Ultrathin poly(ethylene glycol) films for silicon-based microdevices Export

@article{citeulike:6075422, abstract = {Development of poly(ethylene glycol) (PEG) films that are ultrathin, uniform, conformal and stable in vivo -like environments is extremely desirable for biocompatible silicon-based microdevices. To this end, we have characterized PEG thin films, created by chemical coupling, at different PEG concentrations for various immobilization times, using the techniques of X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), ellipsometry and contact angle measurement. A continuous increase in film thickness and contact angle was measured with increase in PEG concentration and immobilization time (30–120 min). The surface roughness had a minimum value for 1.0\% PEG (immobilization time=60 min). The biocompatibility of ultrathin PEG films was also tested using fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (BSA). Results indicated PEG-modified silicon surfaces to be more resistant to protein adsorption. The stability of ultrathin PEG films over time in dry and aqueous in vivo -like environments was also examined. While ultrathin PEG films were extremely stable in dry conditions, their stability was compromised in aqueous in vivo -like environments (PBS, 37 °C, pH 7.4, 5\% CO 2 ). Nevertheless, ultrathin PEG films retained their efficacy to control protein fouling for the period investigated.}, author = {Sharma, S.}, citeulike-article-id = {6075422}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0169-4332(02)01220-5}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0169-4332(02)01220-5}, day = {15}, doi = {10.1016/S0169-4332(02)01220-5}, issn = {01694332}, journal = {Applied Surface Science}, keywords = {nsh, read, tag}, month = {February}, number = {1-4}, pages = {218--229}, posted-at = {2009-11-05 17:03:42}, priority = {2}, title = {Ultrathin poly(ethylene glycol) films for silicon-based microdevices}, url = {http://dx.doi.org/10.1016/S0169-4332(02)01220-5}, volume = {206}, year = {2003} }

TY - JOUR ID - citeulike:6075422 L3 - citeulike-article-id:6075422 N2 - Development of poly(ethylene glycol) (PEG) films that are ultrathin, uniform, conformal and stable in vivo -like environments is extremely desirable for biocompatible silicon-based microdevices. To this end, we have characterized PEG thin films, created by chemical coupling, at different PEG concentrations for various immobilization times, using the techniques of X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), ellipsometry and contact angle measurement. A continuous increase in film thickness and contact angle was measured with increase in PEG concentration and immobilization time (30–120 min). The surface roughness had a minimum value for 1.0% PEG (immobilization time=60 min). The biocompatibility of ultrathin PEG films was also tested using fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (BSA). Results indicated PEG-modified silicon surfaces to be more resistant to protein adsorption. The stability of ultrathin PEG films over time in dry and aqueous in vivo -like environments was also examined. While ultrathin PEG films were extremely stable in dry conditions, their stability was compromised in aqueous in vivo -like environments (PBS, 37 °C, pH 7.4, 5% CO 2 ). Nevertheless, ultrathin PEG films retained their efficacy to control protein fouling for the period investigated. IS - 1-4 JF - Applied Surface Science SN - 01694332 EP - 229 TI - Ultrathin poly(ethylene glycol) films for silicon-based microdevices VL - 206 SP - 218 KW - nsh KW - read KW - tag AU - Sharma, S PY - 2003/02/15/ UR - http://dx.doi.org/10.1016/S0169-4332(02)01220-5 ER -