Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. Export

@article{citeulike:1272009, abstract = {Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current computational tools. Here we describe a new, efficient method for the analysis of dense genetic maps in pedigree data that provides extremely fast solutions to common problems such as allele-sharing analyses and haplotyping. We show that sparse binary trees represent patterns of gene flow in general pedigrees in a parsimonious manner, and derive a family of related algorithms for pedigree traversal. With these trees, exact likelihood calculations can be carried out efficiently for single markers or for multiple linked markers. Using an approximate multipoint calculation that ignores the unlikely possibility of a large number of recombinants further improves speed and provides accurate solutions in dense maps with thousands of markers. Our multipoint engine for rapid likelihood inference (Merlin) is a computer program that uses sparse inheritance trees for pedigree analysis; it performs rapid haplotyping, genotype error detection and affected pair linkage analyses and can handle more markers than other pedigree analysis packages.}, author = {Abecasis, Gon\c{c}alo R. and Cherny, Stacey S. and Cookson, William O. and Cardon, Lon R.}, citeulike-article-id = {1272009}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng786}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng786}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11731797}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11731797}, doi = {10.1038/ng786}, issn = {1061-4036}, journal = {Nature genetics}, keywords = {detection, linkage, snp, software}, month = {January}, number = {1}, pages = {97--101}, posted-at = {2007-05-13 09:47:32}, priority = {2}, title = {Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.}, url = {http://dx.doi.org/10.1038/ng786}, volume = {30}, year = {2002} }

TY - JOUR ID - citeulike:1272009 L3 - citeulike-article-id:1272009 N2 - Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current computational tools. Here we describe a new, efficient method for the analysis of dense genetic maps in pedigree data that provides extremely fast solutions to common problems such as allele-sharing analyses and haplotyping. We show that sparse binary trees represent patterns of gene flow in general pedigrees in a parsimonious manner, and derive a family of related algorithms for pedigree traversal. With these trees, exact likelihood calculations can be carried out efficiently for single markers or for multiple linked markers. Using an approximate multipoint calculation that ignores the unlikely possibility of a large number of recombinants further improves speed and provides accurate solutions in dense maps with thousands of markers. Our multipoint engine for rapid likelihood inference (Merlin) is a computer program that uses sparse inheritance trees for pedigree analysis; it performs rapid haplotyping, genotype error detection and affected pair linkage analyses and can handle more markers than other pedigree analysis packages. IS - 1 JF - Nature genetics SN - 1061-4036 EP - 101 TI - Merlin--rapid analysis of dense genetic maps using sparse gene flow trees. VL - 30 SP - 97 KW - detection KW - linkage KW - snp KW - software AU - Abecasis, Gonçalo AU - Cherny, Stacey AU - Cookson, William AU - Cardon, Lon PY - 2002/01// UR - http://dx.doi.org/10.1038/ng786 ER -