Intracellular NOD-like Receptors in Host Defense and Disease Export

@article{citeulike:2814420, abstract = {The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOD1 and NOD2, sense the cytosolic presence of the peptidoglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-[kappa]B. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases.}, author = {Kanneganti, Thirumala-Devi and Lamkanfi, Mohamed and N\'{u}\~{n}ez, Gabriel}, citeulike-article-id = {2814420}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2007.10.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17967410}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17967410}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSP-4R060NB-7/1/a355d63182e56fcae6a51b7b069118f2}, day = {26}, doi = {10.1016/j.immuni.2007.10.002}, journal = {Immunity}, keywords = {ccfa, prrs}, month = {October}, number = {4}, pages = {549--559}, posted-at = {2008-05-19 23:42:10}, priority = {2}, title = {Intracellular NOD-like Receptors in Host Defense and Disease}, url = {http://dx.doi.org/10.1016/j.immuni.2007.10.002}, volume = {27}, year = {2007} }

TY - JOUR ID - citeulike:2814420 L3 - citeulike-article-id:2814420 N2 - The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we discuss the recent understanding in NLRs. Two NLRs, NOD1 and NOD2, sense the cytosolic presence of the peptidoglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase (MAPK) and the transcription factor NF-[kappa]B. A different set of NLRs induces caspase-1 activation through the assembly of large protein complexes named inflammasomes. Genetic variations in several NLR members are associated with the development of inflammatory disorders. Further understanding of NLRs should provide new insights into the mechanisms of host defense and the pathogenesis of inflammatory diseases. IS - 4 JF - Immunity EP - 559 TI - Intracellular NOD-like Receptors in Host Defense and Disease VL - 27 SP - 549 KW - ccfa KW - prrs AU - Kanneganti, Thirumala-Devi AU - Lamkanfi, Mohamed AU - Núñez, Gabriel PY - 2007/10/26/ UR - http://dx.doi.org/10.1016/j.immuni.2007.10.002 ER -