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A simple and efficient algorithm for gene selection using sparse logistic regression. Export

Bioinformatics, Vol. 19, No. 17. (22 November 2003), pp. 2246-2253.

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association marker microarray snp statistic

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MOTIVATION: This paper gives a new and efficient algorithm for the sparse logistic regression problem. The proposed algorithm is based on the Gauss-Seidel method and is asymptotically convergent. It is simple and extremely easy to implement; it neither uses any sophisticated mathematical programming software nor needs any matrix operations. It can be applied to a variety of real-world problems like identifying marker genes and building a classifier in the context of cancer diagnosis using microarray data. RESULTS: The gene selection method suggested in this paper is demonstrated on two real-world data sets and the results were found to be consistent with the literature. AVAILABILITY: The implementation of this algorithm is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml Supplementary Information: Supplementary material is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml


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