Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Export

@article{citeulike:556524, abstract = {In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.}, address = {Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no}, author = {Wisl{\o}ff, U. and Najjar, S. M. and Ellingsen, O. and Haram, P. M. and Swoap, S. and Al-Share, Q. and Fernstr\"{o}m, M. and Rezaei, K. and Lee, S. J. and Koch, L. G. and Britton, S. L.}, citeulike-article-id = {556524}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1108177}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/307/5708/418}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15662013}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15662013}, day = {21}, doi = {10.1126/science.1108177}, issn = {1095-9203}, journal = {Science}, keywords = {3397g, aerobic\_capacity, cardivascular, irs, mt}, month = {January}, number = {5708}, pages = {418--420}, posted-at = {2006-03-18 23:40:29}, priority = {5}, title = {Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.}, url = {http://dx.doi.org/10.1126/science.1108177}, volume = {307}, year = {2005} }

TY - JOUR ID - citeulike:556524 L3 - citeulike-article-id:556524 N2 - In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease. IS - 5708 JF - Science SN - 1095-9203 AD - Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no EP - 420 TI - Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. VL - 307 SP - 418 KW - 3397g KW - aerobic_capacity KW - cardivascular KW - irs KW - mt AU - Wisløff, U AU - Najjar, SM AU - Ellingsen, O AU - Haram, PM AU - Swoap, S AU - Al-Share, Q AU - Fernström, M AU - Rezaei, K AU - Lee, SJ AU - Koch, LG AU - Britton, SL PY - 2005/01/21/ UR - http://dx.doi.org/10.1126/science.1108177 ER -