Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine Export

@article{citeulike:5038618, abstract = {Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4+ T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis. 10.1084/jem.20080720}, author = {Zaph, Colby and Du, Yurong and Saenz, Steven A. and Nair, Meera G. and Perrigoue, Jacqueline G. and Taylor, Betsy C. and Troy, Amy E. and Kobuley, Dmytro E. and Kastelein, Robert A. and Cua, Daniel J. and Yu, Yimin and Artis, David}, citeulike-article-id = {5038618}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20080720}, citeulike-linkout-1 = {http://jem.rupress.org/cgi/content/abstract/205/10/2191}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18762568}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18762568}, day = {29}, doi = {10.1084/jem.20080720}, journal = {J. Exp. Med.}, keywords = {ibd, th17}, month = {September}, number = {10}, pages = {2191--2198}, posted-at = {2009-07-02 02:56:01}, priority = {2}, title = {Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine}, url = {http://dx.doi.org/10.1084/jem.20080720}, volume = {205}, year = {2008} }

TY - JOUR ID - citeulike:5038618 L3 - citeulike-article-id:5038618 N2 - Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4+ T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis. 10.1084/jem.20080720 IS - 10 JF - J. Exp. Med. EP - 2198 TI - Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine VL - 205 SP - 2191 KW - ibd KW - th17 AU - Zaph, Colby AU - Du, Yurong AU - Saenz, Steven AU - Nair, Meera AU - Perrigoue, Jacqueline AU - Taylor, Betsy AU - Troy, Amy AU - Kobuley, Dmytro AU - Kastelein, Robert AU - Cua, Daniel AU - Yu, Yimin AU - Artis, David PY - 2008/09/29/ UR - http://dx.doi.org/10.1084/jem.20080720 ER -