Serum Procalcitonin for Prediction of Renal Parenchymal Involvement in Children with Urinary Tract Infections: A Meta-analysis of Prospective Clinical Studies. Export

@article{citeulike:6014161, abstract = {OBJECTIVE: To determine by meta-analysis whether serum procalcitonin (PCT) is a useful marker of acute renal parenchymal involvement (RPI) in children with culture-proven urinary tract infection (UTI), as diagnosed by acute-phase DMSA (Tc-99m dimercaptosuccinic acid) renal scintigraphy. STUDY DESIGN: We searched PubMed and the Cochrane Central Register of Controlled Trials for prospective studies involving children with culture-proven UTIs. Additional eligibility criteria were measurement of serum PCT at presentation and performance of DMSA scintigraphy within 14 days. RESULTS: Overall, 10 studies eligible for inclusion, involving a total of 627 children, were identified. Half of these studies evaluated children with a first episode of UTI; 8 involved children with febrile UTIs. Using a cutoff value of 0.5 to 0.6 ng/mL, the pooled diagnostic odds ratio of serum PCT for UTI with RPI was 14.25 (95\% confidence interval, 4.70 to 43.23). High statistical between-study heterogeneity that could mainly be attributed to 2 studies was observed. The remaining 8 studies uniformly favored PCT use. CONCLUSIONS: In children with culture-proven UTI, a serum PCT value >0.5 ng/mL predicts reasonably well the presence of RPI, as evidenced by DMSA scintigraphy. PCT may aid in the identification of children with UTI, necessitating more intense evaluation and management.}, author = {Mantadakis, Elpis and Plessa, Eleni and Vouloumanou, Evridiki K. and Karageorgopoulos, Drosos E. and Chatzimichael, Athanasios and Falagas, Mathew E.}, citeulike-article-id = {6014161}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jpeds.2009.06.037}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19850301}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19850301}, day = {20}, doi = {10.1016/j.jpeds.2009.06.037}, issn = {1097-6833}, journal = {The Journal of pediatrics}, keywords = {procalcitonin, renal\_parenchymal\_involvement, uti}, month = {October}, posted-at = {2009-10-27 05:50:52}, priority = {2}, title = {Serum Procalcitonin for Prediction of Renal Parenchymal Involvement in Children with Urinary Tract Infections: A Meta-analysis of Prospective Clinical Studies.}, url = {http://dx.doi.org/10.1016/j.jpeds.2009.06.037}, year = {2009} }

TY - JOUR ID - citeulike:6014161 L3 - citeulike-article-id:6014161 N2 - OBJECTIVE: To determine by meta-analysis whether serum procalcitonin (PCT) is a useful marker of acute renal parenchymal involvement (RPI) in children with culture-proven urinary tract infection (UTI), as diagnosed by acute-phase DMSA (Tc-99m dimercaptosuccinic acid) renal scintigraphy. STUDY DESIGN: We searched PubMed and the Cochrane Central Register of Controlled Trials for prospective studies involving children with culture-proven UTIs. Additional eligibility criteria were measurement of serum PCT at presentation and performance of DMSA scintigraphy within 14 days. RESULTS: Overall, 10 studies eligible for inclusion, involving a total of 627 children, were identified. Half of these studies evaluated children with a first episode of UTI; 8 involved children with febrile UTIs. Using a cutoff value of 0.5 to 0.6 ng/mL, the pooled diagnostic odds ratio of serum PCT for UTI with RPI was 14.25 (95% confidence interval, 4.70 to 43.23). High statistical between-study heterogeneity that could mainly be attributed to 2 studies was observed. The remaining 8 studies uniformly favored PCT use. CONCLUSIONS: In children with culture-proven UTI, a serum PCT value >0.5 ng/mL predicts reasonably well the presence of RPI, as evidenced by DMSA scintigraphy. PCT may aid in the identification of children with UTI, necessitating more intense evaluation and management. JF - The Journal of pediatrics SN - 1097-6833 TI - Serum Procalcitonin for Prediction of Renal Parenchymal Involvement in Children with Urinary Tract Infections: A Meta-analysis of Prospective Clinical Studies. KW - procalcitonin KW - renal_parenchymal_involvement KW - uti AU - Mantadakis, Elpis AU - Plessa, Eleni AU - Vouloumanou, Evridiki AU - Karageorgopoulos, Drosos AU - Chatzimichael, Athanasios AU - Falagas, Mathew PY - 2009/10/20/ UR - http://dx.doi.org/10.1016/j.jpeds.2009.06.037 ER -