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Single Silver Nanoparticles as Real-Time Optical Sensors with Zeptomole Sensitivity Export

Nano Letters, Vol. 3, No. 8. (1 August 2003), pp. 1057-1062.

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dark-field lithography lspr nsl sam silver single spectroscopy thiol

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This work utilizes dark-field optical microscopy to demonstrate the localized surface plasmon resonance lambdamax response of individual Ag nanoparticles to the formation of a monolayer of small-molecule adsorbates. The adsorption of fewer than 60 000 1-hexadecanethiol molecules on single Ag nanoparticles results in a localized surface plasmon resonance shift of 40.7 nm. Additionally, the kinetics of the single nanoparticle response was shown to be comparable to that of other real-time sensor technologies.


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