Increased Auditory Startle Reflex in Children with Functional Abdominal Pain. Export

@article{citeulike:6014163, abstract = {OBJECTIVE: To test the hypothesis that children with abdominal pain-related functional gastrointestinal disorders have a general hypersensitivity for sensory stimuli. STUDY DESIGN: Auditory startle reflexes were assessed in 20 children classified according to Rome III classifications of abdominal pain-related functional gastrointestinal disorders (13 irritable bowel syndrome [IBS], 7 functional abdominal pain syndrome; mean age, 12.4 years; 15 girls) and 23 control subjects (14 girls; mean age, 12.3 years) using a case-control design. The activity of 6 left-sided muscles and the sympathetic skin response were obtained by an electromyogram. We presented sudden loud noises to the subjects through headphones. RESULTS: Both the combined response of 6 muscles and the blink response proved to be significantly increased in patients with abdominal pain compared with control subjects. A significant increase of the sympathetic skin response was not found. Comorbid anxiety disorders (8 patients with abdominal pain) or Rome III subclassification did not significantly affect these results. CONCLUSIONS: This study demonstrates an objective hyperresponsivity to nongastrointestinal stimuli. Children with abdominal pain-related functional gastrointestinal disorders may have a generalized hypersensitivity of the central nervous system.}, author = {Bakker, Mirte J. and Boer, Frits and Benninga, Marc A. and Koelman, Johannes H. and Tijssen, Marina A.}, citeulike-article-id = {6014163}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jpeds.2009.08.045}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19846112}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19846112}, day = {19}, doi = {10.1016/j.jpeds.2009.08.045}, issn = {1097-6833}, journal = {The Journal of pediatrics}, keywords = {auditory\_startle\_reflex, functional\_abdominal\_pain}, month = {October}, posted-at = {2009-10-27 05:51:35}, priority = {2}, title = {Increased Auditory Startle Reflex in Children with Functional Abdominal Pain.}, url = {http://dx.doi.org/10.1016/j.jpeds.2009.08.045}, year = {2009} }

TY - JOUR ID - citeulike:6014163 L3 - citeulike-article-id:6014163 N2 - OBJECTIVE: To test the hypothesis that children with abdominal pain-related functional gastrointestinal disorders have a general hypersensitivity for sensory stimuli. STUDY DESIGN: Auditory startle reflexes were assessed in 20 children classified according to Rome III classifications of abdominal pain-related functional gastrointestinal disorders (13 irritable bowel syndrome [IBS], 7 functional abdominal pain syndrome; mean age, 12.4 years; 15 girls) and 23 control subjects (14 girls; mean age, 12.3 years) using a case-control design. The activity of 6 left-sided muscles and the sympathetic skin response were obtained by an electromyogram. We presented sudden loud noises to the subjects through headphones. RESULTS: Both the combined response of 6 muscles and the blink response proved to be significantly increased in patients with abdominal pain compared with control subjects. A significant increase of the sympathetic skin response was not found. Comorbid anxiety disorders (8 patients with abdominal pain) or Rome III subclassification did not significantly affect these results. CONCLUSIONS: This study demonstrates an objective hyperresponsivity to nongastrointestinal stimuli. Children with abdominal pain-related functional gastrointestinal disorders may have a generalized hypersensitivity of the central nervous system. JF - The Journal of pediatrics SN - 1097-6833 TI - Increased Auditory Startle Reflex in Children with Functional Abdominal Pain. KW - auditory_startle_reflex KW - functional_abdominal_pain AU - Bakker, Mirte AU - Boer, Frits AU - Benninga, Marc AU - Koelman, Johannes AU - Tijssen, Marina PY - 2009/10/19/ UR - http://dx.doi.org/10.1016/j.jpeds.2009.08.045 ER -