Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells Export

@article{citeulike:1363801, abstract = {Engaging mammalian Toll-like receptors (TLRs) activate both the NF-{kappa}B and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1-/- cells, is required for extracellular signal-regulated kinase (ERK) activation in bone marrow-derived macrophages and B cells stimulated with diverse TLR ligands. Despite rescuing TLR-dependent ERK activation in nfkb1-/- bone marrow-derived macrophages by using an estrogen receptor-regulated version of the mitogen-activated protein 3 kinase, c-Raf (Raf:ER), CpG or LPS induction of IL-10 was only partially restored in nfkb1-/- cells expressing Raf:ER, a finding consistent with NF-{kappa}B1 regulating IL-10 by a combination of ERK-independent and -dependent mechanisms. Collectively, our findings indicate that the Tpl2/MEK/ERK signaling module is a master regulator of ERK-dependent gene expression downstream of TLRs in different hemopoietic cells. 10.1073/pnas.0511113103}, author = {Banerjee, Ashish and Gugasyan, Raffi and Mcmahon, Martin and Gerondakis, Steve}, citeulike-article-id = {1363801}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0511113103}, citeulike-linkout-1 = {http://www.pnas.org/cgi/content/abstract/103/9/3274}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16484370}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16484370}, day = {28}, doi = {10.1073/pnas.0511113103}, journal = {PNAS}, keywords = {erk-il-10}, month = {February}, number = {9}, pages = {3274--3279}, posted-at = {2007-06-04 22:14:39}, priority = {2}, title = {Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells}, url = {http://dx.doi.org/10.1073/pnas.0511113103}, volume = {103}, year = {2006} }

TY - JOUR ID - citeulike:1363801 L3 - citeulike-article-id:1363801 N2 - Engaging mammalian Toll-like receptors (TLRs) activate both the NF-{kappa}B and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1-/- cells, is required for extracellular signal-regulated kinase (ERK) activation in bone marrow-derived macrophages and B cells stimulated with diverse TLR ligands. Despite rescuing TLR-dependent ERK activation in nfkb1-/- bone marrow-derived macrophages by using an estrogen receptor-regulated version of the mitogen-activated protein 3 kinase, c-Raf (Raf:ER), CpG or LPS induction of IL-10 was only partially restored in nfkb1-/- cells expressing Raf:ER, a finding consistent with NF-{kappa}B1 regulating IL-10 by a combination of ERK-independent and -dependent mechanisms. Collectively, our findings indicate that the Tpl2/MEK/ERK signaling module is a master regulator of ERK-dependent gene expression downstream of TLRs in different hemopoietic cells. 10.1073/pnas.0511113103 IS - 9 JF - PNAS EP - 3279 TI - Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells VL - 103 SP - 3274 KW - erk-il-10 AU - Banerjee, Ashish AU - Gugasyan, Raffi AU - Mcmahon, Martin AU - Gerondakis, Steve PY - 2006/02/28/ UR - http://dx.doi.org/10.1073/pnas.0511113103 ER -