lipids in a given monolayer produce striking two-dimensional flow patterns. These flow patterns should have wide implications, affecting, for example, the formation of membrane domains, protein functionality, and action of lipases and drugs on membranes.}, address = {Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Finland, Beckman Institute for Advanced Science and Technology, University of Urbana-Champaign, Urbana, Illinois, Faculty of Electrical Engineering, Helsinki University of Technology, Finland, Department of Biophysics, Jagiellonian University, Poland, Department of Applied Mathematics, The University of Western Ontario, Middlesex College, London (ON), Canada, MEMPHYS-Center for Biomembrane Physics, University of Southern Denmark, and Institute of Physics, Tampere University of Technology, Tampere, Finland}, author = {Falck, E. and Rog, T. and Karttunen, M. and Vattulainen, I.}, citeulike-article-id = {2254132}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/ja7103558}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/ja7103558}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18078342}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18078342}, day = {9}, doi = {10.1021/ja7103558}, journal = {J. Am. Chem. Soc.}, keywords = {collective, diffusion, later, lipid, membranes}, month = {January}, number = {1}, pages = {44--45}, posted-at = {2008-08-22 14:19:22}, priority = {2}, title = {Lateral Diffusion in Lipid Membranes through Collective Flows}, url = {http://dx.doi.org/10.1021/ja7103558}, volume = {130}, year = {2008} }

TY - JOUR ID - citeulike:2254132 L3 - citeulike-article-id:2254132 N2 - Abstract: There is no comprehensive model for the dynamics of cellular membranes. Even mechanisms of basic dynamic processes, such as lateral diffusion of lipids, are poorly understood. Our atomic-scale molecular dynamics simulations support a novel, concerted mechanism for lipid diffusion. We find that a lipid and its nearest neighbors move in unison, forming loosely defined clusters. What is more, the motions of lipids are correlated over tens of nanometers: the lateral displacements of lipids in a given monolayer produce striking two-dimensional flow patterns. These flow patterns should have wide implications, affecting, for example, the formation of membrane domains, protein functionality, and action of lipases and drugs on membranes. IS - 1 JF - J. Am. Chem. Soc. AD - Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Finland, Beckman Institute for Advanced Science and Technology, University of Urbana-Champaign, Urbana, Illinois, Faculty of Electrical Engineering, Helsinki University of Technology, Finland, Department of Biophysics, Jagiellonian University, Poland, Department of Applied Mathematics, The University of Western Ontario, Middlesex College, London (ON), Canada, MEMPHYS-Center for Biomembrane Physics, University of Southern Denmark, and Institute of Physics, Tampere University of Technology, Tampere, Finland EP - 45 TI - Lateral Diffusion in Lipid Membranes through Collective Flows VL - 130 SP - 44 KW - collective KW - diffusion KW - later KW - lipid KW - membranes AU - Falck, E AU - Rog, T AU - Karttunen, M AU - Vattulainen, I PY - 2008/01/09/ UR - http://dx.doi.org/10.1021/ja7103558 ER -