ORTHOLOGS, PARALOGS, AND EVOLUTIONARY GENOMICS1 Export

@article{Koonin2005, abstract = {Abstract Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A clear distinction between orthologs and paralogs is critical for the construction of a robust evolutionary classification of genes and reliable functional annotation of newly sequenced genomes. Genome comparisons show that orthologous relationships with genes from taxonomically distant species can be established for the majority of the genes from each sequenced genome. This review examines in depth the definitions and subtypes of orthologs and paralogs, outlines the principal methodological approaches employed for identification of orthology and paralogy, and considers evolutionary and functional implications of these concepts.}, address = {National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. koonin@ncbi.nlm.nih.gov}, author = {Koonin, E. V.}, citeulike-article-id = {556626}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.genet.39.073003.114725}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.genet.39.073003.114725}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16285863}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16285863}, doi = {10.1146/annurev.genet.39.073003.114725}, issn = {0066-4197}, journal = {Annual Review of Genetics}, keywords = {evolution, homology}, number = {1}, pages = {309--338}, posted-at = {2008-05-27 16:44:18}, priority = {2}, title = {ORTHOLOGS, PARALOGS, AND EVOLUTIONARY GENOMICS1}, url = {http://dx.doi.org/10.1146/annurev.genet.39.073003.114725}, volume = {39}, year = {2005} }

TY - JOUR ID - Koonin2005 L3 - citeulike-article-id:556626 N2 - Abstract Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A clear distinction between orthologs and paralogs is critical for the construction of a robust evolutionary classification of genes and reliable functional annotation of newly sequenced genomes. Genome comparisons show that orthologous relationships with genes from taxonomically distant species can be established for the majority of the genes from each sequenced genome. This review examines in depth the definitions and subtypes of orthologs and paralogs, outlines the principal methodological approaches employed for identification of orthology and paralogy, and considers evolutionary and functional implications of these concepts. IS - 1 JF - Annual Review of Genetics SN - 0066-4197 AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. koonin@ncbi.nlm.nih.gov EP - 338 TI - ORTHOLOGS, PARALOGS, AND EVOLUTIONARY GENOMICS1 VL - 39 SP - 309 KW - evolution KW - homology AU - Koonin, EV PY - 2005/// UR - http://dx.doi.org/10.1146/annurev.genet.39.073003.114725 ER -