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Duplicated Paralogous Genes Subject to Positive Selection in the Genome of Trypanosoma brucei Export

PLoS ONE, Vol. 3, No. 5. (28 May 2008), e2295.

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Whole genome studies have highlighted duplicated genes as important substrates for adaptive evolution. We have investigated adaptive evolution in this class of genes in the human parasite Trypanosoma brucei , as indicated by the ratio of non-synonymous (amino-acid changing) to synonymous (amino acid retaining) nucleotide substitution rates.


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