Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Export

@article{citeulike:4364089, abstract = {The function of the bladder urothelium in modulating contractile responses of the underlying detrusor smooth muscle to muscarinic stimulation has been examined in the pig bladder. Saturation curves for [3H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. The presence of an intact urothelium on isolated bladder strips inhibited contractions induced by carbachol but not KCl. Contractions of a urothelium-denuded muscle strip were inhibited in the presence of a second bladder strip with an intact urothelium, but not if the second strip was denuded. The urothelium-induced inhibition of contractions was not prevented in the presence of L-NOARG, methylene blue, indomethacin, propranolol, suramin, TEA or apamin. The data suggest the presence of a diffusable, urothelium-derived inhibitory factor, which could not be identified but appears to be neither nitric oxide, a cyclo-oxygenase product, a catecholamine, adenosine, GABA nor an EDHF sensitive to apamin.}, author = {Hawthorn, M. H. and Chapple, C. R. and Cock, M. and Chess-Williams, R.}, citeulike-article-id = {4364089}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.bjp.0703068}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10711338}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10711338}, doi = {10.1038/sj.bjp.0703068}, issn = {0007-1188}, journal = {British journal of pharmacology}, keywords = {contractility, detrusor, in, muscle, urothelium, vitro}, month = {February}, number = {3}, pages = {416--419}, posted-at = {2009-04-19 00:55:11}, priority = {2}, title = {Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro.}, url = {http://dx.doi.org/10.1038/sj.bjp.0703068}, volume = {129}, year = {2000} }

TY - JOUR ID - citeulike:4364089 L3 - citeulike-article-id:4364089 N2 - The function of the bladder urothelium in modulating contractile responses of the underlying detrusor smooth muscle to muscarinic stimulation has been examined in the pig bladder. Saturation curves for [3H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. The presence of an intact urothelium on isolated bladder strips inhibited contractions induced by carbachol but not KCl. Contractions of a urothelium-denuded muscle strip were inhibited in the presence of a second bladder strip with an intact urothelium, but not if the second strip was denuded. The urothelium-induced inhibition of contractions was not prevented in the presence of L-NOARG, methylene blue, indomethacin, propranolol, suramin, TEA or apamin. The data suggest the presence of a diffusable, urothelium-derived inhibitory factor, which could not be identified but appears to be neither nitric oxide, a cyclo-oxygenase product, a catecholamine, adenosine, GABA nor an EDHF sensitive to apamin. IS - 3 JF - British journal of pharmacology SN - 0007-1188 EP - 419 TI - Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. VL - 129 SP - 416 KW - contractility KW - detrusor KW - in KW - muscle KW - urothelium KW - vitro AU - Hawthorn, MH AU - Chapple, CR AU - Cock, M AU - Chess-Williams, R PY - 2000/02// UR - http://dx.doi.org/10.1038/sj.bjp.0703068 ER -