Association testing in a linked region using large pedigrees. Export

@article{citeulike:1292274, abstract = {This report describes computer implementation of a scheme for joint linkage and association analysis. The model implemented in the computer package Mendel estimates both recombination and linkage-disequilibrium parameters and conducts likelihood-ratio tests for (1) linkage alone, (2) linkage and association simultaneously, and (3) association in the presence of linkage. Application of the method to data from Finnish pedigrees with familial combined hyperlipidemia illustrates its potential for identification of associated SNP haplotypes in the presence of linkage. For the test results to be valid, good estimates of haplotype frequencies must be used in the analysis.}, address = {Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095-7088, USA. rcantor@mednet.ucla.edu}, author = {Cantor, R. M. and Chen, G. K. and Pajukanta, P. and Lange, K.}, citeulike-article-id = {1292274}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/428628}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15657872}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15657872}, doi = {10.1086/428628}, issn = {0002-9297}, journal = {Am J Hum Genet}, keywords = {association, linkage}, month = {March}, number = {3}, pages = {538--542}, posted-at = {2007-05-13 10:49:40}, priority = {2}, title = {Association testing in a linked region using large pedigrees.}, url = {http://dx.doi.org/10.1086/428628}, volume = {76}, year = {2005} }

TY - JOUR ID - citeulike:1292274 L3 - citeulike-article-id:1292274 N2 - This report describes computer implementation of a scheme for joint linkage and association analysis. The model implemented in the computer package Mendel estimates both recombination and linkage-disequilibrium parameters and conducts likelihood-ratio tests for (1) linkage alone, (2) linkage and association simultaneously, and (3) association in the presence of linkage. Application of the method to data from Finnish pedigrees with familial combined hyperlipidemia illustrates its potential for identification of associated SNP haplotypes in the presence of linkage. For the test results to be valid, good estimates of haplotype frequencies must be used in the analysis. IS - 3 JF - Am J Hum Genet SN - 0002-9297 AD - Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095-7088, USA. rcantor@mednet.ucla.edu EP - 542 TI - Association testing in a linked region using large pedigrees. VL - 76 SP - 538 KW - association KW - linkage AU - Cantor, RM AU - Chen, GK AU - Pajukanta, P AU - Lange, K PY - 2005/03// UR - http://dx.doi.org/10.1086/428628 ER -