Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor Export

@article{citeulike:6052825, abstract = {To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 selected tribal populations of India. On the basis of complete mtDNA sequencing, we identified 12 new haplogroups - M53 to M64; redefined/ascertained and characterized haplogroups M2, M3, M4, M5, M6, M8\^{a}€²C\^{a}€²Z, M9, M10, M11, M12-G, D, M18, M30, M33, M35, M37, M38, M39, M40, M41, M43, M45 and M49, which were previously described by control and/or coding-region polymorphisms. Our results indicate that the mtDNA lineages reported in the present study (except East Asian lineages M8\^{a}€²C\^{a}€²Z, M9, M10, M11, M12-G, D ) are restricted to Indian region.The deep rooted lineages of macrohaplogroup \^{a}€˜M\^{a}€™ suggest in-situ origin of these haplogroups in India. Most of these deep rooting lineages are represented by multiple ethnic/linguist groups of India. Hierarchical analysis of molecular variation (AMOVA) shows substantial subdivisions among the tribes of India (F ST = 0.16164). The current Indian mtDNA gene pool was shaped by the initial settlers and was galvanized by minor events of gene flow from the east and west to the restricted zones. Northeast Indian mtDNA pool harbors region specific lineages, other Indian lineages and East Asian lineages. We also suggest the establishment of an East Asian gene in North East India through admixture rather than replacement.}, author = {Chandrasekar, Adimoolam and Kumar, Satish and Sreenath, Jwalapuram and Sarkar, Bishwa N. and Urade, Bhaskar P. and Mallick, Sujit and Bandopadhyay, Syam S. and Barua, Pinuma and Barik, Subihra S. and Basu, Debasish and Kiran, Uttaravalli and Gangopadhyay, Prodyot and Sahani, Ramesh and Prasad, Bhagavatula V. and Gangopadhyay, Shampa and Lakshmi, Gandikota R. and Ravuri, Rajasekhara R. and Padmaja, Koneru and Venugopal, Pulamaghatta N. and Sharma, Madhu B. and Rao, Vadlamudi R.}, citeulike-article-id = {6052825}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0007447}, day = {13}, doi = {10.1371/journal.pone.0007447}, journal = {PLoS ONE}, keywords = {d, india, m, m10, m11, m12-g, m18, m2, m3, m30, m33, m33c, m35, m37, m38, m39, m4, m40, m41, m43, m45, m49, m5, m6, m8cz, m9, mtdna}, month = {October}, number = {10}, pages = {e7447+}, posted-at = {2009-11-01 03:22:52}, priority = {5}, publisher = {Public Library of Science}, title = {Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor}, url = {http://dx.doi.org/10.1371/journal.pone.0007447}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:6052825 L3 - citeulike-article-id:6052825 N2 - To construct maternal phylogeny and prehistoric dispersals of modern human being in the Indian sub continent, a diverse subset of 641 complete mitochondrial DNA (mtDNA) genomes belonging to macrohaplogroup M was chosen from a total collection of 2,783 control-region sequences, sampled from 26 selected tribal populations of India. On the basis of complete mtDNA sequencing, we identified 12 new haplogroups - M53 to M64; redefined/ascertained and characterized haplogroups M2, M3, M4, M5, M6, M8′C′Z, M9, M10, M11, M12-G, D, M18, M30, M33, M35, M37, M38, M39, M40, M41, M43, M45 and M49, which were previously described by control and/or coding-region polymorphisms. Our results indicate that the mtDNA lineages reported in the present study (except East Asian lineages M8′C′Z, M9, M10, M11, M12-G, D ) are restricted to Indian region.The deep rooted lineages of macrohaplogroup ‘M’ suggest in-situ origin of these haplogroups in India. Most of these deep rooting lineages are represented by multiple ethnic/linguist groups of India. Hierarchical analysis of molecular variation (AMOVA) shows substantial subdivisions among the tribes of India (F ST = 0.16164). The current Indian mtDNA gene pool was shaped by the initial settlers and was galvanized by minor events of gene flow from the east and west to the restricted zones. Northeast Indian mtDNA pool harbors region specific lineages, other Indian lineages and East Asian lineages. We also suggest the establishment of an East Asian gene in North East India through admixture rather than replacement. IS - 10 JF - PLoS ONE TI - Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor PB - Public Library of Science VL - 4 SP - e7447 KW - d KW - india KW - m KW - m10 KW - m11 KW - m12-g KW - m18 KW - m2 KW - m3 KW - m30 KW - m33 KW - m33c KW - m35 KW - m37 KW - m38 KW - m39 KW - m4 KW - m40 KW - m41 KW - m43 KW - m45 KW - m49 KW - m5 KW - m6 KW - m8cz KW - m9 KW - mtdna AU - Chandrasekar, Adimoolam AU - Kumar, Satish AU - Sreenath, Jwalapuram AU - Sarkar, Bishwa AU - Urade, Bhaskar AU - Mallick, Sujit AU - Bandopadhyay, Syam AU - Barua, Pinuma AU - Barik, Subihra AU - Basu, Debasish AU - Kiran, Uttaravalli AU - Gangopadhyay, Prodyot AU - Sahani, Ramesh AU - Prasad, Bhagavatula AU - Gangopadhyay, Shampa AU - Lakshmi, Gandikota AU - Ravuri, Rajasekhara AU - Padmaja, Koneru AU - Venugopal, Pulamaghatta AU - Sharma, Madhu AU - Rao, Vadlamudi PY - 2009/10/13/ UR - http://dx.doi.org/10.1371/journal.pone.0007447 ER -