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Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.by: J. W. Alffenaar, R. van Altena, H. J. Bökkerink, G. J. Luijckx, D. van Soolingen, R. E. Aarnoutse, T. S. van der Werf
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 49, No. 7. (1 October 2009), pp. 1080-1082.
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AbstractMoxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.
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