On the Evolution of Codon Volatility Export

@article{citeulike:892924, abstract = {Volatility of a codon is defined as the probability that a random point mutation in the codon generates a nonsynonymous change. It has been proposed that higher-than-expected mean codon volatility of a gene indicates that positive selection for nonsynonymous changes has acted on the gene in the recent past. I show that strong frequency-dependent selection (minority advantage) in large populations can increase codon volatility slightly, whereas directional positive selection has no effect on volatility. Factors unrelated to positive selection, such as expression-related or GC-content-related codon usage bias, also affect volatility. These and other considerations suggest that codon volatility has only limited utility for detecting positive selection at the DNA sequence level. 10.1534/genetics.104.034884}, author = {Zhang, J.}, citeulike-article-id = {892924}, citeulike-linkout-0 = {http://dx.doi.org/10.1534/genetics.104.034884}, citeulike-linkout-1 = {http://www.genetics.org/cgi/content/abstract/169/1/495}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15466418}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15466418}, day = {1}, doi = {10.1534/genetics.104.034884}, journal = {Genetics}, key = {Zhang2005a}, keywords = {evolution, gene\_code, selection}, month = {January}, number = {1}, pages = {495--501}, posted-at = {2006-10-11 16:10:05}, priority = {3}, title = {On the Evolution of Codon Volatility}, url = {http://dx.doi.org/10.1534/genetics.104.034884}, volume = {169}, year = {2005} }

TY - JOUR ID - citeulike:892924 L3 - citeulike-article-id:892924 N2 - Volatility of a codon is defined as the probability that a random point mutation in the codon generates a nonsynonymous change. It has been proposed that higher-than-expected mean codon volatility of a gene indicates that positive selection for nonsynonymous changes has acted on the gene in the recent past. I show that strong frequency-dependent selection (minority advantage) in large populations can increase codon volatility slightly, whereas directional positive selection has no effect on volatility. Factors unrelated to positive selection, such as expression-related or GC-content-related codon usage bias, also affect volatility. These and other considerations suggest that codon volatility has only limited utility for detecting positive selection at the DNA sequence level. 10.1534/genetics.104.034884 IS - 1 JF - Genetics EP - 501 TI - On the Evolution of Codon Volatility VL - 169 SP - 495 KW - evolution KW - gene_code KW - selection AU - Zhang, J PY - 2005/01/01/ UR - http://dx.doi.org/10.1534/genetics.104.034884 ER -