Favorable Outcome of Juvenile Dermatomyositis Treated without Systemic Corticosteroids. Export

@article{citeulike:6014164, abstract = {OBJECTIVE: To describe the course of patients with juvenile dermatomyositis (JDM) treated effectively without systemic corticosteroids. STUDY DESIGN: A retrospective study of 38 patients with JDM treated at a tertiary care children's hospital identified 8 patients who had never received corticosteroids. Disease presentation and course, pharmacologic, and ancillary treatments were recorded. RESULTS: Patients in the no corticosteroid group were followed for a median of 2.8 years (range, 2.1 to 9.5 years). Treatment was primarily with intravenous immunoglobulin (IVIG) (75\%) and methotrexate (50\%), with favorable response in all. No serious treatment complications were observed; headaches were reported by 3 patients receiving IVIG. Two patients had a myositis flare after discontinuing all medications for more than 1 year; complete resolution of symptoms was observed after either 1 or 2 further doses of IVIG. Two patients had calcinosis (at 1 and 9 years of disease); however, no patient had joint contractures, muscle atrophy, lipodystrophy, or functional limitations. CONCLUSIONS: Systemic corticosteroids can be avoided in a select group of patients with JDM. Alternative agents such as methotrexate and IVIG may be prescribed to effectively treat JDM and prevent complications.}, author = {Levy, Deborah M. and Bingham, C. April and Kahn, Philip J. and Eichenfield, Andrew H. and Imundo, Lisa F.}, citeulike-article-id = {6014164}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jpeds.2009.09.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19846111}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19846111}, day = {19}, doi = {10.1016/j.jpeds.2009.09.008}, issn = {1097-6833}, journal = {The Journal of pediatrics}, keywords = {juvenile\_dermatomyositis}, month = {October}, posted-at = {2009-10-27 05:51:54}, priority = {2}, title = {Favorable Outcome of Juvenile Dermatomyositis Treated without Systemic Corticosteroids.}, url = {http://dx.doi.org/10.1016/j.jpeds.2009.09.008}, year = {2009} }

TY - JOUR ID - citeulike:6014164 L3 - citeulike-article-id:6014164 N2 - OBJECTIVE: To describe the course of patients with juvenile dermatomyositis (JDM) treated effectively without systemic corticosteroids. STUDY DESIGN: A retrospective study of 38 patients with JDM treated at a tertiary care children's hospital identified 8 patients who had never received corticosteroids. Disease presentation and course, pharmacologic, and ancillary treatments were recorded. RESULTS: Patients in the no corticosteroid group were followed for a median of 2.8 years (range, 2.1 to 9.5 years). Treatment was primarily with intravenous immunoglobulin (IVIG) (75%) and methotrexate (50%), with favorable response in all. No serious treatment complications were observed; headaches were reported by 3 patients receiving IVIG. Two patients had a myositis flare after discontinuing all medications for more than 1 year; complete resolution of symptoms was observed after either 1 or 2 further doses of IVIG. Two patients had calcinosis (at 1 and 9 years of disease); however, no patient had joint contractures, muscle atrophy, lipodystrophy, or functional limitations. CONCLUSIONS: Systemic corticosteroids can be avoided in a select group of patients with JDM. Alternative agents such as methotrexate and IVIG may be prescribed to effectively treat JDM and prevent complications. JF - The Journal of pediatrics SN - 1097-6833 TI - Favorable Outcome of Juvenile Dermatomyositis Treated without Systemic Corticosteroids. KW - juvenile_dermatomyositis AU - Levy, Deborah AU - Bingham, April AU - Kahn, Philip AU - Eichenfield, Andrew AU - Imundo, Lisa PY - 2009/10/19/ UR - http://dx.doi.org/10.1016/j.jpeds.2009.09.008 ER -