Origin of the Lamina Propria Dendritic Cell Network Export

@article{citeulike:5816817, abstract = {CX3CR1+ and CD103+ dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear. We showed that monocytes gave rise exclusively to CD103CX3CR1+ lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands. In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs but not to monocytes, differentiated exclusively into CD103+CX3CR1 lamina propria DCs under the control of Flt3 and granulocyte-macrophage-colony-stimulating factor receptor (GM-CSFR) ligands. CD103+CX3CR1 DCs but not CD103CX3CR1+ DCs in the lamina propria constitutively expressed CCR7 and were the first DCs to transport pathogenic Salmonella from the intestinal tract to the mesenteric lymph nodes. Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system.}, author = {Bogunovic, Milena and Ginhoux, Florent and Helft, Julie and Shang, Limin and Hashimoto, Daigo and Greter, Melanie and Liu, Kang and Jakubzick, Claudia and Ingersoll, Molly A. and Leboeuf, Marylene and Stanley, E. Richard and Nussenzweig, Michel and Lira, Sergio A. and Randolph, Gwendalyn J. and Merad, Miriam}, citeulike-article-id = {5816817}, citeulike-linkout-0 = {http://www.cell.com/immunity/abstract/S1074-7613(09)00368-9}, comment = {References Network of dendritic cells within the muscular layer of the mouse intestine (Flores-Langarica 2005) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria (Macpherson and Uhr, 2004)** A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes(Huang et al., 2000) ---=note-separator=--- relation between CX3CR1+ DCs and CD103+ DCs is unclear ---=note-separator=--- macrophage and DC precursor (MDP)lineage−CD117hi CX3CR1+CD115+ -> Lymphoid tissue DCs, plasmacytoid DCs, monocytes common DC precursor (CDP) (Lin−CD117loCD115+ CD135+) -> Lymphoid tissue DCs, plasmacytoid DCs, pre cDC (blood circulating precursors) References supporting that monocytes represent a major contributor of the intestinal DC pool in the steady state ---=note-separator=--- In CCR7 -/- MLNs CD103+/low CD11b+ cells are gone (they are the ones that express CCR7)}, day = {18}, keywords = {intestinal-dcs}, month = {September}, number = {3}, pages = {513--525}, posted-at = {2009-09-21 23:32:45}, priority = {2}, title = {Origin of the Lamina Propria Dendritic Cell Network}, url = {http://www.cell.com/immunity/abstract/S1074-7613(09)00368-9}, volume = {31}, year = {2009} }

TY - JOUR ID - citeulike:5816817 L3 - citeulike-article-id:5816817 N2 - CX3CR1+ and CD103+ dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear. We showed that monocytes gave rise exclusively to CD103CX3CR1+ lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands. In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs but not to monocytes, differentiated exclusively into CD103+CX3CR1 lamina propria DCs under the control of Flt3 and granulocyte-macrophage-colony-stimulating factor receptor (GM-CSFR) ligands. CD103+CX3CR1 DCs but not CD103CX3CR1+ DCs in the lamina propria constitutively expressed CCR7 and were the first DCs to transport pathogenic Salmonella from the intestinal tract to the mesenteric lymph nodes. Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system. IS - 3 EP - 525 TI - Origin of the Lamina Propria Dendritic Cell Network VL - 31 SP - 513 KW - intestinal-dcs N1 - References Network of dendritic cells within the muscular layer of the mouse intestine (Flores-Langarica 2005) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria (Macpherson and Uhr, 2004)** A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes(Huang et al., 2000) N1 - relation between CX3CR1+ DCs and CD103+ DCs is unclear N1 - macrophage and DC precursor (MDP)lineage−CD117hi CX3CR1+CD115+ -> Lymphoid tissue DCs, plasmacytoid DCs, monocytes common DC precursor (CDP) (Lin−CD117loCD115+ CD135+) -> Lymphoid tissue DCs, plasmacytoid DCs, pre cDC (blood circulating precursors) References supporting that monocytes represent a major contributor of the intestinal DC pool in the steady state N1 - In CCR7 -/- MLNs CD103+/low CD11b+ cells are gone (they are the ones that express CCR7) AU - Bogunovic, Milena AU - Ginhoux, Florent AU - Helft, Julie AU - Shang, Limin AU - Hashimoto, Daigo AU - Greter, Melanie AU - Liu, Kang AU - Jakubzick, Claudia AU - Ingersoll, Molly AU - Leboeuf, Marylene AU - Stanley, Richard AU - Nussenzweig, Michel AU - Lira, Sergio AU - Randolph, Gwendalyn AU - Merad, Miriam PY - 2009/09/18/ UR - http://www.cell.com/immunity/abstract/S1074-7613(09)00368-9 ER -