Attention-Deficit/Hyperactivity-Related Symptoms Among Children With Enterovirus 71 Infection of the Central Nervous System. Export

@article{citeulike:3000687, abstract = {BACKGROUND. No study has investigated the association between enterovirus 71 central nervous system infection and symptoms related to attention-deficit/hyperactivity disorder. In this study we evaluated attention-deficit/hyperactivity disorder-related symptoms and internalizing problems as long-term sequelae resulting from enterovirus 71 central nervous system infection in children. METHODS. We enrolled 86 children 4 to 16 years old with virus-culture-confirmed enterovirus 71 infection and central nervous system involvement diagnosed 3 to 7 years before the study and 172 control subjects, matched for age, gender, and parents' education levels. Their mothers and teachers were asked to report on possible attention-deficit/hyperactivity disorder-related symptoms, and their mothers were asked to report on possible internalizing problems. All of the children previously infected with enterovirus 71 received intelligence tests. RESULTS. Forty-two (49\%) of the children previously infected with enterovirus 71 had had viral meningitis; 35 (41\%) had severe central nervous system involvement, such as encephalitis, poliomyelitis-like syndrome, or encephalomyelitis; and 9 (10\%) had cardiopulmonary failure and central nervous system involvement. The children previously infected with enterovirus 71 had higher scores than matched control subjects on teacher- and mother-rated scales of inattention, hyperactivity-impulsivity, oppositional symptoms, and attention-deficit/hyperactivity disorder index. The rate of elevated attention-deficit/hyperactivity disorder-related symptoms among children with enterovirus 71 central nervous system infection was 20\%, whereas that rate among matched control subjects was only 3\%. They also had more internalizing problems. Their verbal and performance IQs, as well as verbal comprehension indices, were significantly inversely correlated with symptoms of inattention, hyperactivity-impulsivity, and attention-deficit/hyperactivity disorder index scores. CONCLUSIONS. Enterovirus 71 central nervous system infection may affect long-term regulation of attention and emotion and cause hyperactivity-impulsivity in children.}, address = {aDepartments of Psychiatry.}, author = {Gau, Susan Shur-Fen S. and Chang, Luan-Yin Y. and Huang, Li-Min M. and Fan, Tsui-Yen Y. and Wu, Yu-Yu Y. and Lin, Tzou-Yien Y.}, citeulike-article-id = {3000687}, citeulike-linkout-0 = {http://dx.doi.org/10.1542/peds.2007-3799}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18606624}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18606624}, day = {7}, doi = {10.1542/peds.2007-3799}, issn = {1098-4275}, journal = {Pediatrics}, keywords = {adhd, enterovirus}, month = {July}, posted-at = {2008-07-15 02:12:45}, priority = {2}, title = {Attention-Deficit/Hyperactivity-Related Symptoms Among Children With Enterovirus 71 Infection of the Central Nervous System.}, url = {http://dx.doi.org/10.1542/peds.2007-3799}, year = {2008} }

TY - JOUR ID - citeulike:3000687 L3 - citeulike-article-id:3000687 N2 - BACKGROUND. No study has investigated the association between enterovirus 71 central nervous system infection and symptoms related to attention-deficit/hyperactivity disorder. In this study we evaluated attention-deficit/hyperactivity disorder-related symptoms and internalizing problems as long-term sequelae resulting from enterovirus 71 central nervous system infection in children. METHODS. We enrolled 86 children 4 to 16 years old with virus-culture-confirmed enterovirus 71 infection and central nervous system involvement diagnosed 3 to 7 years before the study and 172 control subjects, matched for age, gender, and parents' education levels. Their mothers and teachers were asked to report on possible attention-deficit/hyperactivity disorder-related symptoms, and their mothers were asked to report on possible internalizing problems. All of the children previously infected with enterovirus 71 received intelligence tests. RESULTS. Forty-two (49%) of the children previously infected with enterovirus 71 had had viral meningitis; 35 (41%) had severe central nervous system involvement, such as encephalitis, poliomyelitis-like syndrome, or encephalomyelitis; and 9 (10%) had cardiopulmonary failure and central nervous system involvement. The children previously infected with enterovirus 71 had higher scores than matched control subjects on teacher- and mother-rated scales of inattention, hyperactivity-impulsivity, oppositional symptoms, and attention-deficit/hyperactivity disorder index. The rate of elevated attention-deficit/hyperactivity disorder-related symptoms among children with enterovirus 71 central nervous system infection was 20%, whereas that rate among matched control subjects was only 3%. They also had more internalizing problems. Their verbal and performance IQs, as well as verbal comprehension indices, were significantly inversely correlated with symptoms of inattention, hyperactivity-impulsivity, and attention-deficit/hyperactivity disorder index scores. CONCLUSIONS. Enterovirus 71 central nervous system infection may affect long-term regulation of attention and emotion and cause hyperactivity-impulsivity in children. JF - Pediatrics SN - 1098-4275 AD - aDepartments of Psychiatry. TI - Attention-Deficit/Hyperactivity-Related Symptoms Among Children With Enterovirus 71 Infection of the Central Nervous System. KW - adhd KW - enterovirus AU - Gau, Susan Shur-Fen AU - Chang, Luan-Yin AU - Huang, Li-Min AU - Fan, Tsui-Yen AU - Wu, Yu-Yu AU - Lin, Tzou-Yien PY - 2008/07/07/ UR - http://dx.doi.org/10.1542/peds.2007-3799 ER -