Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. Export

@article{citeulike:1525486, abstract = {The capacity of splenic CD11c+ dendritic cell (DC) populations to present antigen (Ag) to T cells differs during malarial infection with Plasmodium chabaudi in mice. Both CD11c+ CD8+ and CD8- DCs presented malarial peptides on their surface during infection. However, although both DC subsets expressing malaria peptides could induce interferon-gamma production by CD4 T cells, only CD8- DCs isolated at the acute phase of infection stimulated Ag-specific T cell proliferation and interleukin (IL)-4 and -10 production from MSP1-specific T cell receptor for Ag transgenic T cells coincidental with our reported Th1 to Th2 switch at this stage in response to the pathogen. The timing of these distinct DC responses coincided with increased levels of apoptosis in the CD8+ population and an increase in the numbers of CD8- DCs in the spleen. Our data suggest that the switch in CD4 T cell responses observed in P. chabaudi-infected mice may be the result of the presentation by different DC populations modified by the malaria infection.}, address = {Division of Parasitology and 2Division of Immunoregulation, National Institute for Medical Research, London NW7 1AA, United Kingdom.}, author = {Sponaas, A. M. and Cadman, E. T. and Voisine, C. and Harrison, V. and Boonstra, A. and O'Garra, A. and Langhorne, J.}, citeulike-article-id = {1525486}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20052450}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16754719}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16754719}, day = {12}, doi = {10.1084/jem.20052450}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {dc}, month = {June}, number = {6}, pages = {1427--1433}, posted-at = {2007-07-31 17:40:49}, priority = {2}, title = {Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells.}, url = {http://dx.doi.org/10.1084/jem.20052450}, volume = {203}, year = {2006} }

TY - JOUR ID - citeulike:1525486 L3 - citeulike-article-id:1525486 N2 - The capacity of splenic CD11c+ dendritic cell (DC) populations to present antigen (Ag) to T cells differs during malarial infection with Plasmodium chabaudi in mice. Both CD11c+ CD8+ and CD8- DCs presented malarial peptides on their surface during infection. However, although both DC subsets expressing malaria peptides could induce interferon-gamma production by CD4 T cells, only CD8- DCs isolated at the acute phase of infection stimulated Ag-specific T cell proliferation and interleukin (IL)-4 and -10 production from MSP1-specific T cell receptor for Ag transgenic T cells coincidental with our reported Th1 to Th2 switch at this stage in response to the pathogen. The timing of these distinct DC responses coincided with increased levels of apoptosis in the CD8+ population and an increase in the numbers of CD8- DCs in the spleen. Our data suggest that the switch in CD4 T cell responses observed in P. chabaudi-infected mice may be the result of the presentation by different DC populations modified by the malaria infection. IS - 6 JF - J Exp Med SN - 0022-1007 AD - Division of Parasitology and 2Division of Immunoregulation, National Institute for Medical Research, London NW7 1AA, United Kingdom. EP - 1433 TI - Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. VL - 203 SP - 1427 KW - dc AU - Sponaas, AM AU - Cadman, ET AU - Voisine, C AU - Harrison, V AU - Boonstra, A AU - O'Garra, A AU - Langhorne, J PY - 2006/06/12/ UR - http://dx.doi.org/10.1084/jem.20052450 ER -