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Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

by: Stephen Malin, Shane McManus, Cesar Cobaleda, Maria Novatchkova, Alessio Delogu, Philippe Bouillet, Andreas Strasser, Meinrad Busslinger
Nat Immunol, Vol. 11, No. 2. (29 February 2010), pp. 171-179, doi:10.1038/ni.1827  Key: citeulike:6565155

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Abstract

B cell development requires interleukin 7 signals that activate the transcription factor STAT5. Busslinger and colleagues report that STAT5 has a permissive rather than instructive role in pro-B cell survival and immunoglobulin recombination.


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