Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Export

@article{citeulike:3879957, abstract = {The CD40-CD154 pathway is important in the pathogenesis of inflammatory bowel disease. Here we show that injection of an agonistic CD40 mAb to T and B cell-deficient mice was sufficient to induce a pathogenic systemic and intestinal innate inflammatory response that was functionally dependent on tumor necrosis factor-alpha and interferon-gamma as well as interleukin-12 p40 and interleukin-23 p40 secretion. CD40-induced colitis, but not wasting disease or serum proinflammatory cytokine production, depended on interleukin-23 p19 secretion, whereas interleukin-12 p35 secretion controlled wasting disease and serum cytokine production but not mucosal immunopathology. Intestinal inflammation was associated with IL-23 (p19) mRNA-producing intestinal dendritic cells and IL-17A mRNA within the intestine. Our experiments identified IL-23 as an effector cytokine within the innate intestinal immune system. The differential role of IL-23 in local but not systemic inflammation suggests that it may make a more specific target for the treatment of IBD.}, author = {Uhlig, H. H. and McKenzie, B. S. and Hue, S. and Thompson, C. and Joyce-Shaikh, B. and Stepankova, R. and Robinson, N. and Buonocore, S. and Tlaskalova-Hogenova, H. and Cua, D. J. and Powrie, F.}, citeulike-article-id = {3879957}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2006.05.017}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16919486}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16919486}, doi = {10.1016/j.immuni.2006.05.017}, issn = {1074-7613}, journal = {Immunity}, keywords = {ccfa}, month = {August}, number = {2}, pages = {309--318}, posted-at = {2009-01-13 07:35:57}, priority = {2}, title = {Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.}, url = {http://dx.doi.org/10.1016/j.immuni.2006.05.017}, volume = {25}, year = {2006} }

TY - JOUR ID - citeulike:3879957 L3 - citeulike-article-id:3879957 N2 - The CD40-CD154 pathway is important in the pathogenesis of inflammatory bowel disease. Here we show that injection of an agonistic CD40 mAb to T and B cell-deficient mice was sufficient to induce a pathogenic systemic and intestinal innate inflammatory response that was functionally dependent on tumor necrosis factor-alpha and interferon-gamma as well as interleukin-12 p40 and interleukin-23 p40 secretion. CD40-induced colitis, but not wasting disease or serum proinflammatory cytokine production, depended on interleukin-23 p19 secretion, whereas interleukin-12 p35 secretion controlled wasting disease and serum cytokine production but not mucosal immunopathology. Intestinal inflammation was associated with IL-23 (p19) mRNA-producing intestinal dendritic cells and IL-17A mRNA within the intestine. Our experiments identified IL-23 as an effector cytokine within the innate intestinal immune system. The differential role of IL-23 in local but not systemic inflammation suggests that it may make a more specific target for the treatment of IBD. IS - 2 JF - Immunity SN - 1074-7613 EP - 318 TI - Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. VL - 25 SP - 309 KW - ccfa AU - Uhlig, HH AU - McKenzie, BS AU - Hue, S AU - Thompson, C AU - Joyce-Shaikh, B AU - Stepankova, R AU - Robinson, N AU - Buonocore, S AU - Tlaskalova-Hogenova, H AU - Cua, DJ AU - Powrie, F PY - 2006/08// UR - http://dx.doi.org/10.1016/j.immuni.2006.05.017 ER -