V2R gene families degenerated in primates, dog and cow, but expanded in opossum Export

@article{citeulike:1257671, abstract = {The V2R genes are expressed in the mammalian vomeronasal organ, and their products are involved in detecting pheromones. Here, we describe the evolution of the V2R gene family. We have found that the human, chimpanzee, macaque, cow and dog V2R gene families have completely degenerated. Each now contains 9-20 pseudogenes but no intact V2R genes. By contrast, opossum has \~{}90 intact V2R genes that mostly arose by duplication after opossum and rodent lineages diverged. One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined.}, author = {Young, Janet M. and Trask, Barbara J.}, citeulike-article-id = {1257671}, citeulike-linkout-0 = {http://www.sciencedirect.com/science/article/B6TCY-4NBR8G5-2/2/193c3851d33049f4f7e180a411f729f7}, journal = {Trends in Genetics}, keywords = {cow}, month = {May}, number = {5}, pages = {212--215}, posted-at = {2007-04-26 19:11:09}, priority = {2}, title = {V2R gene families degenerated in primates, dog and cow, but expanded in opossum}, url = {http://www.sciencedirect.com/science/article/B6TCY-4NBR8G5-2/2/193c3851d33049f4f7e180a411f729f7}, volume = {23}, year = {2007} }

TY - JOUR ID - citeulike:1257671 L3 - citeulike-article-id:1257671 N2 - The V2R genes are expressed in the mammalian vomeronasal organ, and their products are involved in detecting pheromones. Here, we describe the evolution of the V2R gene family. We have found that the human, chimpanzee, macaque, cow and dog V2R gene families have completely degenerated. Each now contains 9-20 pseudogenes but no intact V2R genes. By contrast, opossum has ~90 intact V2R genes that mostly arose by duplication after opossum and rodent lineages diverged. One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined. IS - 5 JF - Trends in Genetics EP - 215 TI - V2R gene families degenerated in primates, dog and cow, but expanded in opossum VL - 23 SP - 212 KW - cow AU - Young, Janet AU - Trask, Barbara PY - 2007/05// UR - http://www.sciencedirect.com/science/article/B6TCY-4NBR8G5-2/2/193c3851d33049f4f7e180a411f729f7 ER -