Prenatal alcohol exposure and language delay in 2-year-old children: the importance of dose and timing on risk. Export

@article{citeulike:3998937, abstract = {OBJECTIVE: The aim of this study was to investigate the association of dose and timing of prenatal alcohol exposure with early language acquisition. METHODS: We examined language delay in a randomly selected, population-based sample of Western Australian children born in 1995-1996 whose mothers had agreed to participate in a longitudinal study on health-related behaviors and who had completed the 2-year questionnaire (N = 1739). Information on alcohol consumption was collected at 3 months after birth for four periods; the three months pre-pregnancy and for each trimester separately. Prenatal alcohol exposure was grouped into none, low, moderate-heavy and binge (>5) based on the total quantity consumed per week, quantity consumed per occasion, and frequency of consumption. The communication scale from the Ages \& Stages Questionnaire was used to evaluate language delay. Logistic regression analysis was used to generate odds ratios and 95\% confidence intervals, adjusted for confounding factors. RESULTS: There was no association between low levels of alcohol consumption and language delay at any time period, although there was a nonsignificant 30\% increase in risk when moderate-to-heavy levels of alcohol were consumed in the third trimester. Children exposed to a binge pattern of maternal alcohol consumption in the second trimester had nonsignificant, three-fold increased odds of language delay, with a similar estimate following third trimester alcohol exposure after controlling for covariates. CONCLUSIONS: This study did not detect an association between low levels of prenatal alcohol exposure and language delay when compared with women who abstained from alcohol during pregnancy. A nonsignificant threefold increase in the likelihood of language delay was seen in children whose mothers binged during late pregnancy. However, the small numbers of women with a binge-drinking pattern in late pregnancy limited the power of this study; studies analyzing larger numbers of children exposed to binge drinking in late pregnancy are needed.}, author = {O'Leary, C. and Zubrick, S. R. and Taylor, C. L. and Dixon, G. and Bower, C.}, citeulike-article-id = {3998937}, citeulike-linkout-0 = {http://dx.doi.org/10.1542/peds.2008-0459}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19171621}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19171621}, doi = {10.1542/peds.2008-0459}, issn = {1098-4275}, journal = {Pediatrics}, keywords = {alcohol, speech\_delay}, month = {February}, number = {2}, pages = {547--554}, posted-at = {2009-02-03 05:51:27}, priority = {2}, title = {Prenatal alcohol exposure and language delay in 2-year-old children: the importance of dose and timing on risk.}, url = {http://dx.doi.org/10.1542/peds.2008-0459}, volume = {123}, year = {2009} }

TY - JOUR ID - citeulike:3998937 L3 - citeulike-article-id:3998937 N2 - OBJECTIVE: The aim of this study was to investigate the association of dose and timing of prenatal alcohol exposure with early language acquisition. METHODS: We examined language delay in a randomly selected, population-based sample of Western Australian children born in 1995-1996 whose mothers had agreed to participate in a longitudinal study on health-related behaviors and who had completed the 2-year questionnaire (N = 1739). Information on alcohol consumption was collected at 3 months after birth for four periods; the three months pre-pregnancy and for each trimester separately. Prenatal alcohol exposure was grouped into none, low, moderate-heavy and binge (>5) based on the total quantity consumed per week, quantity consumed per occasion, and frequency of consumption. The communication scale from the Ages & Stages Questionnaire was used to evaluate language delay. Logistic regression analysis was used to generate odds ratios and 95% confidence intervals, adjusted for confounding factors. RESULTS: There was no association between low levels of alcohol consumption and language delay at any time period, although there was a nonsignificant 30% increase in risk when moderate-to-heavy levels of alcohol were consumed in the third trimester. Children exposed to a binge pattern of maternal alcohol consumption in the second trimester had nonsignificant, three-fold increased odds of language delay, with a similar estimate following third trimester alcohol exposure after controlling for covariates. CONCLUSIONS: This study did not detect an association between low levels of prenatal alcohol exposure and language delay when compared with women who abstained from alcohol during pregnancy. A nonsignificant threefold increase in the likelihood of language delay was seen in children whose mothers binged during late pregnancy. However, the small numbers of women with a binge-drinking pattern in late pregnancy limited the power of this study; studies analyzing larger numbers of children exposed to binge drinking in late pregnancy are needed. IS - 2 JF - Pediatrics SN - 1098-4275 EP - 554 TI - Prenatal alcohol exposure and language delay in 2-year-old children: the importance of dose and timing on risk. VL - 123 SP - 547 KW - alcohol KW - speech_delay AU - O'Leary, C AU - Zubrick, SR AU - Taylor, CL AU - Dixon, G AU - Bower, C PY - 2009/02// UR - http://dx.doi.org/10.1542/peds.2008-0459 ER -