Mitochondrial DNA phylogeny in Eastern and Western Slavs. Export

@article{citeulike:2836798, abstract = {To resolve the phylogeny of certain mitochondrial DNA (mtDNA) haplogroups in Eastern Europe and estimate their evolutionary age, a total of 73 samples representing mitochondrial haplogroups U4, HV*, and R1 were selected for complete mitochondrial genome sequencing from a collection of about 2000 control-region sequences sampled in Eastern (Russians, Belorussians, Ukrainians) and Western (Poles, Czechs and Slovaks) Slavs. On the basis of whole-genome resolution, we fully characterized a number of haplogroups (HV3, HV4, U4a1, U4a2, U4a3, U4b, U4c, U4d, and R1a) that were previously described only partially. Our findings demonstrate that haplogroups HV3, HV4, and U4a1 could be traced back to the pre-Neolithic times ( approximately 12,000-19,000 YBP) in Eastern Europe. In addition, an ancient connection between the Caucasus/Europe and India has been revealed by analysis of haplogroup R1 diversity, with a split between the Indian and Caucasus/European R1a lineages occurring about 16,500 years ago. Meanwhile, some mtDNA subgroups detected in Slavs (such as U4a2a, U4a2*, HV3a, R1a1) are definitely younger being dated between 6,400-8,200 YBP. However, robust age estimations appear to be problematic due to the high ratios of non-synonymous to synonymous substitutions found in young mtDNA subclusters.}, address = {Institute of Biological Problems of the North, Far-East Branch of the Russian Academy of Sciences, Magadan, Russia.}, author = {Malyarchuk, B and Grzybowski, T and Derenko, M and Perkova, M and Vanecek, T and Lazur, J and Gomolcak, P and Tsybovsky, I}, citeulike-article-id = {2836798}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18477584}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18477584}, day = {13}, issn = {1537-1719}, journal = {Molecular biology and evolution}, keywords = {czech, hv, mt, poland, polish, russia, russian, slavic, slavs, slovak, slovakia, ukraine, ukrainian}, month = {May}, posted-at = {2008-05-27 09:36:58}, priority = {2}, title = {Mitochondrial DNA phylogeny in Eastern and Western Slavs.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18477584}, year = {2008} }

TY - JOUR ID - citeulike:2836798 L3 - citeulike-article-id:2836798 N2 - To resolve the phylogeny of certain mitochondrial DNA (mtDNA) haplogroups in Eastern Europe and estimate their evolutionary age, a total of 73 samples representing mitochondrial haplogroups U4, HV*, and R1 were selected for complete mitochondrial genome sequencing from a collection of about 2000 control-region sequences sampled in Eastern (Russians, Belorussians, Ukrainians) and Western (Poles, Czechs and Slovaks) Slavs. On the basis of whole-genome resolution, we fully characterized a number of haplogroups (HV3, HV4, U4a1, U4a2, U4a3, U4b, U4c, U4d, and R1a) that were previously described only partially. Our findings demonstrate that haplogroups HV3, HV4, and U4a1 could be traced back to the pre-Neolithic times ( approximately 12,000-19,000 YBP) in Eastern Europe. In addition, an ancient connection between the Caucasus/Europe and India has been revealed by analysis of haplogroup R1 diversity, with a split between the Indian and Caucasus/European R1a lineages occurring about 16,500 years ago. Meanwhile, some mtDNA subgroups detected in Slavs (such as U4a2a, U4a2*, HV3a, R1a1) are definitely younger being dated between 6,400-8,200 YBP. However, robust age estimations appear to be problematic due to the high ratios of non-synonymous to synonymous substitutions found in young mtDNA subclusters. JF - Molecular biology and evolution SN - 1537-1719 AD - Institute of Biological Problems of the North, Far-East Branch of the Russian Academy of Sciences, Magadan, Russia. TI - Mitochondrial DNA phylogeny in Eastern and Western Slavs. KW - czech KW - hv KW - mt KW - poland KW - polish KW - russia KW - russian KW - slavic KW - slavs KW - slovak KW - slovakia KW - ukraine KW - ukrainian AU - Malyarchuk, B AU - Grzybowski, T AU - Derenko, M AU - Perkova, M AU - Vanecek, T AU - Lazur, J AU - Gomolcak, P AU - Tsybovsky, I PY - 2008/05/13/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18477584 ER -