A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa

by: Martin Schuster, Peter

International Journal of Medical Microbiology, Vol. 296, No. 2-3. (6 April 2006), pp. 73-81.

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Abstract

The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptibility of P. aeruginosa to diverse environments.

@article{citeulike:708221, abstract = {The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptibility of P. aeruginosa to diverse environments.}, author = {Schuster, Martin and Peter}, booktitle = {Quorum sensing in human pathogens}, citeulike-article-id = {708221}, doi = {10.1016/j.ijmm.2006.01.036}, journal = {International Journal of Medical Microbiology}, keywords = {pseudomonas, quorum-sensing}, month = {April}, number = {2-3}, pages = {73--81}, posted-at = {2007-11-25 16:24:31}, priority = {2}, title = {A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa}, url = {http://dx.doi.org/10.1016/j.ijmm.2006.01.036}, volume = {296}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:708221 L3 - citeulike-article-id:708221 TI - A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa T2 - Quorum sensing in human pathogens JF - International Journal of Medical Microbiology VL - 296 IS - 2-3 SP - 73 EP - 81 N2 - The opportunistic pathogen Pseudomonas aeruginosa possesses two N-acyl-homoserine lactone quorum-sensing systems that regulate large, overlapping sets of genes. Recent global transcriptome and proteome analyses provided a wealth of information about the identity of the regulated genes, N-acyl-homoserine lactone signal specificity, timing of induction, and environmental effects on gene expression. Quorum-sensing gene expression in P. aeruginosa is also embedded in a highly interconnected network of other regulatory systems with a high potential for integrating and responding to multiple environmental signals. Such epigenetic complexity may constitute the basis for the exceptional adaptibility of P. aeruginosa to diverse environments. KW - pseudomonas KW - quorum-sensing AU - Schuster, Martin AU - Peter PY - 2006/04/06/ UR - http://dx.doi.org/10.1016/j.ijmm.2006.01.036 ER -

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