The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Export

@article{citeulike:477582, abstract = {Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-kappaB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes.}, address = {Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.}, author = {Yoneyama, M. and Kikuchi, M. and Natsukawa, T. and Shinobu, N. and Imaizumi, T. and Miyagishi, M. and Taira, K. and Akira, S. and Fujita, T.}, citeulike-article-id = {477582}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni1087}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ni1087}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15208624}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15208624}, doi = {10.1038/ni1087}, issn = {1529-2908}, journal = {Nat Immunol}, keywords = {ccfa, prrs, rig-1}, month = {July}, number = {7}, pages = {730--737}, posted-at = {2008-05-20 19:18:09}, priority = {2}, title = {The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.}, url = {http://dx.doi.org/10.1038/ni1087}, volume = {5}, year = {2004} }

TY - JOUR ID - citeulike:477582 L3 - citeulike-article-id:477582 N2 - Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-kappaB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes. IS - 7 JF - Nat Immunol SN - 1529-2908 AD - Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. EP - 737 TI - The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. VL - 5 SP - 730 KW - ccfa KW - prrs KW - rig-1 AU - Yoneyama, M AU - Kikuchi, M AU - Natsukawa, T AU - Shinobu, N AU - Imaizumi, T AU - Miyagishi, M AU - Taira, K AU - Akira, S AU - Fujita, T PY - 2004/07// UR - http://dx.doi.org/10.1038/ni1087 ER -