Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with a Novel Agent, Hexadecylphospocholine (Miltefosine), in Combination with Terbinafine and Voriconazole: A Case Report Export

@article{citeulike:4241818, abstract = {doi: 10.1086/597772 PMID: 19320594 We describe an 8‐year‐old girl who sustained multiple compound fractures in an accident involving agricultural equipment. She developed Scedosporium prolificans osteomyelitis of the pelvis, septic arthritis of the hip, and myositis of adjacent muscles. The infection progressed, despite extensive surgical debridement and joint washouts with 0.2\% polyhexamethylene biguanide; antifungal therapy with caspofungin, terbinafine, and voriconazole; and adjunctive therapy with interferon‐γ. Gradual resolution was achieved after the addition of a novel agent, hexadecylphospocholine (miltefosine), and the continuation of terbinafine and voriconazole. This is the first report of the use of miltefosine as an antifungal agent in the management of severe infection with S. prolificans.}, author = {Kesson, Alison m and Bellemore, Michael c and O'mara, Timothy j and Ellis, David h and Sorrell, Tania c}, citeulike-article-id = {4241818}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/597772}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19320594}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19320594}, citeulike-linkout-3 = {http://www.journals.uchicago.edu/doi/abs/10.1086/597772}, doi = {10.1086/597772}, journal = {Clinical Infectious Diseases}, keywords = {osteomyelitis}, number = {0}, pages = {000}, posted-at = {2009-04-10 07:14:35}, priority = {2}, title = {Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with a Novel Agent, Hexadecylphospocholine (Miltefosine), in Combination with Terbinafine and Voriconazole: A Case Report}, url = {http://dx.doi.org/10.1086/597772}, volume = {0}, year = {0000} }

TY - JOUR ID - citeulike:4241818 L3 - citeulike-article-id:4241818 N2 - doi: 10.1086/597772 PMID: 19320594 We describe an 8‐year‐old girl who sustained multiple compound fractures in an accident involving agricultural equipment. She developed Scedosporium prolificans osteomyelitis of the pelvis, septic arthritis of the hip, and myositis of adjacent muscles. The infection progressed, despite extensive surgical debridement and joint washouts with 0.2% polyhexamethylene biguanide; antifungal therapy with caspofungin, terbinafine, and voriconazole; and adjunctive therapy with interferon‐γ. Gradual resolution was achieved after the addition of a novel agent, hexadecylphospocholine (miltefosine), and the continuation of terbinafine and voriconazole. This is the first report of the use of miltefosine as an antifungal agent in the management of severe infection with S. prolificans. IS - 0 JF - Clinical Infectious Diseases EP - 000 TI - Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with a Novel Agent, Hexadecylphospocholine (Miltefosine), in Combination with Terbinafine and Voriconazole: A Case Report VL - 0 SP - 000 KW - osteomyelitis AU - Kesson, Alison m AU - Bellemore, Michael c AU - O’mara, Timothy j AU - Ellis, David h AU - Sorrell, Tania c PY - 2000/// UR - http://dx.doi.org/10.1086/597772 ER -