Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Export

@article{citeulike:4721841, abstract = {Inflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by dysfunctional innate and/or adaptive immunity. This aberrant immune response leads to the secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract and thus cause further inflammation. Interleukin-22 (IL-22) is a T helper 17 (Th17) T cell-associated cytokine that is bifunctional in that it has both proinflammatory and protective effects on tissues depending on the inflammatory context. We show herein that IL-22 protected mice from IBD. Interestingly, not only was this protection mediated by CD4+ T cells, but IL-22-expressing natural killer (NK) cells also conferred protection. In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues.}, author = {Zenewicz, L. A. and Yancopoulos, G. D. and Valenzuela, D. M. and Murphy, A. J. and Stevens, S. and Flavell, R. A.}, citeulike-article-id = {4721841}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2008.11.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1074761308005074}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19100701}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19100701}, doi = {10.1016/j.immuni.2008.11.003}, issn = {1097-4180}, journal = {Immunity}, keywords = {intestinal-nk}, month = {December}, number = {6}, pages = {947--957}, posted-at = {2009-06-02 18:49:01}, priority = {2}, title = {Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.}, url = {http://dx.doi.org/10.1016/j.immuni.2008.11.003}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:4721841 L3 - citeulike-article-id:4721841 N2 - Inflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by dysfunctional innate and/or adaptive immunity. This aberrant immune response leads to the secretion of harmful cytokines that destroy the epithelium of the gastrointestinal tract and thus cause further inflammation. Interleukin-22 (IL-22) is a T helper 17 (Th17) T cell-associated cytokine that is bifunctional in that it has both proinflammatory and protective effects on tissues depending on the inflammatory context. We show herein that IL-22 protected mice from IBD. Interestingly, not only was this protection mediated by CD4+ T cells, but IL-22-expressing natural killer (NK) cells also conferred protection. In addition, IL-22 expression was differentially regulated between NK cell subsets. Thus, both the innate and adaptive immune responses have developed protective mechanisms to counteract the damaging effects of inflammation on tissues. IS - 6 JF - Immunity SN - 1097-4180 EP - 957 TI - Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. VL - 29 SP - 947 KW - intestinal-nk AU - Zenewicz, LA AU - Yancopoulos, GD AU - Valenzuela, DM AU - Murphy, AJ AU - Stevens, S AU - Flavell, RA PY - 2008/12// UR - http://dx.doi.org/10.1016/j.immuni.2008.11.003 ER -