European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing Among Diverse European Ethnic Groups. Export

@article{citeulike:5978695, abstract = {The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4000 subjects genotyped for 300 thousand SNPs we provide further insight into relationships among European population groups and identify sets of SNP ancestry informative markers (AIMs) for application in genetic studies. In general, the graphical description of these principal components analyses (PCA) of diverse European subjects showed a strong correspondence to the geographical relationships of specific countries or regions of origin. Clearer separation of different ethnic and regional populations was observed when northern and southern European groups were considered separately and the PCA results were influenced by the inclusion or exclusion of different self-identified population groups including Ashkenazi Jewish, Sardinian and Orcadian ethnic groups. SNP AIM sets were identified that could distinguish the regional and ethnic population groups. Moreover, the studies demonstrated that most allele frequency differences between different European groups could be effectively controlled in analyses using these AIM sets. The European substructure AIMs should be widely applicable to ongoing studies to confirm and delineate specific disease susceptibility candidate regions without the necessity to perform additional genome-wide SNP studies in additional subject sets.}, author = {Tian, Chao and Kosoy, Roman and Nassir, Rami and Lee, Annette and Villoslada, Pablo and Klareskog, Lars and Hammarstr\"{o}m, Lennart and Garchon, Henri-Jean J. and Pulver, Ann E. and Ransom, Michael and Gregersen, Peter K. and Seldin, Michael F.}, citeulike-article-id = {5978695}, citeulike-linkout-0 = {http://dx.doi.org/10.2119/molmed.2009.00094}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19707526}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19707526}, day = {24}, doi = {10.2119/molmed.2009.00094}, issn = {1528-3658}, journal = {Molecular medicine (Cambridge, Mass.)}, keywords = {aims, ancestry\_informative\_markers, ashkenazi, autosomal, bga, european, hgdp-ceph, pca, population\_substructure, principal\_components\_analysis}, month = {August}, posted-at = {2009-10-21 06:49:35}, priority = {5}, title = {European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing Among Diverse European Ethnic Groups.}, url = {http://dx.doi.org/10.2119/molmed.2009.00094}, year = {2009} }

TY - JOUR ID - citeulike:5978695 L3 - citeulike-article-id:5978695 N2 - The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4000 subjects genotyped for 300 thousand SNPs we provide further insight into relationships among European population groups and identify sets of SNP ancestry informative markers (AIMs) for application in genetic studies. In general, the graphical description of these principal components analyses (PCA) of diverse European subjects showed a strong correspondence to the geographical relationships of specific countries or regions of origin. Clearer separation of different ethnic and regional populations was observed when northern and southern European groups were considered separately and the PCA results were influenced by the inclusion or exclusion of different self-identified population groups including Ashkenazi Jewish, Sardinian and Orcadian ethnic groups. SNP AIM sets were identified that could distinguish the regional and ethnic population groups. Moreover, the studies demonstrated that most allele frequency differences between different European groups could be effectively controlled in analyses using these AIM sets. The European substructure AIMs should be widely applicable to ongoing studies to confirm and delineate specific disease susceptibility candidate regions without the necessity to perform additional genome-wide SNP studies in additional subject sets. JF - Molecular medicine (Cambridge, Mass.) SN - 1528-3658 TI - European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing Among Diverse European Ethnic Groups. KW - aims KW - ancestry_informative_markers KW - ashkenazi KW - autosomal KW - bga KW - european KW - hgdp-ceph KW - pca KW - population_substructure KW - principal_components_analysis AU - Tian, Chao AU - Kosoy, Roman AU - Nassir, Rami AU - Lee, Annette AU - Villoslada, Pablo AU - Klareskog, Lars AU - Hammarström, Lennart AU - Garchon, Henri-Jean AU - Pulver, Ann AU - Ransom, Michael AU - Gregersen, Peter AU - Seldin, Michael PY - 2009/08/24/ UR - http://dx.doi.org/10.2119/molmed.2009.00094 ER -