Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry Export

@inproceedings{citeulike:4126172, abstract = {A novel optical biosensor using a one-dimensional photonic crystal structure in a total-internal-reflection geometry (PCTIR) is presented and investigated for label-free biosensing applications. This simple configuration forms a micro Fabry- Perot resonator in the top layer which provides a narrow optical resonance to enable label-free, highly sensitive measurements for the presence of analytes on the sensing surface or the refractive index change of the surrounding medium in the enhanced evanescent field; and at the same time it employs an open sensing surface for real-time biomolecular binding detection. The high sensitivity of the sensor was experimentally demonstrated by bulk solvent refractive index changes, ultrathin molecular films adsorbed on the sensing surface, and real-time analytes binding, measuring both the spectral shift of the photonic crystal resonance and the change of the intensity ratio in a differential reflectance measurement. Detection limits of 7×10-8 RIU for bulk solvent refractive index, 6×10-5 nm for molecular layer thickness and 24 fg/mm2 for mass density were obtained, which represent a significant improvement relative to state-ofthe- art surface-plasmon-resonance (SPR)-based systems. The PC-TIR sensor is thus seen to be a promising technology platform for high sensitivity and accurate biomolecular detection.}, author = {Guo, Yunbo and Ye, Jing Y. and Divin, Charles and Thomas, Thommey P. and Myc, Andrzej and Tommaso and Jr and Norris, Theodore B.}, citeulike-article-id = {4126172}, citeulike-linkout-0 = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PSISDG00718800000171880B000001&idtype=cvips&gifs=yes}, citeulike-linkout-1 = {http://link.aip.org/link/?PSI/7188/71880B}, editor = {Cartwright, Alexander N. and Nicolau, Dan V.}, journal = {Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI}, keywords = {biological-sensor, index-of-refraction, interface, interference, photonic-crystal-sensor, sio2}, location = {San Jose, CA, USA}, number = {1}, posted-at = {2009-03-03 16:47:00}, priority = {2}, publisher = {SPIE}, title = {Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PSISDG00718800000171880B000001&idtype=cvips&gifs=yes}, volume = {7188}, year = {2009} }

TY - CONF ID - citeulike:4126172 L3 - citeulike-article-id:4126172 N2 - A novel optical biosensor using a one-dimensional photonic crystal structure in a total-internal-reflection geometry (PCTIR) is presented and investigated for label-free biosensing applications. This simple configuration forms a micro Fabry- Perot resonator in the top layer which provides a narrow optical resonance to enable label-free, highly sensitive measurements for the presence of analytes on the sensing surface or the refractive index change of the surrounding medium in the enhanced evanescent field; and at the same time it employs an open sensing surface for real-time biomolecular binding detection. The high sensitivity of the sensor was experimentally demonstrated by bulk solvent refractive index changes, ultrathin molecular films adsorbed on the sensing surface, and real-time analytes binding, measuring both the spectral shift of the photonic crystal resonance and the change of the intensity ratio in a differential reflectance measurement. Detection limits of 7×10-8 RIU for bulk solvent refractive index, 6×10-5 nm for molecular layer thickness and 24 fg/mm2 for mass density were obtained, which represent a significant improvement relative to state-ofthe- art surface-plasmon-resonance (SPR)-based systems. The PC-TIR sensor is thus seen to be a promising technology platform for high sensitivity and accurate biomolecular detection. CY - San Jose, CA, USA IS - 1 JF - Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI TI - Label-free biosensing using a photonic crystal structure in a total-internal-reflection geometry PB - SPIE VL - 7188 KW - biological-sensor KW - index-of-refraction KW - interface KW - interference KW - photonic-crystal-sensor KW - sio2 AU - Guo, Yunbo AU - Ye, Jing AU - Divin, Charles AU - Thomas, Thommey AU - Myc, Andrzej AU - Tommaso AU - Jr AU - Norris, Theodore A2 - Cartwright, Alexander A2 - Nicolau, Dan PY - 2009/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PSISDG00718800000171880B000001&idtype=cvips&gifs=yes ER -