Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity Export

@article{lan_peg_05, abstract = {Clean silicon and gold-patterned silicon platforms were modified with methoxy-polyethylene glycol (M-PEG silane) via a self-assembly technique, which significantly improved their plasma protein resistance capability and cell patterning selectivity. Fibrinogen and IgG were used as model plasma proteins to study the efficacy of PEG layers in resisting protein adsorption. Selective cell patterning on the gold regions of a gold-patterned silicon substrate and tissue compatibility were studied with macrophage and fibroblast cells. The research also revealed how the presence of gold electrodes on a silicon substrate would influence the cell patterning selectivity. Our experimental results showed that the PEG-modified silicon surfaces had a high resistivity to protein and cell attachment and that the PEG-modified gold-patterned silicon surfaces nearly completely eliminated the protein adsorption and cell attachment on silicon. This study provides a new approach to developing biocompatible surfaces for silicon-based BioMEMS devices, particularly for biosensors where a metal-insulator format must be enforced.}, author = {Lan, S. and Veiseh, M. and Zhang, M.}, citeulike-article-id = {6075420}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bios.2004.06.025}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0956566304002507}, day = {15}, doi = {10.1016/j.bios.2004.06.025}, issn = {09565663}, journal = {Biosensors and Bioelectronics}, keywords = {adsorption, cell, fluorescence, gold, peg, protein, silicon, thiol, toluene}, month = {March}, number = {9}, pages = {1697--1708}, posted-at = {2009-11-05 17:03:08}, priority = {2}, title = {Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity}, url = {http://dx.doi.org/10.1016/j.bios.2004.06.025}, volume = {20}, year = {2005} }

TY - JOUR ID - lan_peg_05 L3 - citeulike-article-id:6075420 N2 - Clean silicon and gold-patterned silicon platforms were modified with methoxy-polyethylene glycol (M-PEG silane) via a self-assembly technique, which significantly improved their plasma protein resistance capability and cell patterning selectivity. Fibrinogen and IgG were used as model plasma proteins to study the efficacy of PEG layers in resisting protein adsorption. Selective cell patterning on the gold regions of a gold-patterned silicon substrate and tissue compatibility were studied with macrophage and fibroblast cells. The research also revealed how the presence of gold electrodes on a silicon substrate would influence the cell patterning selectivity. Our experimental results showed that the PEG-modified silicon surfaces had a high resistivity to protein and cell attachment and that the PEG-modified gold-patterned silicon surfaces nearly completely eliminated the protein adsorption and cell attachment on silicon. This study provides a new approach to developing biocompatible surfaces for silicon-based BioMEMS devices, particularly for biosensors where a metal-insulator format must be enforced. IS - 9 JF - Biosensors and Bioelectronics SN - 09565663 EP - 1708 TI - Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity VL - 20 SP - 1697 KW - adsorption KW - cell KW - fluorescence KW - gold KW - peg KW - protein KW - silicon KW - thiol KW - toluene AU - Lan, S AU - Veiseh, M AU - Zhang, M PY - 2005/03/15/ UR - http://dx.doi.org/10.1016/j.bios.2004.06.025 ER -