Evaluating pedigree data. II. Identifying the cause of error in families with inconsistencies. Export

@article{citeulike:975321, abstract = {Pedigree data can be evaluated, and subsequently corrected, by analysis of the distribution of genetic markers, taking account of the possibility of mistyping . Using a model of pedigree error developed previously, we obtained the maximum likelihood estimates of error parameters in pedigree data from Tokelau. Posterior probabilities for the possible true relationships in each family are conditional on the putative relationships and the marker data are calculated using the parameter estimates. These probabilities are used as a basis for discriminating between pedigree error and genetic marker errors in families where inconsistencies have been observed. When applied to the Tokelau data and compared with the results of retyping inconsistent families, these statistical procedures are able to discriminate between pedigree and marker error, with approximately 90\% accuracy, for families with two or more offspring. The large proportion of inconsistencies inferred to be due to marker error (61\%) indicates the importance of discriminating between error sources when judging the reliability of putative relationship data. Application of our model of pedigree error has proved to be an efficient way of determining and subsequently correcting sources of error in extensive pedigree data collected in large surveys.}, author = {Lathrop, G. M. and Huntsman, J. W. and Hooper, A. B. and Ward, R. H.}, citeulike-article-id = {975321}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/6585347}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=6585347}, issn = {0001-5652}, journal = {Hum Hered}, keywords = {error, pedigree}, number = {6}, pages = {377--389}, posted-at = {2006-12-05 14:22:38}, priority = {2}, title = {Evaluating pedigree data. II. Identifying the cause of error in families with inconsistencies.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/6585347}, volume = {33}, year = {1983} }

TY - JOUR ID - citeulike:975321 L3 - citeulike-article-id:975321 N2 - Pedigree data can be evaluated, and subsequently corrected, by analysis of the distribution of genetic markers, taking account of the possibility of mistyping . Using a model of pedigree error developed previously, we obtained the maximum likelihood estimates of error parameters in pedigree data from Tokelau. Posterior probabilities for the possible true relationships in each family are conditional on the putative relationships and the marker data are calculated using the parameter estimates. These probabilities are used as a basis for discriminating between pedigree error and genetic marker errors in families where inconsistencies have been observed. When applied to the Tokelau data and compared with the results of retyping inconsistent families, these statistical procedures are able to discriminate between pedigree and marker error, with approximately 90% accuracy, for families with two or more offspring. The large proportion of inconsistencies inferred to be due to marker error (61%) indicates the importance of discriminating between error sources when judging the reliability of putative relationship data. Application of our model of pedigree error has proved to be an efficient way of determining and subsequently correcting sources of error in extensive pedigree data collected in large surveys. IS - 6 JF - Hum Hered SN - 0001-5652 EP - 389 TI - Evaluating pedigree data. II. Identifying the cause of error in families with inconsistencies. VL - 33 SP - 377 KW - error KW - pedigree AU - Lathrop, GM AU - Huntsman, JW AU - Hooper, AB AU - Ward, RH PY - 1983/// UR - http://view.ncbi.nlm.nih.gov/pubmed/6585347 ER -